5ih6 - Revision history

OCA at 13:52, 30 August 2023

OCA — Wed, 30 Aug 2023 13:52:27 GMT

←Older revision		Revision as of 13:52, 30 August 2023
Line 1:		Line 1:

	==Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative==		==Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative==
-	<StructureSection load='5ih6' size='340' side='right' caption='[[5ih6]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5ih6' size='340' side='right'caption='[[5ih6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ih6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IH6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ih6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IH6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AUG:6-(3-BROMOPHENYL)PTERIDINE-2,4,7-TRIAMINE'>AUG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CSNK1D, HCKID ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AUG:6-(3-BROMOPHENYL)PTERIDINE-2,4,7-TRIAMINE'>AUG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ih6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ih6 OCA], [~~http~~://pdbe.org/5ih6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ih6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ih6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ih6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ih6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ih6 OCA], [https://pdbe.org/5ih6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ih6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ih6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ih6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/KC1D_HUMAN KC1D_HUMAN]] Familial advanced sleep-phase syndrome. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/KC1D_HUMAN KC1D_HUMAN] Familial advanced sleep-phase syndrome. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KC1D_HUMAN KC1D_HUMAN]] Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.<ref>PMID:10606744</ref> <ref>PMID:12270943</ref> <ref>PMID:14761950</ref> <ref>PMID:16027726</ref> <ref>PMID:17962809</ref> <ref>PMID:17562708</ref> <ref>PMID:19043076</ref> <ref>PMID:19339517</ref> <ref>PMID:20637175</ref> <ref>PMID:20041275</ref> <ref>PMID:20048001</ref> <ref>PMID:20699359</ref> <ref>PMID:20696890</ref> <ref>PMID:20407760</ref> <ref>PMID:21084295</ref> <ref>PMID:21422228</ref>	+	[https://www.uniprot.org/uniprot/KC1D_HUMAN KC1D_HUMAN] Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.<ref>PMID:10606744</ref> <ref>PMID:12270943</ref> <ref>PMID:14761950</ref> <ref>PMID:16027726</ref> <ref>PMID:17962809</ref> <ref>PMID:17562708</ref> <ref>PMID:19043076</ref> <ref>PMID:19339517</ref> <ref>PMID:20637175</ref> <ref>PMID:20041275</ref> <ref>PMID:20048001</ref> <ref>PMID:20699359</ref> <ref>PMID:20696890</ref> <ref>PMID:20407760</ref> <ref>PMID:21084295</ref> <ref>PMID:21422228</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5ih6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ih6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Casein kinase 3D structures\|Casein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Brockmeyer, A]]	+	[[Category: Large Structures]]
-	[[Category: Illich~~, D J~~]]	+	[[Category: Brockmeyer A]]
-	[[Category: Janning, P]]	+	[[Category: Illich DJ]]
-	[[Category: Osada, H]]	+	[[Category: Janning P]]
-	[[Category: Porfetye~~, A T~~]]	+	[[Category: Osada H]]
-	[[Category: Schoeler~~, H R~~]]	+	[[Category: Porfetye AT]]
-	[[Category: Takemoto, Y]]	+	[[Category: Schoeler HR]]
-	[[Category: Ursu, A]]	+	[[Category: Takemoto Y]]
-	[[Category: Vetter~~, I R~~]]	+	[[Category: Ursu A]]
-	[[Category: Waldmann, H]]	+	[[Category: Vetter IR]]
-	[[Category: Watanabe, N]]	+	[[Category: Waldmann H]]
-	[[Category: Zhang, M]]	+	[[Category: Watanabe N]]
-	[[Category: Ziegler, S]]	+	[[Category: Zhang M]]
-	~~[[Category: Kinase domain]]~~	+	[[Category: Ziegler S]]
-	~~[[Category: Kinase inhibitor complex]]~~	+
-	~~[[Category: Stem cell reprogramming]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 13:36, 16 November 2017

OCA — Thu, 16 Nov 2017 13:36:23 GMT

←Older revision		Revision as of 13:36, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='5ih6' size='340' side='right' caption='[[5ih6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5ih6' size='340' side='right' caption='[[5ih6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ih6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ih6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IH6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AUG:6-(3-BROMOPHENYL)PTERIDINE-2,4,7-TRIAMINE'>AUG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AUG:6-(3-BROMOPHENYL)PTERIDINE-2,4,7-TRIAMINE'>AUG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ih6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ih6 OCA], [http://pdbe.org/5ih6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ih6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ih6 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CSNK1D, HCKID ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ih6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ih6 OCA], [http://pdbe.org/5ih6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ih6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ih6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ih6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Brockmeyer, A]]		[[Category: Brockmeyer, A]]
	[[Category: Illich, D J]]		[[Category: Illich, D J]]

OCA at 17:28, 10 May 2016

OCA — Tue, 10 May 2016 17:28:21 GMT

←Older revision		Revision as of 17:28, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~5ih6~~ is ~~ON HOLD~~	+	==Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative==
		+	<StructureSection load='5ih6' size='340' side='right' caption='[[5ih6]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ih6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IH6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AUG:6-(3-BROMOPHENYL)PTERIDINE-2,4,7-TRIAMINE'>AUG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ih6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ih6 OCA], [http://pdbe.org/5ih6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ih6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ih6 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/KC1D_HUMAN KC1D_HUMAN]] Familial advanced sleep-phase syndrome. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KC1D_HUMAN KC1D_HUMAN]] Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.<ref>PMID:10606744</ref> <ref>PMID:12270943</ref> <ref>PMID:14761950</ref> <ref>PMID:16027726</ref> <ref>PMID:17962809</ref> <ref>PMID:17562708</ref> <ref>PMID:19043076</ref> <ref>PMID:19339517</ref> <ref>PMID:20637175</ref> <ref>PMID:20041275</ref> <ref>PMID:20048001</ref> <ref>PMID:20699359</ref> <ref>PMID:20696890</ref> <ref>PMID:20407760</ref> <ref>PMID:21084295</ref> <ref>PMID:21422228</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The discovery of novel small molecules that induce stem cell reprogramming and give efficient access to pluripotent stem cells is of major importance for potential therapeutic applications and may reveal novel insights into the factors controlling pluripotency. Chemical reprogramming of mouse epiblast stem cells (EpiSCs) into cells corresponding to embryonic stem cells (cESCs) is an inefficient process. In order to identify small molecules that promote this cellular transition, we analyzed the LOPAC library in a phenotypic screen monitoring Oct4-GFP expression and identified triamterene (TR) as initial hit. Synthesis of a TR-derived compound collection and investigation for reprogramming of EpiSCs into cESCs identified casein kinases 1 (CK1) alpha/delta/varepsilon as responsible cellular targets of TR and unraveled the structural parameters that determine reprogramming. Delineation of a structure-activity relationship led to the development of Epiblastin A, which engages CK1 isoenzymes in cell lysate and induces efficient conversion of EpiSCs into cESCs.

-	~~Authors: Ursu,~~ A., Illich~~, D.J.~~, Takemoto, Y., Porfetye~~, A.T.~~, Zhang, M., Brockmeyer, A., Janning, P., Watanabe, N., Osada, H., Vetter~~, I.R.~~, Ziegler, S., ~~Schoeler~~, H.R., ~~Waldmann, H~~.	+	Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.,Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Scholer HR, Waldmann H Cell Chem Biol. 2016 Apr 21;23(4):494-507. doi: 10.1016/j.chembiol.2016.02.015., Epub 2016 Mar 31. PMID:27049670<ref>PMID:27049670</ref>

-	~~Description: Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Watanabe, N]]~~	+	<div class="pdbe-citations 5ih6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Brockmeyer, A]]		[[Category: Brockmeyer, A]]
-	[[Category: ~~Waldmann~~, ~~H]]~~	+	[[Category: Illich, D J]]
-	~~[[Category: Porfetye, A.T]]~~	+
-	~~[[Category: Osada, H~~]]	+
	[[Category: Janning, P]]		[[Category: Janning, P]]
-	[[Category: ~~Vetter~~, ~~I.R~~]]	+	[[Category: Osada, H]]
-	[[Category: ~~Ziegler~~, ~~S]]~~	+	[[Category: Porfetye, A T]]
-	~~[[Category: Zhang, M~~]]	+	[[Category: Schoeler, H R]]
-	[[Category: Schoeler, H.R]]	+
-	~~[[Category: Illich, D.J]]~~	+
-	~~[[Category: Ursu, A~~]]	+
	[[Category: Takemoto, Y]]		[[Category: Takemoto, Y]]
		+	[[Category: Ursu, A]]
		+	[[Category: Vetter, I R]]
		+	[[Category: Waldmann, H]]
		+	[[Category: Watanabe, N]]
		+	[[Category: Zhang, M]]
		+	[[Category: Ziegler, S]]
		+	[[Category: Kinase domain]]
		+	[[Category: Kinase inhibitor complex]]
		+	[[Category: Stem cell reprogramming]]
		+	[[Category: Transferase]]

OCA: Protected "5ih6" [edit=sysop:move=sysop]

OCA — Thu, 10 Mar 2016 02:19:03 GMT

Protected "5ih6" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:19, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5ih6 is ON HOLD Authors: Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang, M., Brockmeyer, A., Janning, P., Watanabe, N., Osada, H., Vett...

OCA — Thu, 10 Mar 2016 02:19:01 GMT

New page: '''Unreleased structure''' The entry 5ih6 is ON HOLD Authors: Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang, M., Brockmeyer, A., Janning, P., Watanabe, N., Osada, H., Vett...

New page

'''Unreleased structure'''

The entry 5ih6 is ON HOLD

Authors: Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang, M., Brockmeyer, A., Janning, P., Watanabe, N., Osada, H., Vetter, I.R., Ziegler, S., Schoeler, H.R., Waldmann, H.

Description: Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A derivative
[[Category: Unreleased Structures]]
[[Category: Watanabe, N]]
[[Category: Brockmeyer, A]]
[[Category: Waldmann, H]]
[[Category: Porfetye, A.T]]
[[Category: Osada, H]]
[[Category: Janning, P]]
[[Category: Vetter, I.R]]
[[Category: Ziegler, S]]
[[Category: Zhang, M]]
[[Category: Schoeler, H.R]]
[[Category: Illich, D.J]]
[[Category: Ursu, A]]
[[Category: Takemoto, Y]]