5iie - Revision history

OCA at 13:54, 30 August 2023

OCA — Wed, 30 Aug 2023 13:54:05 GMT

←Older revision		Revision as of 13:54, 30 August 2023
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	<StructureSection load='5iie' size='340' side='right'caption='[[5iie]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5iie' size='340' side='right'caption='[[5iie]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iie]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iie]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IIE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iie OCA], [~~http~~://pdbe.org/5iie PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iie RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iie PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iie ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iie OCA], [https://pdbe.org/5iie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iie RCSB], [https://www.ebi.ac.uk/pdbsum/5iie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iie ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Haynes~~, B F~~]]	+	[[Category: Haynes BF]]
-	[[Category: Nicely~~, N I]]~~	+	[[Category: Nicely NI]]
-	~~[[Category: Hiv-1 antibody gp120]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 09:07, 4 December 2019

OCA — Wed, 04 Dec 2019 09:07:56 GMT

←Older revision		Revision as of 09:07, 4 December 2019
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	==STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3==		==STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3==
-	<StructureSection load='5iie' size='340' side='right' caption='[[5iie]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='5iie' size='340' side='right'caption='[[5iie]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5iie]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IIE FirstGlance]. <br>		<table><tr><td colspan='2'>[[5iie]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IIE FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iie OCA], [http://pdbe.org/5iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iie RCSB], [http://www.ebi.ac.uk/pdbsum/5iie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iie ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iie OCA], [http://pdbe.org/5iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iie RCSB], [http://www.ebi.ac.uk/pdbsum/5iie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iie ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antibodies to the V3-glycan bnAb binding site, we repetitively immunized macaques over a 4-year period with an Env expressing V3-high mannose glycans. Env immunizations elicited plasma antibodies that neutralized HIV-1 expressing only high-mannose glycans-a characteristic shared by early bnAb B cell lineage members. A rhesus recombinant monoclonal antibody from a vaccinated macaque bound to the V3-glycan site at the same amino acids as broadly neutralizing antibodies. A structure of the antibody bound to glycan revealed that the three variable heavy-chain complementarity-determining regions formed a cavity into which glycan could insert and neutralized multiple HIV-1 isolates with high-mannose glycans. Thus, HIV-1 Env vaccination induced mannose-dependent antibodies with characteristics of V3-glycan bnAb precursors.
		+
		+	Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates.,Saunders KO, Nicely NI, Wiehe K, Bonsignori M, Meyerhoff RR, Parks R, Walkowicz WE, Aussedat B, Wu NR, Cai F, Vohra Y, Park PK, Eaton A, Go EP, Sutherland LL, Scearce RM, Barouch DH, Zhang R, Von Holle T, Overman RG, Anasti K, Sanders RW, Moody MA, Kepler TB, Korber B, Desaire H, Santra S, Letvin NL, Nabel GJ, Montefiori DC, Tomaras GD, Liao HX, Alam SM, Danishefsky SJ, Haynes BF Cell Rep. 2017 Feb 28;18(9):2175-2188. doi: 10.1016/j.celrep.2017.02.003. PMID:28249163<ref>PMID:28249163</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5iie" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Haynes, B F]]		[[Category: Haynes, B F]]
	[[Category: Nicely, N I]]		[[Category: Nicely, N I]]
	[[Category: Hiv-1 antibody gp120]]		[[Category: Hiv-1 antibody gp120]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 12:51, 6 November 2017

OCA — Mon, 06 Nov 2017 12:51:20 GMT

←Older revision		Revision as of 12:51, 6 November 2017
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	<StructureSection load='5iie' size='340' side='right' caption='[[5iie]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5iie' size='340' side='right' caption='[[5iie]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iie]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IIE FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iie OCA], [http://pdbe.org/5iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iie RCSB], [http://www.ebi.ac.uk/pdbsum/5iie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iie ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iie OCA], [http://pdbe.org/5iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iie RCSB], [http://www.ebi.ac.uk/pdbsum/5iie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iie ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Haynes, B F]]		[[Category: Haynes, B F]]
	[[Category: Nicely, N I]]		[[Category: Nicely, N I]]
	[[Category: Hiv-1 antibody gp120]]		[[Category: Hiv-1 antibody gp120]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 09:33, 11 March 2017

OCA — Sat, 11 Mar 2017 09:33:55 GMT

←Older revision		Revision as of 09:33, 11 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5iie is ~~ON HOLD until Paper Publication~~	+	==STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3==
		+	<StructureSection load='5iie' size='340' side='right' caption='[[5iie]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5iie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IIE FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iie OCA], [http://pdbe.org/5iie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iie RCSB], [http://www.ebi.ac.uk/pdbsum/5iie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iie ProSAT]</span></td></tr>
		+	</table>

-	~~Authors: Nicely, N.I., Haynes, B.F.~~	+	==See Also==
-		+	*[[3D structures of antibody\|3D structures of antibody]]
-	~~Description: STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3~~	+	__TOC__
-	[[~~Category: Unreleased Structures~~]]	+	</StructureSection>
-	[[Category: Haynes, B.F]]	+	[[Category: Haynes, B F]]
-	[[Category: Nicely, N.I]]	+	[[Category: Nicely, N I]]
		+	[[Category: Hiv-1 antibody gp120]]
		+	[[Category: Immune system]]

OCA at 10:14, 18 January 2017

OCA — Wed, 18 Jan 2017 10:14:57 GMT

←Older revision		Revision as of 10:14, 18 January 2017
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	Authors: Nicely, N.I., Haynes, B.F.		Authors: Nicely, N.I., Haynes, B.F.

-	Description: ~~Structure of unliganded anti~~-HIV ~~antibody~~ DH501 ~~that binds gp120~~ V3	+	Description: STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Haynes, B.F]]		[[Category: Haynes, B.F]]
	[[Category: Nicely, N.I]]		[[Category: Nicely, N.I]]

OCA at 00:31, 11 May 2016

OCA — Wed, 11 May 2016 00:31:42 GMT

←Older revision		Revision as of 00:31, 11 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5iie is ON HOLD	+	The entry 5iie is ON HOLD until Paper Publication

	Authors: Nicely, N.I., Haynes, B.F.		Authors: Nicely, N.I., Haynes, B.F.

OCA: Protected "5iie" [edit=sysop:move=sysop]

OCA — Thu, 10 Mar 2016 02:22:32 GMT

Protected "5iie" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:22, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5iie is ON HOLD Authors: Nicely, N.I., Haynes, B.F. Description: Structure of unliganded anti-HIV antibody DH501 that binds gp120 V3 [[Category: Un...

OCA — Thu, 10 Mar 2016 02:22:31 GMT

New page: '''Unreleased structure''' The entry 5iie is ON HOLD Authors: Nicely, N.I., Haynes, B.F. Description: Structure of unliganded anti-HIV antibody DH501 that binds gp120 V3 [[Category: Un...

New page

'''Unreleased structure'''

The entry 5iie is ON HOLD

Authors: Nicely, N.I., Haynes, B.F.

Description: Structure of unliganded anti-HIV antibody DH501 that binds gp120 V3
[[Category: Unreleased Structures]]
[[Category: Haynes, B.F]]
[[Category: Nicely, N.I]]