5idl - Revision history

OCA at 13:46, 30 August 2023

OCA — Wed, 30 Aug 2023 13:46:57 GMT

←Older revision		Revision as of 13:46, 30 August 2023
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	<StructureSection load='5idl' size='340' side='right'caption='[[5idl]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='5idl' size='340' side='right'caption='[[5idl]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5idl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5idl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5idl OCA], [~~http~~://pdbe.org/5idl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5idl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5idl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5idl ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5idl OCA], [https://pdbe.org/5idl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5idl RCSB], [https://www.ebi.ac.uk/pdbsum/5idl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5idl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ereno-Orbea, J]]	+	[[Category: Ereno-Orbea J]]
-	[[Category: Jardine~~, J G~~]]	+	[[Category: Jardine JG]]
-	[[Category: Julien~~, J P~~]]	+	[[Category: Julien JP]]
-	[[Category: Schief~~, W R~~]]	+	[[Category: Schief WR]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Germline-targeting immunogen]]~~	+
-	~~[[Category: Hiv env]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 16:16, 11 December 2019

OCA — Wed, 11 Dec 2019 16:16:48 GMT

←Older revision		Revision as of 16:16, 11 December 2019
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	==Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT8==		==Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT8==
-	<StructureSection load='5idl' size='340' side='right' caption='[[5idl]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='5idl' size='340' side='right'caption='[[5idl]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5idl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5idl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IDL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5idl OCA], [http://pdbe.org/5idl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5idl RCSB], [http://www.ebi.ac.uk/pdbsum/5idl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5idl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5idl OCA], [http://pdbe.org/5idl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5idl RCSB], [http://www.ebi.ac.uk/pdbsum/5idl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5idl ProSAT]</span></td></tr>
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	</div>		</div>
	<div class="pdbe-citations 5idl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5idl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gp120 3D structures\|Gp120 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ereno-Orbea, J]]		[[Category: Ereno-Orbea, J]]
	[[Category: Jardine, J G]]		[[Category: Jardine, J G]]

OCA at 17:37, 15 November 2017

OCA — Wed, 15 Nov 2017 17:37:35 GMT

←Older revision		Revision as of 17:37, 15 November 2017
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 5idl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5idl" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Gp120\|Gp120]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:43, 21 September 2017

OCA — Thu, 21 Sep 2017 04:43:48 GMT

←Older revision		Revision as of 04:43, 21 September 2017
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 5idl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5idl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gp120\|Gp120]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:27, 5 October 2016

OCA — Wed, 05 Oct 2016 21:27:30 GMT

←Older revision		Revision as of 21:27, 5 October 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5idl is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT8==
		+	<StructureSection load='5idl' size='340' side='right' caption='[[5idl]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5idl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IDL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5idl OCA], [http://pdbe.org/5idl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5idl RCSB], [http://www.ebi.ac.uk/pdbsum/5idl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5idl ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor B cells. Critical unmet challenges are to determine whether bnAb precursor naive B cells bind germline-targeting immunogens and occur at sufficient frequency in humans for reliable vaccine responses. Using deep mutational scanning and multitarget optimization, we developed a germline-targeting immunogen (eOD-GT8) for diverse VRC01-class bnAbs. We then used the immunogen to isolate VRC01-class precursor naive B cells from HIV-uninfected donors. Frequencies of true VRC01-class precursors, their structures, and their eOD-GT8 affinities support this immunogen as a candidate human vaccine prime. These methods could be applied to germline targeting for other classes of HIV bnAbs and for Abs to other pathogens.

-	~~Authors~~:	+	HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.,Jardine JG, Kulp DW, Havenar-Daughton C, Sarkar A, Briney B, Sok D, Sesterhenn F, Ereno-Orbea J, Kalyuzhniy O, Deresa I, Hu X, Spencer S, Jones M, Georgeson E, Adachi Y, Kubitz M, deCamp AC, Julien JP, Wilson IA, Burton DR, Crotty S, Schief WR Science. 2016 Mar 25;351(6280):1458-63. doi: 10.1126/science.aad9195. PMID:27013733<ref>PMID:27013733</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5idl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ereno-Orbea, J]]
		+	[[Category: Jardine, J G]]
		+	[[Category: Julien, J P]]
		+	[[Category: Schief, W R]]
		+	[[Category: Wilson, I A]]
		+	[[Category: Germline-targeting immunogen]]
		+	[[Category: Hiv env]]
		+	[[Category: Viral protein]]

OCA at 14:21, 15 May 2016

OCA — Sun, 15 May 2016 14:21:15 GMT

←Older revision		Revision as of 14:21, 15 May 2016
Line 3:		Line 3:
	The entry 5idl is ON HOLD until Paper Publication		The entry 5idl is ON HOLD until Paper Publication

-	Authors: ~~Julien, J.P., Ereno-Orbea, J., Jardine, J.G., Schief, W.R., Wilson, I.A.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Schief, W.R]]
-	[[Category: Ereno-Orbea, J]]
-	[[Category: Wilson, I.A]]
-	[[Category: Julien, J.P]]
-	[[Category: Jardine, J.G]]

OCA at 00:25, 11 May 2016

OCA — Wed, 11 May 2016 00:25:02 GMT

←Older revision		Revision as of 00:25, 11 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5idl is ON HOLD	+	The entry 5idl is ON HOLD until Paper Publication

	Authors: Julien, J.P., Ereno-Orbea, J., Jardine, J.G., Schief, W.R., Wilson, I.A.		Authors: Julien, J.P., Ereno-Orbea, J., Jardine, J.G., Schief, W.R., Wilson, I.A.

OCA: Protected "5idl" [edit=sysop:move=sysop]

OCA — Wed, 02 Mar 2016 13:47:47 GMT

Protected "5idl" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:47, 2 March 2016

OCA: New page: '''Unreleased structure''' The entry 5idl is ON HOLD Authors: Julien, J.P., Ereno-Orbea, J., Jardine, J.G., Schief, W.R., Wilson, I.A. Description: Category: Unreleased Structures...

OCA — Wed, 02 Mar 2016 13:47:45 GMT

New page: '''Unreleased structure''' The entry 5idl is ON HOLD Authors: Julien, J.P., Ereno-Orbea, J., Jardine, J.G., Schief, W.R., Wilson, I.A. Description: Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 5idl is ON HOLD

Authors: Julien, J.P., Ereno-Orbea, J., Jardine, J.G., Schief, W.R., Wilson, I.A.

Description:
[[Category: Unreleased Structures]]
[[Category: Schief, W.R]]
[[Category: Ereno-Orbea, J]]
[[Category: Wilson, I.A]]
[[Category: Julien, J.P]]
[[Category: Jardine, J.G]]