5i2q - Revision history

OCA at 08:21, 23 August 2023

OCA — Wed, 23 Aug 2023 08:21:10 GMT

←Older revision		Revision as of 08:21, 23 August 2023
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	<StructureSection load='5i2q' size='340' side='right'caption='[[5i2q]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='5i2q' size='340' side='right'caption='[[5i2q]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i2q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5I2Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I2Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.935Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5i2l\|5i2l]], [[5i2o\|5i2o]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">EFHD2, SWS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2q OCA], [https://pdbe.org/5i2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i2q RCSB], [https://www.ebi.ac.uk/pdbsum/5i2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5i2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2q OCA], [~~http~~://pdbe.org/5i2q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5i2q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5i2q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/EFHD2_HUMAN EFHD2_HUMAN]] May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.	+	[https://www.uniprot.org/uniprot/EFHD2_HUMAN EFHD2_HUMAN] May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: An~~, J Y~~]]	+	[[Category: An JY]]
-	[[Category: Cheong, H]]	+	[[Category: Cheong H]]
-	[[Category: Eom~~, S H~~]]	+	[[Category: Eom SH]]
-	[[Category: Jun, C]]	+	[[Category: Jun C]]
-	[[Category: Kang~~, J Y~~]]	+	[[Category: Kang JY]]
-	[[Category: Kim~~, T G~~]]	+	[[Category: Kim TG]]
-	[[Category: Kwon~~, M S~~]]	+	[[Category: Kwon MS]]
-	[[Category: Lee~~, J G~~]]	+	[[Category: Lee JG]]
-	[[Category: Lee~~, S H~~]]	+	[[Category: Lee SH]]
-	[[Category: Lee, Y]]	+	[[Category: Lee Y]]
-	[[Category: Lim~~, J J~~]]	+	[[Category: Lim JJ]]
-	[[Category: Park~~, J S~~]]	+	[[Category: Park JS]]
-	[[Category: Park~~, K R~~]]	+	[[Category: Park KR]]
-	[[Category: Song~~, W K~~]]	+	[[Category: Song WK]]
-	[[Category: Youn~~, H S]]~~	+	[[Category: Youn HS]]
-	~~[[Category: Calcium binding protein]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 08:43, 27 May 2020

OCA — Wed, 27 May 2020 08:43:14 GMT

←Older revision		Revision as of 08:43, 27 May 2020
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	==Structure of EF-hand containing protein==		==Structure of EF-hand containing protein==
-	<StructureSection load='5i2q' size='340' side='right' caption='[[5i2q]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='5i2q' size='340' side='right'caption='[[5i2q]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i2q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5I2Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I2Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i2l\|5i2l]], [[5i2o\|5i2o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i2l\|5i2l]], [[5i2o\|5i2o]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5i2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2q OCA], [http://pdbe.org/5i2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2q RCSB], [http://www.ebi.ac.uk/pdbsum/5i2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2q ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EFHD2, SWS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2q OCA], [http://pdbe.org/5i2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2q RCSB], [http://www.ebi.ac.uk/pdbsum/5i2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: An, J Y]]		[[Category: An, J Y]]
	[[Category: Cheong, H]]		[[Category: Cheong, H]]

OCA at 16:17, 2 January 2017

OCA — Mon, 02 Jan 2017 16:17:30 GMT

←Older revision		Revision as of 16:17, 2 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5i2q is ~~ON HOLD until Paper~~ Publication	+	==Structure of EF-hand containing protein==
		+	<StructureSection load='5i2q' size='340' side='right' caption='[[5i2q]], [[Resolution\|resolution]] 1.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5i2q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I2Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i2l\|5i2l]], [[5i2o\|5i2o]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2q OCA], [http://pdbe.org/5i2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2q RCSB], [http://www.ebi.ac.uk/pdbsum/5i2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2q ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EFHD2_HUMAN EFHD2_HUMAN]] May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	EFhd2/Swiprosin-1 is a cytoskeletal Ca2+-binding protein implicated in Ca2+-dependent cell spreading and migration in epithelial cells. EFhd2 domain architecture includes an N-terminal disordered region, a PxxP motif, two EF-hands, a ligand mimic helix and a C-terminal coiled-coil domain. We reported previously that EFhd2 displays F-actin bundling activity in the presence of Ca2+ and this activity depends on the coiled-coil domain and direct interaction of the EFhd2 core region. However, the molecular mechanism for the regulation of F-actin binding and bundling by EFhd2 is unknown. Here, the Ca2+-bound crystal structure of the EFhd2 core region is presented and structures of mutants defective for Ca2+-binding are also described. These structures and biochemical analyses reveal that the F-actin bundling activity of EFhd2 depends on the structural rigidity of F-actin binding sites conferred by binding of the EF-hands to Ca2+. In the absence of Ca2+, the EFhd2 core region exhibits local conformational flexibility around the EF-hand domain and C-terminal linker, which retains F-actin binding activity but loses the ability to bundle F-actin. In addition, we establish that dimerisation of EFhd2 via the C-terminal coiled-coil domain, which is necessary for F-actin bundling, occurs through the parallel coiled-coil interaction.

-	~~Authors:~~ Park~~, K.R.~~, Kwon~~, M.S.~~, An~~, J.Y.~~, Lee~~, J.G.~~, Youn~~, H.S.~~, Lee, Y., Kang~~, J.Y.~~, Kim~~, T.G.~~, Lim~~, J.J.~~, Park~~, J.S.~~, Lee~~, S.H.~~, Song~~, W.K.~~, Cheong~~, H.~~, Jun~~, C.~~, Eom~~, S~~.H.	+	Structural implications of Ca2+-dependent actin-bundling function of human EFhd2/Swiprosin-1.,Park KR, Kwon MS, An JY, Lee JG, Youn HS, Lee Y, Kang JY, Kim TG, Lim JJ, Park JS, Lee SH, Song WK, Cheong HK, Jun CD, Eom SH Sci Rep. 2016 Dec 15;6:39095. doi: 10.1038/srep39095. PMID:27974828<ref>PMID:27974828</ref>

-	~~Description: Structure~~ of ~~EF-hand containing protein~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Jun~~, C]]	+	<div class="pdbe-citations 5i2q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: An, J Y]]
	[[Category: Cheong, H]]		[[Category: Cheong, H]]
-	[[Category: ~~Lee~~, S.H]]	+	[[Category: Eom, S H]]
-	[[Category: ~~Kim~~, ~~T.G~~]]	+	[[Category: Jun, C]]
-	[[Category: ~~Lee~~, J.G]]	+	[[Category: Kang, J Y]]
-	[[Category: ~~Lim~~, ~~J.J~~]]	+	[[Category: Kim, T G]]
-	[[Category: Kwon, M.S]]	+	[[Category: Kwon, M S]]
-	[[Category: ~~Eom, S.H]]~~	+	[[Category: Lee, J G]]
-	~~[[Category: An~~, J.Y]]	+	[[Category: Lee, S H]]
-	[[Category: ~~Park~~, J.S]]	+
-	~~[[Category: Park, K.R]]~~	+
-	~~[[Category: Youn,~~ H~~.S]]~~	+
-	~~[[Category: Kang, J.Y]]~~	+
-	~~[[Category: Song, W.K~~]]	+
	[[Category: Lee, Y]]		[[Category: Lee, Y]]
		+	[[Category: Lim, J J]]
		+	[[Category: Park, J S]]
		+	[[Category: Park, K R]]
		+	[[Category: Song, W K]]
		+	[[Category: Youn, H S]]
		+	[[Category: Calcium binding protein]]
		+	[[Category: Metal binding protein]]

OCA at 12:18, 1 June 2016

OCA — Wed, 01 Jun 2016 12:18:01 GMT

←Older revision		Revision as of 12:18, 1 June 2016
Line 3:		Line 3:
	The entry 5i2q is ON HOLD until Paper Publication		The entry 5i2q is ON HOLD until Paper Publication

-	Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G., Lim, J.J., Park, J.S., Lee, S.H., Song, W.K, Cheong, H., Jun, C., Eom, S.H.	+	Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G., Lim, J.J., Park, J.S., Lee, S.H., Song, W.K., Cheong, H., Jun, C., Eom, S.H.

	Description: Structure of EF-hand containing protein		Description: Structure of EF-hand containing protein
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Jun, C]]		[[Category: Jun, C]]
-	[[Category: ~~Song, W.K,~~ Cheong, H]]	+	[[Category: Cheong, H]]
	[[Category: Lee, S.H]]		[[Category: Lee, S.H]]
	[[Category: Kim, T.G]]		[[Category: Kim, T.G]]
Line 20:		Line 20:
	[[Category: Youn, H.S]]		[[Category: Youn, H.S]]
	[[Category: Kang, J.Y]]		[[Category: Kang, J.Y]]
		+	[[Category: Song, W.K]]
	[[Category: Lee, Y]]		[[Category: Lee, Y]]

OCA at 01:48, 10 March 2016

OCA — Thu, 10 Mar 2016 01:48:02 GMT

←Older revision		Revision as of 01:48, 10 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5i2q is ON HOLD	+	The entry 5i2q is ON HOLD until Paper Publication

	Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G., Lim, J.J., Park, J.S., Lee, S.H., Song, W.K, Cheong, H., Jun, C., Eom, S.H.		Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G., Lim, J.J., Park, J.S., Lee, S.H., Song, W.K, Cheong, H., Jun, C., Eom, S.H.

OCA at 16:40, 26 February 2016

OCA — Fri, 26 Feb 2016 16:40:38 GMT

←Older revision		Revision as of 16:40, 26 February 2016
Line 3:		Line 3:
	The entry 5i2q is ON HOLD		The entry 5i2q is ON HOLD

-	Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G, Lim, J.J., Park, J.S., Lee, S.H., Song, W.K, Cheong, H-., Jun, C-., Eom, S.H.	+	Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G., Lim, J.J., Park, J.S., Lee, S.H., Song, W.K, Cheong, H., Jun, C., Eom, S.H.

-	Description: EF-hand containing protein	+	Description: Structure of EF-hand containing protein
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Jun, C]]
		+	[[Category: Song, W.K, Cheong, H]]
	[[Category: Lee, S.H]]		[[Category: Lee, S.H]]
		+	[[Category: Kim, T.G]]
	[[Category: Lee, J.G]]		[[Category: Lee, J.G]]
		+	[[Category: Lim, J.J]]
	[[Category: Kwon, M.S]]		[[Category: Kwon, M.S]]
	[[Category: Eom, S.H]]		[[Category: Eom, S.H]]
	[[Category: An, J.Y]]		[[Category: An, J.Y]]
	[[Category: Park, J.S]]		[[Category: Park, J.S]]
-	[[Category: Kim, T.G, Lim, J.J]]
-	[[Category: Jun, C-]]
-	[[Category: Song, W.K, Cheong, H-]]
	[[Category: Park, K.R]]		[[Category: Park, K.R]]
	[[Category: Youn, H.S]]		[[Category: Youn, H.S]]
	[[Category: Kang, J.Y]]		[[Category: Kang, J.Y]]
	[[Category: Lee, Y]]		[[Category: Lee, Y]]

OCA: Protected "5i2q" [edit=sysop:move=sysop]

OCA — Sun, 21 Feb 2016 01:29:47 GMT

Protected "5i2q" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:29, 21 February 2016

OCA: New page: '''Unreleased structure''' The entry 5i2q is ON HOLD Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G, Lim, J.J., Park, J.S., Lee, S.H., S...

OCA — Sun, 21 Feb 2016 01:29:46 GMT

New page: '''Unreleased structure''' The entry 5i2q is ON HOLD Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G, Lim, J.J., Park, J.S., Lee, S.H., S...

New page

'''Unreleased structure'''

The entry 5i2q is ON HOLD

Authors: Park, K.R., Kwon, M.S., An, J.Y., Lee, J.G., Youn, H.S., Lee, Y., Kang, J.Y., Kim, T.G, Lim, J.J., Park, J.S., Lee, S.H., Song, W.K, Cheong, H-., Jun, C-., Eom, S.H.

Description: EF-hand containing protein
[[Category: Unreleased Structures]]
[[Category: Lee, S.H]]
[[Category: Lee, J.G]]
[[Category: Kwon, M.S]]
[[Category: Eom, S.H]]
[[Category: An, J.Y]]
[[Category: Park, J.S]]
[[Category: Kim, T.G, Lim, J.J]]
[[Category: Jun, C-]]
[[Category: Song, W.K, Cheong, H-]]
[[Category: Park, K.R]]
[[Category: Youn, H.S]]
[[Category: Kang, J.Y]]
[[Category: Lee, Y]]