5igz - Revision history

OCA at 13:52, 30 August 2023

OCA — Wed, 30 Aug 2023 13:52:14 GMT

←Older revision		Revision as of 13:52, 30 August 2023
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	<StructureSection load='5igz' size='340' side='right'caption='[[5igz]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5igz' size='340' side='right'caption='[[5igz]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5igz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IGZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5igz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IGZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=GDP:GUANOSINE~~-~~5-DIPHOSPHATE'>GDP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPR:SPIRAMYCIN+I'>SPR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5igu\|5igu]], [[5igv\|5igv]], [[5igw\|5igw]], [[5igy\|5igy]], [[5ih0\|5ih0]], [[5ih1\|5ih1]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPR:SPIRAMYCIN+I'>SPR</scene></td></tr>
-	<~~tr id~~='~~gene~~'><~~td class="sblockLbl"~~><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">mphB, pO103_99 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5igz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igz OCA], [https://pdbe.org/5igz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5igz RCSB], [https://www.ebi.ac.uk/pdbsum/5igz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5igz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5igz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igz OCA], [~~http~~://pdbe.org/5igz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5igz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5igz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5igz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O32553_ECOLX O32553_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berghuis~~, A M~~]]	+	[[Category: Berghuis AM]]
-	[[Category: Fong~~, D H]]~~	+	[[Category: Fong DH]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Macrolide phosphotransferase]]~~	+
-	~~[[Category: Transferase-antibiotic complex~~]]	+

OCA at 08:05, 8 January 2020

OCA — Wed, 08 Jan 2020 08:05:11 GMT

←Older revision		Revision as of 08:05, 8 January 2020
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	==Macrolide 2'-phosphotransferase type II - complex with GDP and spiramycin==		==Macrolide 2'-phosphotransferase type II - complex with GDP and spiramycin==
-	<StructureSection load='5igz' size='340' side='right' caption='[[5igz]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5igz' size='340' side='right'caption='[[5igz]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5igz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IGZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5igz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IGZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPR:SPIRAMYCIN+I'>SPR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPR:SPIRAMYCIN+I'>SPR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5igu\|5igu]], [[5igv\|5igv]], [[5igw\|5igw]], [[5igy\|5igy]], [[5ih0\|5ih0]], [[5ih1\|5ih1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5igu\|5igu]], [[5igv\|5igv]], [[5igw\|5igw]], [[5igy\|5igy]], [[5ih0\|5ih0]], [[5ih1\|5ih1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mphB, pO103_99 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5igz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igz OCA], [http://pdbe.org/5igz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5igz RCSB], [http://www.ebi.ac.uk/pdbsum/5igz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5igz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5igz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igz OCA], [http://pdbe.org/5igz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5igz RCSB], [http://www.ebi.ac.uk/pdbsum/5igz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5igz ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphotransferase\|Phosphotransferase]]	+	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Fong, D H]]		[[Category: Fong, D H]]

OCA at 07:06, 6 October 2017

OCA — Fri, 06 Oct 2017 07:06:23 GMT

←Older revision		Revision as of 07:06, 6 October 2017
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	</div>		</div>
	<div class="pdbe-citations 5igz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5igz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphotransferase\|Phosphotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:21, 4 May 2017

OCA — Thu, 04 May 2017 06:21:27 GMT

←Older revision		Revision as of 06:21, 4 May 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5igz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igz OCA], [http://pdbe.org/5igz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5igz RCSB], [http://www.ebi.ac.uk/pdbsum/5igz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5igz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5igz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igz OCA], [http://pdbe.org/5igz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5igz RCSB], [http://www.ebi.ac.uk/pdbsum/5igz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5igz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The macrolides are a class of antibiotic, characterized by a large macrocyclic lactone ring that can be inactivated by macrolide phosphotransferase enzymes. We present structures for MPH(2')-I and MPH(2')-II in the apo state, and in complex with GTP analogs and six different macrolides. These represent the first structures from the two main classes of macrolide phosphotransferases. The structures show that the enzymes are related to the aminoglycoside phosphotransferases, but are distinguished from them by the presence of a large interdomain linker that contributes to an expanded antibiotic binding pocket. This pocket is largely hydrophobic, with a negatively charged patch located at a conserved aspartate residue, rationalizing the broad-spectrum resistance conferred by the enzymes. Complementary mutation studies provide insights into factors governing substrate specificity. A comparison with macrolides bound to their natural target, the 50S ribosome, suggests avenues for next-generation antibiotic development.
		+
		+	Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.,Fong DH, Burk DL, Blanchet J, Yan AY, Berghuis AM Structure. 2017 May 2;25(5):750-761.e5. doi: 10.1016/j.str.2017.03.007. Epub 2017, Apr 13. PMID:28416110<ref>PMID:28416110</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5igz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:57, 27 April 2017

OCA — Thu, 27 Apr 2017 13:57:16 GMT

←Older revision		Revision as of 13:57, 27 April 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5igz is ~~ON HOLD until May 31 2018~~	+	==Macrolide 2'-phosphotransferase type II - complex with GDP and spiramycin==
-		+	<StructureSection load='5igz' size='340' side='right' caption='[[5igz]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5igz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IGZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPR:SPIRAMYCIN+I'>SPR</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5igu\|5igu]], [[5igv\|5igv]], [[5igw\|5igw]], [[5igy\|5igy]], [[5ih0\|5ih0]], [[5ih1\|5ih1]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5igz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igz OCA], [http://pdbe.org/5igz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5igz RCSB], [http://www.ebi.ac.uk/pdbsum/5igz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5igz ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Berghuis, A M]]
		+	[[Category: Fong, D H]]
		+	[[Category: Kinase]]
		+	[[Category: Macrolide phosphotransferase]]
		+	[[Category: Transferase-antibiotic complex]]

OCA at 09:35, 9 March 2017

OCA — Thu, 09 Mar 2017 09:35:02 GMT

←Older revision		Revision as of 09:35, 9 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5igz is ON HOLD until ~~Paper Publication~~	+	The entry 5igz is ON HOLD until May 31 2018

	Authors:		Authors:

OCA at 14:25, 15 May 2016

OCA — Sun, 15 May 2016 14:25:19 GMT

←Older revision		Revision as of 14:25, 15 May 2016
Line 3:		Line 3:
	The entry 5igz is ON HOLD until Paper Publication		The entry 5igz is ON HOLD until Paper Publication

-	Authors: ~~Berghuis, A.M., Fong, D.H.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Berghuis, A.M]]
-	[[Category: Fong, D.H]]

OCA at 00:29, 11 May 2016

OCA — Wed, 11 May 2016 00:29:34 GMT

←Older revision		Revision as of 00:29, 11 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5igz is ON HOLD	+	The entry 5igz is ON HOLD until Paper Publication

	Authors: Berghuis, A.M., Fong, D.H.		Authors: Berghuis, A.M., Fong, D.H.

OCA: Protected "5igz" [edit=sysop:move=sysop]

OCA — Thu, 10 Mar 2016 02:17:59 GMT

Protected "5igz" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:17, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5igz is ON HOLD Authors: Berghuis, A.M., Fong, D.H. Description: Category: Unreleased Structures Category: Berghuis, A.M [[Category: Fong,...

OCA — Thu, 10 Mar 2016 02:17:57 GMT

New page: '''Unreleased structure''' The entry 5igz is ON HOLD Authors: Berghuis, A.M., Fong, D.H. Description: Category: Unreleased Structures Category: Berghuis, A.M [[Category: Fong,...

New page

'''Unreleased structure'''

The entry 5igz is ON HOLD

Authors: Berghuis, A.M., Fong, D.H.

Description:
[[Category: Unreleased Structures]]
[[Category: Berghuis, A.M]]
[[Category: Fong, D.H]]