5i6c - Revision history

OCA at 08:24, 23 August 2023

OCA — Wed, 23 Aug 2023 08:24:33 GMT

←Older revision		Revision as of 08:24, 23 August 2023
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	<StructureSection load='5i6c' size='340' side='right'caption='[[5i6c]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='5i6c' size='340' side='right'caption='[[5i6c]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i6c]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aspergillus_nidulans~~ Aspergillus nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I6C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5I6C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i6c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans_FGSC_A4 Aspergillus nidulans FGSC A4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I6C FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=LMT:DODECYL~~-~~BETA-D-MALTOSIDE'>LMT</scene>~~, ~~<scene name='pdbligand=XAN:XANTHINE'>XAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~uapA, AN6932 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=227321 Aspergillus nidulans])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5i6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i6c OCA], [~~http~~://pdbe.org/5i6c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5i6c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5i6c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5i6c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i6c OCA], [https://pdbe.org/5i6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i6c RCSB], [https://www.ebi.ac.uk/pdbsum/5i6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i6c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/UAPA_EMENI UAPA_EMENI]] Uric acid-xanthine transporter.<ref>PMID:15953615</ref> <ref>PMID:16096268</ref> <ref>PMID:20002879</ref>	+	[https://www.uniprot.org/uniprot/UAPA_EMENI UAPA_EMENI] Uric acid-xanthine transporter.<ref>PMID:15953615</ref> <ref>PMID:16096268</ref> <ref>PMID:20002879</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aspergillus nidulans]]	+	[[Category: Aspergillus nidulans FGSC A4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alguel, Y]]	+	[[Category: Alguel Y]]
-	[[Category: Amillis, S]]	+	[[Category: Amillis S]]
-	[[Category: Armstrong, A]]	+	[[Category: Armstrong A]]
-	[[Category: Byrne, B]]	+	[[Category: Byrne B]]
-	[[Category: Cameron~~, A D~~]]	+	[[Category: Cameron AD]]
-	[[Category: Capaldi, S]]	+	[[Category: Capaldi S]]
-	[[Category: Craven, G]]	+	[[Category: Craven G]]
-	[[Category: Diallinas, G]]	+	[[Category: Diallinas G]]
-	[[Category: Iwata, S]]	+	[[Category: Iwata S]]
-	[[Category: Lambrinidis, G]]	+	[[Category: Lambrinidis G]]
-	[[Category: Leung, J]]	+	[[Category: Leung J]]
-	[[Category: Mikros, E]]	+	[[Category: Mikros E]]
-	[[Category: Scull~~, N J]]~~	+	[[Category: Scull NJ]]
-	~~[[Category: Membrane protein eukaryotic uric acid/xanthine h+ symporter]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:06, 3 June 2020

OCA — Wed, 03 Jun 2020 07:06:19 GMT

←Older revision		Revision as of 07:06, 3 June 2020
Line 1:		Line 1:

	==The structure of the eukaryotic purine/H+ symporter, UapA, in complex with Xanthine==		==The structure of the eukaryotic purine/H+ symporter, UapA, in complex with Xanthine==
-	<StructureSection load='5i6c' size='340' side='right' caption='[[5i6c]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<StructureSection load='5i6c' size='340' side='right'caption='[[5i6c]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i6c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I6C OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5I6C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i6c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_nidulans Aspergillus nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I6C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I6C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5i6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i6c OCA], [http://pdbe.org/5i6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i6c RCSB], [http://www.ebi.ac.uk/pdbsum/5i6c PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uapA, AN6932 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227321 Aspergillus nidulans])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i6c OCA], [http://pdbe.org/5i6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i6c RCSB], [http://www.ebi.ac.uk/pdbsum/5i6c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i6c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5i6c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5i6c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aspergillus nidulans]]
		+	[[Category: Large Structures]]
	[[Category: Alguel, Y]]		[[Category: Alguel, Y]]
	[[Category: Amillis, S]]		[[Category: Amillis, S]]

OCA at 16:48, 10 May 2016

OCA — Tue, 10 May 2016 16:48:04 GMT

←Older revision		Revision as of 16:48, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5i6c is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==The structure of the eukaryotic purine/H+ symporter, UapA, in complex with Xanthine==
		+	<StructureSection load='5i6c' size='340' side='right' caption='[[5i6c]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5i6c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I6C FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i6c OCA], [http://pdbe.org/5i6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i6c RCSB], [http://www.ebi.ac.uk/pdbsum/5i6c PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UAPA_EMENI UAPA_EMENI]] Uric acid-xanthine transporter.<ref>PMID:15953615</ref> <ref>PMID:16096268</ref> <ref>PMID:20002879</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The uric acid/xanthine H(+) symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a genetically stabilized version of UapA (UapA-G411VDelta1-11) in complex with xanthine. UapA is formed from two domains, a core domain and a gate domain, similar to the previously solved uracil transporter UraA, which belongs to the same family. The structure shows UapA in an inward-facing conformation with xanthine bound to residues in the core domain. Unlike UraA, which was observed to be a monomer, UapA forms a dimer in the crystals with dimer interactions formed exclusively through the gate domain. Analysis of dominant negative mutants is consistent with dimerization playing a key role in transport. We postulate that UapA uses an elevator transport mechanism likely to be shared with other structurally homologous transporters including anion exchangers and prestin.

-	~~Authors:~~ Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull~~, N.J.~~, Craven, G., Iwata, S., Armstrong, A., Mikros, E., Diallinas, G., Cameron~~, A.D.~~, Byrne, B.	+	Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.,Alguel Y, Amillis S, Leung J, Lambrinidis G, Capaldi S, Scull NJ, Craven G, Iwata S, Armstrong A, Mikros E, Diallinas G, Cameron AD, Byrne B Nat Commun. 2016 Apr 18;7:11336. doi: 10.1038/ncomms11336. PMID:27088252<ref>PMID:27088252</ref>

-	~~Description: The structure~~ of the ~~eukaryotic purine~~/~~H+ symporter, UapA, in complex with Xanthine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5i6c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Alguel, Y]]		[[Category: Alguel, Y]]
-	[[Category: Iwata, S]]
-	[[Category: Mikros, E]]
-	[[Category: Capaldi, S]]
	[[Category: Amillis, S]]		[[Category: Amillis, S]]
-	[[Category: ~~Scull~~, ~~N.J]]~~	+	[[Category: Armstrong, A]]
-	~~[[Category: Leung, J~~]]	+
	[[Category: Byrne, B]]		[[Category: Byrne, B]]
-	[[Category: Cameron, A.D]]	+	[[Category: Cameron, A D]]
		+	[[Category: Capaldi, S]]
	[[Category: Craven, G]]		[[Category: Craven, G]]
	[[Category: Diallinas, G]]		[[Category: Diallinas, G]]
-	[[Category: ~~Armstrong~~, A]]	+	[[Category: Iwata, S]]
	[[Category: Lambrinidis, G]]		[[Category: Lambrinidis, G]]
		+	[[Category: Leung, J]]
		+	[[Category: Mikros, E]]
		+	[[Category: Scull, N J]]
		+	[[Category: Membrane protein eukaryotic uric acid/xanthine h+ symporter]]
		+	[[Category: Transport protein]]

OCA at 13:26, 2 March 2016

OCA — Wed, 02 Mar 2016 13:26:22 GMT

←Older revision		Revision as of 13:26, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5i6c is ON HOLD	+	The entry 5i6c is ON HOLD until Paper Publication

	Authors: Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull, N.J., Craven, G., Iwata, S., Armstrong, A., Mikros, E., Diallinas, G., Cameron, A.D., Byrne, B.		Authors: Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull, N.J., Craven, G., Iwata, S., Armstrong, A., Mikros, E., Diallinas, G., Cameron, A.D., Byrne, B.

-	Description: The structure of the eukaryotic purine/H+ symporter, UapA, ~~reveals a role for homodimerization~~ in ~~transport activity~~	+	Description: The structure of the eukaryotic purine/H+ symporter, UapA, in complex with Xanthine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Alguel, Y]]		[[Category: Alguel, Y]]

OCA: Protected "5i6c" [edit=sysop:move=sysop]

OCA — Fri, 26 Feb 2016 16:52:14 GMT

Protected "5i6c" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:52, 26 February 2016

OCA: New page: '''Unreleased structure''' The entry 5i6c is ON HOLD Authors: Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull, N.J., Craven, G., Iwata, S., Armstrong, A., Mikros...

OCA — Fri, 26 Feb 2016 16:52:12 GMT

New page: '''Unreleased structure''' The entry 5i6c is ON HOLD Authors: Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull, N.J., Craven, G., Iwata, S., Armstrong, A., Mikros...

New page

'''Unreleased structure'''

The entry 5i6c is ON HOLD

Authors: Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull, N.J., Craven, G., Iwata, S., Armstrong, A., Mikros, E., Diallinas, G., Cameron, A.D., Byrne, B.

Description: The structure of the eukaryotic purine/H+ symporter, UapA, reveals a role for homodimerization in transport activity
[[Category: Unreleased Structures]]
[[Category: Alguel, Y]]
[[Category: Iwata, S]]
[[Category: Mikros, E]]
[[Category: Capaldi, S]]
[[Category: Amillis, S]]
[[Category: Scull, N.J]]
[[Category: Leung, J]]
[[Category: Byrne, B]]
[[Category: Cameron, A.D]]
[[Category: Craven, G]]
[[Category: Diallinas, G]]
[[Category: Armstrong, A]]
[[Category: Lambrinidis, G]]