5i66 - Revision history

OCA at 08:24, 23 August 2023

OCA — Wed, 23 Aug 2023 08:24:22 GMT

←Older revision		Revision as of 08:24, 23 August 2023
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	<StructureSection load='5i66' size='340' side='right'caption='[[5i66]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='5i66' size='340' side='right'caption='[[5i66]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i66]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I66 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5I66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I66 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5i6x\|5i6x]]~~, [[~~5i6z~~\|~~5i6z]], [[5i71\|5i71]], [[5i73\|5i73]], [[5i74\|5i74]], [[5i75\|5i75~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.624Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i66 OCA], [~~http~~://pdbe.org/5i66 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5i66 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5i66 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5i66 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i66 OCA], [https://pdbe.org/5i66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i66 RCSB], [https://www.ebi.ac.uk/pdbsum/5i66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i66 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Coleman~~, J A~~]]	+	[[Category: Coleman JA]]
-	[[Category: Gouaux, E]]	+	[[Category: Gouaux E]]
-	[[Category: Green~~, E M]]~~	+	[[Category: Green EM]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold~~]]	+

OCA at 16:16, 20 November 2019

OCA — Wed, 20 Nov 2019 16:16:59 GMT

←Older revision		Revision as of 16:16, 20 November 2019
Line 1:		Line 1:

	==X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter==		==X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter==
-	<StructureSection load='5i66' size='340' side='right' caption='[[5i66]], [[Resolution\|resolution]] 1.62Å' scene=''>	+	<StructureSection load='5i66' size='340' side='right'caption='[[5i66]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5i66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I66 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5i66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I66 FirstGlance]. <br>
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Coleman, J A]]		[[Category: Coleman, J A]]

OCA at 13:33, 16 November 2017

OCA — Thu, 16 Nov 2017 13:33:45 GMT

←Older revision		Revision as of 13:33, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='5i66' size='340' side='right' caption='[[5i66]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='5i66' size='340' side='right' caption='[[5i66]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i66]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I66 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i6x\|5i6x]], [[5i6z\|5i6z]], [[5i71\|5i71]], [[5i73\|5i73]], [[5i74\|5i74]], [[5i75\|5i75]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i6x\|5i6x]], [[5i6z\|5i6z]], [[5i71\|5i71]], [[5i73\|5i73]], [[5i74\|5i74]], [[5i75\|5i75]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i66 OCA], [http://pdbe.org/5i66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i66 RCSB], [http://www.ebi.ac.uk/pdbsum/5i66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i66 OCA], [http://pdbe.org/5i66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i66 RCSB], [http://www.ebi.ac.uk/pdbsum/5i66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i66 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5i66" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5i66" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Coleman, J A]]		[[Category: Coleman, J A]]
	[[Category: Gouaux, E]]		[[Category: Gouaux, E]]

OCA at 17:37, 10 May 2016

OCA — Tue, 10 May 2016 17:37:40 GMT

←Older revision		Revision as of 17:37, 10 May 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5i66 is ~~ON HOLD until Paper~~ Publication	+	==X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter==
		+	<StructureSection load='5i66' size='340' side='right' caption='[[5i66]], [[Resolution\|resolution]] 1.62Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5i66]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I66 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i6x\|5i6x]], [[5i6z\|5i6z]], [[5i71\|5i71]], [[5i73\|5i73]], [[5i74\|5i74]], [[5i75\|5i75]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i66 OCA], [http://pdbe.org/5i66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i66 RCSB], [http://www.ebi.ac.uk/pdbsum/5i66 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The serotonin transporter (SERT) terminates serotonergic signalling through the sodium- and chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target for antidepressant and psychostimulant drugs, which block reuptake and prolong neurotransmitter signalling. Here we report X-ray crystallographic structures of human SERT at 3.15 A resolution bound to the antidepressants (S)-citalopram or paroxetine. Antidepressants lock SERT in an outward-open conformation by lodging in the central binding site, located between transmembrane helices 1, 3, 6, 8 and 10, directly blocking serotonin binding. We further identify the location of an allosteric site in the complex as residing at the periphery of the extracellular vestibule, interposed between extracellular loops 4 and 6 and transmembrane helices 1, 6, 10 and 11. Occupancy of the allosteric site sterically hinders ligand unbinding from the central site, providing an explanation for the action of (S)-citalopram as an allosteric ligand. These structures define the mechanism of antidepressant action in SERT, and provide blueprints for future drug design.

-	~~Authors: Coleman, J.A~~., Green, E.M.~~, Gouaux, E~~.	+	X-ray structures and mechanism of the human serotonin transporter.,Coleman JA, Green EM, Gouaux E Nature. 2016 Apr 21;532(7599):334-9. doi: 10.1038/nature17629. Epub 2016 Apr 6. PMID:27049939<ref>PMID:27049939</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5i66" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Coleman, J A]]
	[[Category: Gouaux, E]]		[[Category: Gouaux, E]]
-	[[Category: Green, E.M]]	+	[[Category: Green, E M]]
-	[[Category: ~~Coleman, J.A~~]]	+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold]]

OCA at 13:25, 2 March 2016

OCA — Wed, 02 Mar 2016 13:25:49 GMT

←Older revision		Revision as of 13:25, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5i66 is ON HOLD	+	The entry 5i66 is ON HOLD until Paper Publication

	Authors: Coleman, J.A., Green, E.M., Gouaux, E.		Authors: Coleman, J.A., Green, E.M., Gouaux, E.

OCA: Protected "5i66" [edit=sysop:move=sysop]

OCA — Fri, 26 Feb 2016 16:50:37 GMT

Protected "5i66" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:50, 26 February 2016

OCA: New page: '''Unreleased structure''' The entry 5i66 is ON HOLD Authors: Coleman, J.A., Green, E.M., Gouaux, E. Description: Category: Unreleased Structures Category: Gouaux, E [[Categor...

OCA — Fri, 26 Feb 2016 16:50:35 GMT

New page: '''Unreleased structure''' The entry 5i66 is ON HOLD Authors: Coleman, J.A., Green, E.M., Gouaux, E. Description: Category: Unreleased Structures Category: Gouaux, E [[Categor...

New page

'''Unreleased structure'''

The entry 5i66 is ON HOLD

Authors: Coleman, J.A., Green, E.M., Gouaux, E.

Description:
[[Category: Unreleased Structures]]
[[Category: Gouaux, E]]
[[Category: Green, E.M]]
[[Category: Coleman, J.A]]