5ihz - Revision history

OCA at 13:53, 30 August 2023

OCA — Wed, 30 Aug 2023 13:53:34 GMT

←Older revision		Revision as of 13:53, 30 August 2023
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	<StructureSection load='5ihz' size='340' side='right'caption='[[5ihz]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='5ihz' size='340' side='right'caption='[[5ihz]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ihz]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ihz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IHZ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5ig7\|5ig7]]~~, [[~~5ijk~~\|~~5ijk]], [[5ifj\|5ifj~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.64Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [~~http~~://pdbe.org/5ihz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [https://pdbe.org/5ihz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [https://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, X]]	+	[[Category: Chen X]]
-	[[Category: Gidoni, M]]	+	[[Category: Gidoni M]]
-	[[Category: Lundin~~, K E]]~~	+	[[Category: Lundin KE]]
-	~~[[Category: Pre, M F.du~~]]	+	[[Category: Snir O]]
-	[[Category: Snir, O]]	+	[[Category: Sollid LM]]
-	[[Category: Sollid~~, L M~~]]	+	[[Category: Steinsbo O]]
-	[[Category: Steinsbo, O]]	+	[[Category: Yaari G]]
-	[[Category: Yaari, G]]	+	[[Category: Zhao Y]]
-	[[Category: Zhao, Y]]	+	[[Category: Du Pre MF]]
-	[[Category: ~~Anti-gliadin antibody]]~~	+
-	~~[[Category: Celiac disease]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 07:19, 3 June 2020

OCA — Wed, 03 Jun 2020 07:19:07 GMT

←Older revision		Revision as of 07:19, 3 June 2020
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	==Crystal structure of anti-gliadin 1002-1E01 Fab fragment==		==Crystal structure of anti-gliadin 1002-1E01 Fab fragment==
-	<StructureSection load='5ihz' size='340' side='right' caption='[[5ihz]], [[Resolution\|resolution]] 1.64Å' scene=''>	+	<StructureSection load='5ihz' size='340' side='right'caption='[[5ihz]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ihz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ihz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IHZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig7\|5ig7]], [[5ijk\|5ijk]], [[5ifj\|5ifj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig7\|5ig7]], [[5ijk\|5ijk]], [[5ifj\|5ifj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [http://pdbe.org/5ihz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [http://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [http://pdbe.org/5ihz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [http://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
	[[Category: Gidoni, M]]		[[Category: Gidoni, M]]

OCA at 07:36, 6 December 2017

OCA — Wed, 06 Dec 2017 07:36:02 GMT

←Older revision		Revision as of 07:36, 6 December 2017
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	<StructureSection load='5ihz' size='340' side='right' caption='[[5ihz]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='5ihz' size='340' side='right' caption='[[5ihz]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ihz]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ihz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IHZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig7\|5ig7]], [[5ijk\|5ijk]], [[5ifj\|5ifj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig7\|5ig7]], [[5ijk\|5ijk]], [[5ifj\|5ifj]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [http://pdbe.org/5ihz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [http://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [http://pdbe.org/5ihz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [http://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
-	[[Category: ~~Harlos~~, K]]	+	[[Category: Gidoni, M]]
		+	[[Category: Lundin, K E]]
		+	[[Category: Pre, M F.du]]
	[[Category: Snir, O]]		[[Category: Snir, O]]
	[[Category: Sollid, L M]]		[[Category: Sollid, L M]]
		+	[[Category: Steinsbo, O]]
		+	[[Category: Yaari, G]]
	[[Category: Zhao, Y]]		[[Category: Zhao, Y]]
	[[Category: Anti-gliadin antibody]]		[[Category: Anti-gliadin antibody]]
	[[Category: Celiac disease]]		[[Category: Celiac disease]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 09:30, 4 October 2017

OCA — Wed, 04 Oct 2017 09:30:09 GMT

←Older revision		Revision as of 09:30, 4 October 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [http://pdbe.org/5ihz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [http://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [http://pdbe.org/5ihz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [http://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The role of B cells and posttranslational modifications in pathogenesis of organ-specific immune diseases is increasingly envisioned but remains poorly understood, particularly in human disorders. In celiac disease, transglutaminase 2-modified (TG2-modified; deamidated) gluten peptides drive disease-specific T cell and B cell responses, and antibodies to deamidated gluten peptides are excellent diagnostic markers. Here, we substantiate by high-throughput sequencing of IGHV genes that antibodies to a disease-specific, deamidated, and immunodominant B cell epitope of gluten (PLQPEQPFP) have biased and stereotyped usage of IGHV3-23 and IGHV3-15 gene segments with modest somatic mutations. X-ray crystal structures of 2 prototype IGHV3-15/IGKV4-1 and IGHV3-23/IGLV4-69 antibodies reveal peptide interaction mainly via germline-encoded residues. In-depth mutational analysis showed restricted selection and substitution patterns at positions involved in antigen binding. While the IGHV3-15/IGKV4-1 antibody interacts with Glu5 and Gln6, the IGHV3-23/IGLV4-69 antibody interacts with Gln3, Pro4, Pro7, and Phe8 - residues involved in substrate recognition by TG2. Hence, both antibodies, despite different interaction with the epitope, recognize signatures of TG2 processing that facilitates B cell presentation of deamidated gluten peptides to T cells, thereby providing a molecular framework for the generation of these clinically important antibodies. The study provides essential insight into the pathogenic mechanism of celiac disease.
		+
		+	Stereotyped antibody responses target posttranslationally modified gluten in celiac disease.,Snir O, Chen X, Gidoni M, du Pre MF, Zhao Y, Steinsbo O, Lundin KE, Yaari G, Sollid LM JCI Insight. 2017 Sep 7;2(17). pii: 93961. doi: 10.1172/jci.insight.93961. PMID:28878138<ref>PMID:28878138</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ihz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:17, 15 March 2017

OCA — Wed, 15 Mar 2017 21:17:33 GMT

←Older revision		Revision as of 21:17, 15 March 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5ihz is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of anti-gliadin 1002-1E01 Fab fragment==
-		+	<StructureSection load='5ihz' size='340' side='right' caption='[[5ihz]], [[Resolution\|resolution]] 1.64Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ihz]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IHZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig7\|5ig7]], [[5ijk\|5ijk]], [[5ifj\|5ifj]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ihz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ihz OCA], [http://pdbe.org/5ihz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ihz RCSB], [http://www.ebi.ac.uk/pdbsum/5ihz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ihz ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, X]]
		+	[[Category: Harlos, K]]
		+	[[Category: Snir, O]]
		+	[[Category: Sollid, L M]]
		+	[[Category: Zhao, Y]]
		+	[[Category: Anti-gliadin antibody]]
		+	[[Category: Celiac disease]]
		+	[[Category: Immune system]]

OCA at 10:14, 18 January 2017

OCA — Wed, 18 Jan 2017 10:14:27 GMT

←Older revision		Revision as of 10:14, 18 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ihz is ON HOLD	+	The entry 5ihz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 11:26, 2 January 2017

OCA — Mon, 02 Jan 2017 11:26:48 GMT

←Older revision		Revision as of 11:26, 2 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ihz is ON HOLD ~~until Paper Publication~~	+	The entry 5ihz is ON HOLD

	Authors:		Authors:

OCA at 14:26, 15 May 2016

OCA — Sun, 15 May 2016 14:26:37 GMT

←Older revision		Revision as of 14:26, 15 May 2016
Line 3:		Line 3:
	The entry 5ihz is ON HOLD until Paper Publication		The entry 5ihz is ON HOLD until Paper Publication

-	Authors: ~~Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Snir, O]]
-	[[Category: Sollid, L.M]]
-	[[Category: Chen, X]]
-	[[Category: Harlos, K]]
-	[[Category: Zhao, Y]]

OCA at 00:30, 11 May 2016

OCA — Wed, 11 May 2016 00:30:55 GMT

←Older revision		Revision as of 00:30, 11 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ihz is ON HOLD	+	The entry 5ihz is ON HOLD until Paper Publication

-	Authors: Xi Chen, ~~Yuguang~~ Zhao, ~~Karl~~ Harlos, ~~Jingshan Ren~~, ~~Omri~~ Snir, ~~Ludvig M~~.Sollid	+	Authors: Chen, X., Zhao, Y., Harlos, K., Snir, O., Sollid, L.M.

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Xi Chen~~, ~~Yuguang Zhao~~, ~~Karl~~ Harlos, ~~Jingshan Ren~~, ~~Omri Snir, Ludvig M.Sollid~~]]	+	[[Category: Snir, O]]
		+	[[Category: Sollid, L.M]]
		+	[[Category: Chen, X]]
		+	[[Category: Harlos, K]]
		+	[[Category: Zhao, Y]]

OCA: Protected "5ihz" [edit=sysop:move=sysop]

OCA — Thu, 10 Mar 2016 02:21:26 GMT

Protected "5ihz" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:21, 10 March 2016