5iih - Revision history

OCA at 09:34, 27 September 2023

OCA — Wed, 27 Sep 2023 09:34:22 GMT

←Older revision		Revision as of 09:34, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5iih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[5iih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IIH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[5hoz\|5hoz]]~~, ~~[[3v08\|3v08]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [https://pdbe.org/5iih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [https://www.ebi.ac.uk/pdbsum/5iih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [https://pdbe.org/5iih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [https://www.ebi.ac.uk/pdbsum/5iih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ALBU_HORSE ALBU_HORSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 28:
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Almo~~, S C~~]]	+	[[Category: Almo SC]]
-	[[Category: Cooper~~, D R~~]]	+	[[Category: Cooper DR]]
-	[[Category: Handing~~, K B~~]]	+	[[Category: Handing KB]]
-	[[Category: Minor, W]]	+	[[Category: Minor W]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shabalin IG]]
-	[[Category: Shabalin~~, I G]]~~	+
-	~~[[Category: Nysgrc]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 11:27, 23 March 2022

OCA — Wed, 23 Mar 2022 11:27:06 GMT

←Older revision		Revision as of 11:27, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='5iih' size='340' side='right'caption='[[5iih]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5iih' size='340' side='right'caption='[[5iih]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iih]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IIH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hoz\|5hoz]], [[3v08\|3v08]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5hoz\|5hoz]], [[3v08\|3v08]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [~~http~~://pdbe.org/5iih PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iih PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [https://pdbe.org/5iih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [https://www.ebi.ac.uk/pdbsum/5iih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:19, 3 June 2020

OCA — Wed, 03 Jun 2020 07:19:32 GMT

←Older revision		Revision as of 07:19, 3 June 2020
Line 1:		Line 1:

	==Crystal structure of Equine Serum Albumin in the presence of 2.5 mM zinc at pH 7.4==		==Crystal structure of Equine Serum Albumin in the presence of 2.5 mM zinc at pH 7.4==
-	<StructureSection load='5iih' size='340' side='right' caption='[[5iih]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5iih' size='340' side='right'caption='[[5iih]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IIH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hoz\|5hoz]], [[3v08\|3v08]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hoz\|5hoz]], [[3v08\|3v08]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [http://pdbe.org/5iih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [http://www.ebi.ac.uk/pdbsum/5iih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [http://pdbe.org/5iih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [http://www.ebi.ac.uk/pdbsum/5iih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5iih" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iih" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Albumin 3D structures\|Albumin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
		+	[[Category: Large Structures]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Cooper, D R]]		[[Category: Cooper, D R]]

OCA at 07:24, 13 December 2017

OCA — Wed, 13 Dec 2017 07:24:00 GMT

←Older revision		Revision as of 07:24, 13 December 2017
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [http://pdbe.org/5iih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [http://www.ebi.ac.uk/pdbsum/5iih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [http://pdbe.org/5iih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [http://www.ebi.ac.uk/pdbsum/5iih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Zinc is an essential nutrient in the body; it is required for the catalytic activity of many hundreds of human enzymes and virtually all biological processes, therefore its homeostasis and trafficking is of crucial interest. Serum albumin is the major carrier of Zn(2+) in the blood and is required for its systemic distribution. Here we present the first crystal structures of human serum albumin (HSA) and equine serum albumin (ESA) in complex with Zn(2+). The structures allow unambiguous identification of the major zinc binding site on these two albumins, as well as several further, weaker zinc binding sites. The major site in both HSA and ESA has tetrahedral geometry and comprises three protein ligands from the sidechains of His67, His247 and Asp249 and a water molecule. Isothermal titration calorimetric studies of a HSA H67A mutant confirm this to be the highest affinity Zn(2+) site. Furthermore, analysis of Zn(2+) binding to HSA and ESA proved the presence of secondary sites with 20-50-fold weaker affinities, which may become of importance under particular physiological conditions. Both calorimetry and crystallography suggest that ESA possesses an additional site compared to HSA, involving Glu153, His157 and His288. The His157 residue is replaced by Phe in HSA, incapable of metal coordination. Collectively, these findings are critical to our understanding of the role serum albumin plays in circulatory Zn(2+) handling and cellular delivery.
		+
		+	Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins.,Handing KB, Shabalin IG, Kassaar O, Khazaipoul S, Blindauer CA, Stewart AJ, Chruszcz M, Minor W Chem Sci. 2016 Nov 1;7(11):6635-6648. doi: 10.1039/c6sc02267g. Epub 2016 Aug 15. PMID:28567254<ref>PMID:28567254</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5iih" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:38, 15 November 2017

OCA — Wed, 15 Nov 2017 17:38:10 GMT

←Older revision		Revision as of 17:38, 15 November 2017
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hoz\|5hoz]], [[3v08\|3v08]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hoz\|5hoz]], [[3v08\|3v08]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [http://pdbe.org/5iih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [http://www.ebi.ac.uk/pdbsum/5iih PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [http://pdbe.org/5iih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [http://www.ebi.ac.uk/pdbsum/5iih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iih ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 03:53, 11 May 2016

OCA — Wed, 11 May 2016 03:53:58 GMT

←Older revision		Revision as of 03:53, 11 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5iih ~~is ON HOLD~~	+	==Crystal structure of Equine Serum Albumin in the presence of 2.5 mM zinc at pH 7.4==
-		+	<StructureSection load='5iih' size='340' side='right' caption='[[5iih]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~: ~~Handing, K~~.B.~~, Shabalin, I~~.G., ~~Cooper~~, D.R., ~~Almo, S~~.C., ~~Minor~~, W., ~~New York Structural Genomics Research Consortium (NYSGRC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5iih]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IIH FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of Equine Serum Albumin in the presence of 2~~.~~5 mM zinc at pH 7~~.4	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hoz\|5hoz]], [[3v08\|3v08]]</td></tr>
-	[[Category: Almo, S.C]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iih OCA], [http://pdbe.org/5iih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iih RCSB], [http://www.ebi.ac.uk/pdbsum/5iih PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Equus caballus]]
		+	[[Category: Almo, S C]]
		+	[[Category: Cooper, D R]]
		+	[[Category: Handing, K B]]
	[[Category: Minor, W]]		[[Category: Minor, W]]
-	[[Category: ~~Handing, K.B~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shabalin, I.G]]	+	[[Category: Shabalin, I G]]
-	[[Category: ~~New York Structural Genomics Research Consortium (~~Nysgrc)]]	+	[[Category: Nysgrc]]
-	[[Category: ~~Cooper, D.R~~]]	+	[[Category: Psi-biology]]
		+	[[Category: Transport protein]]

OCA: Protected "5iih" [edit=sysop:move=sysop]

OCA — Thu, 10 Mar 2016 02:22:43 GMT

Protected "5iih" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:22, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5iih is ON HOLD Authors: Handing, K.B., Shabalin, I.G., Cooper, D.R., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGR...

OCA — Thu, 10 Mar 2016 02:22:41 GMT

New page: '''Unreleased structure''' The entry 5iih is ON HOLD Authors: Handing, K.B., Shabalin, I.G., Cooper, D.R., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGR...

New page

'''Unreleased structure'''

The entry 5iih is ON HOLD

Authors: Handing, K.B., Shabalin, I.G., Cooper, D.R., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)

Description: Crystal structure of Equine Serum Albumin in the presence of 2.5 mM zinc at pH 7.4
[[Category: Unreleased Structures]]
[[Category: Almo, S.C]]
[[Category: Minor, W]]
[[Category: Handing, K.B]]
[[Category: Shabalin, I.G]]
[[Category: New York Structural Genomics Research Consortium (Nysgrc)]]
[[Category: Cooper, D.R]]