5i7p - Revision history

OCA at 08:25, 23 August 2023

OCA — Wed, 23 Aug 2023 08:25:59 GMT

←Older revision		Revision as of 08:25, 23 August 2023
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	<StructureSection load='5i7p' size='340' side='right'caption='[[5i7p]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5i7p' size='340' side='right'caption='[[5i7p]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i7p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I7P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5I7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i7p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I7P FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~FKBP1A~~, ~~FKBP1, FKBP12 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.002Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5i7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i7p OCA], [~~http~~://pdbe.org/5i7p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5i7p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5i7p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5i7p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i7p OCA], [https://pdbe.org/5i7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i7p RCSB], [https://www.ebi.ac.uk/pdbsum/5i7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i7p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>	+	[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> [https://www.uniprot.org/uniprot/SLYD_ECOLI SLYD_ECOLI] Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction. SlyD could be involved in Tat-dependent translocation, by binding to the Tat-type signal of folded proteins. The PPIase substrate specificity, carried out with synthetic peptides of the 'suc-Ala-Xaa-Pro-Phe-4NA' type (where Xaa is the AA tested), was found to be Phe > Ala > Leu.<ref>PMID:12100551</ref> <ref>PMID:15569666</ref> <ref>PMID:16388577</ref> <ref>PMID:17720786</ref> <ref>PMID:17215254</ref> <ref>PMID:19356587</ref> Required for lysis of phiX174 infected cells by stabilizing the hydrophobic viral lysis protein E and allowing it to accumulate to the levels required to exert its lytic effect. May act by a chaperone-like mechanism.<ref>PMID:12100551</ref> <ref>PMID:15569666</ref> <ref>PMID:16388577</ref> <ref>PMID:17720786</ref> <ref>PMID:17215254</ref> <ref>PMID:19356587</ref> Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity.<ref>PMID:12100551</ref> <ref>PMID:15569666</ref> <ref>PMID:16388577</ref> <ref>PMID:17720786</ref> <ref>PMID:17215254</ref> <ref>PMID:19356587</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dobbek, H]]	+	[[Category: Dobbek H]]
-	[[Category: Jakob~~, R P~~]]	+	[[Category: Jakob RP]]
-	[[Category: Knappe~~, T A~~]]	+	[[Category: Knappe TA]]
-	[[Category: Schmid~~, F X]]~~	+	[[Category: Schmid FX]]
-	~~[[Category: Insert in flap]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Chimeric protein]]~~	+
-	~~[[Category: Fkbp12]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Prolyl isomerization]]~~	+
-	~~[[Category: Protein design]]~~	+
-	~~[[Category: Slyd~~]]	+

OCA at 07:07, 3 June 2020

OCA — Wed, 03 Jun 2020 07:07:44 GMT

←Older revision		Revision as of 07:07, 3 June 2020
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	==Crystal structure of Fkbp12-IF(SlyD), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlyD==		==Crystal structure of Fkbp12-IF(SlyD), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlyD==
-	<StructureSection load='5i7p' size='340' side='right' caption='[[5i7p]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5i7p' size='340' side='right'caption='[[5i7p]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i7p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I7P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5I7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i7p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I7P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I7P FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5i7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i7p OCA], [http://pdbe.org/5i7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i7p RCSB], [http://www.ebi.ac.uk/pdbsum/5i7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i7p ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FKBP1A, FKBP1, FKBP12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i7p OCA], [http://pdbe.org/5i7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i7p RCSB], [http://www.ebi.ac.uk/pdbsum/5i7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i7p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dobbek, H]]		[[Category: Dobbek, H]]
	[[Category: Jakob, R P]]		[[Category: Jakob, R P]]

OCA at 19:12, 11 March 2017

OCA — Sat, 11 Mar 2017 19:12:46 GMT

←Older revision		Revision as of 19:12, 11 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5i7p is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of Fkbp12-IF(SlyD), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlyD==
-		+	<StructureSection load='5i7p' size='340' side='right' caption='[[5i7p]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5i7p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I7P FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i7p OCA], [http://pdbe.org/5i7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i7p RCSB], [http://www.ebi.ac.uk/pdbsum/5i7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i7p ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dobbek, H]]
		+	[[Category: Jakob, R P]]
		+	[[Category: Knappe, T A]]
		+	[[Category: Schmid, F X]]
		+	[[Category: Insert in flap]]
		+	[[Category: Chaperone]]
		+	[[Category: Chimeric protein]]
		+	[[Category: Fkbp12]]
		+	[[Category: Isomerase]]
		+	[[Category: Prolyl isomerization]]
		+	[[Category: Protein design]]
		+	[[Category: Slyd]]

OCA at 14:13, 15 May 2016

OCA — Sun, 15 May 2016 14:13:18 GMT

←Older revision		Revision as of 14:13, 15 May 2016
Line 3:		Line 3:
	The entry 5i7p is ON HOLD until Paper Publication		The entry 5i7p is ON HOLD until Paper Publication

-	Authors: ~~Jakob, R.P., Knappe, T.A., Dobbek, H., Schmid, F.X.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Dobbek, H]]
-	[[Category: Schmid, F.X]]
-	[[Category: Knappe, T.A]]
-	[[Category: Jakob, R.P]]

OCA at 13:29, 2 March 2016

OCA — Wed, 02 Mar 2016 13:29:29 GMT

←Older revision		Revision as of 13:29, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5i7p is ON HOLD	+	The entry 5i7p is ON HOLD until Paper Publication

	Authors: Jakob, R.P., Knappe, T.A., Dobbek, H., Schmid, F.X.		Authors: Jakob, R.P., Knappe, T.A., Dobbek, H., Schmid, F.X.

OCA: Protected "5i7p" [edit=sysop:move=sysop]

OCA — Fri, 26 Feb 2016 16:56:39 GMT

Protected "5i7p" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:56, 26 February 2016

OCA: New page: '''Unreleased structure''' The entry 5i7p is ON HOLD Authors: Jakob, R.P., Knappe, T.A., Dobbek, H., Schmid, F.X. Description: Category: Unreleased Structures [[Category: Dobbek, ...

OCA — Fri, 26 Feb 2016 16:56:37 GMT

New page: '''Unreleased structure''' The entry 5i7p is ON HOLD Authors: Jakob, R.P., Knappe, T.A., Dobbek, H., Schmid, F.X. Description: Category: Unreleased Structures [[Category: Dobbek, ...

New page

'''Unreleased structure'''

The entry 5i7p is ON HOLD

Authors: Jakob, R.P., Knappe, T.A., Dobbek, H., Schmid, F.X.

Description:
[[Category: Unreleased Structures]]
[[Category: Dobbek, H]]
[[Category: Schmid, F.X]]
[[Category: Knappe, T.A]]
[[Category: Jakob, R.P]]