5ik5 - Revision history

OCA at 13:58, 30 August 2023

OCA — Wed, 30 Aug 2023 13:58:24 GMT

←Older revision		Revision as of 13:58, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='5ik5' size='340' side='right'caption='[[5ik5]], [[Resolution\|resolution]] 1.39Å' scene=''>		<StructureSection load='5ik5' size='340' side='right'caption='[[5ik5]], [[Resolution\|resolution]] 1.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ik5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IK5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IK5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ik5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IK5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4MU:7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE'>4MU</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=~~XYS~~:~~XYLOPYRANOSE~~'>~~XYS~~</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.39Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[5ik4\|5ik4]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4MU:7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE'>4MU</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">Lama2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ik5 OCA], [https://pdbe.org/5ik5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ik5 RCSB], [https://www.ebi.ac.uk/pdbsum/5ik5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ik5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ik5 OCA], [~~http~~://pdbe.org/5ik5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ik5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ik5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ik5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE]] Note=Defects in Lama2 are a cause of murine muscular dystrophy (dy2J).	+	[https://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE] Note=Defects in Lama2 are a cause of murine muscular dystrophy (dy2J).
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	+	[https://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Briggs~~, D C~~]]	+	[[Category: Briggs DC]]
-	[[Category: Campbell~~, K P~~]]	+	[[Category: Campbell KP]]
-	[[Category: Hohenester, E]]	+	[[Category: Hohenester E]]
-	~~[[Category: Extracellular matrix]]~~	+
-	~~[[Category: Lg domain]]~~	+
-	~~[[Category: Ligand binding]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 07:21, 3 June 2020

OCA — Wed, 03 Jun 2020 07:21:45 GMT

←Older revision		Revision as of 07:21, 3 June 2020
Line 1:		Line 1:

	==Laminin A2LG45 C-form, G6/7 bound.==		==Laminin A2LG45 C-form, G6/7 bound.==
-	<StructureSection load='5ik5' size='340' side='right' caption='[[5ik5]], [[Resolution\|resolution]] 1.39Å' scene=''>	+	<StructureSection load='5ik5' size='340' side='right'caption='[[5ik5]], [[Resolution\|resolution]] 1.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ik5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IK5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IK5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ik5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IK5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IK5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4MU:7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE'>4MU</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4MU:7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE'>4MU</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ik4\|5ik4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ik4\|5ik4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ik5 OCA], [http://pdbe.org/5ik5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ik5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ik5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ik5 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Lama2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ik5 OCA], [http://pdbe.org/5ik5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ik5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ik5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ik5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 5ik5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ik5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Laminin\|Laminin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Briggs, D C]]		[[Category: Briggs, D C]]
	[[Category: Campbell, K P]]		[[Category: Campbell, K P]]

OCA at 05:25, 9 September 2016

OCA — Fri, 09 Sep 2016 05:25:52 GMT

←Older revision		Revision as of 05:25, 9 September 2016
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.		[[http://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dystroglycan is a highly glycosylated extracellular matrix receptor with essential functions in skeletal muscle and the nervous system. Reduced matrix binding by alpha-dystroglycan (alpha-DG) due to perturbed glycosylation is a pathological feature of several forms of muscular dystrophy. Like-acetylglucosaminyltransferase (LARGE) synthesizes the matrix-binding heteropolysaccharide [-glucuronic acid-beta1,3-xylose-alpha1,3-]n. Using a dual exoglycosidase digestion, we confirm that this polysaccharide is present on native alpha-DG from skeletal muscle. The atomic details of matrix binding were revealed by a high-resolution crystal structure of laminin-G-like (LG) domains 4 and 5 (LG4 and LG5) of laminin-alpha2 bound to a LARGE-synthesized oligosaccharide. A single glucuronic acid-beta1,3-xylose disaccharide repeat straddles a Ca2+ ion in the LG4 domain, with oxygen atoms from both sugars replacing Ca2+-bound water molecules. The chelating binding mode accounts for the high affinity of this protein-carbohydrate interaction. These results reveal a previously uncharacterized mechanism of carbohydrate recognition and provide a structural framework for elucidating the mechanisms underlying muscular dystrophy.
		+
		+	Structural basis of laminin binding to the LARGE glycans on dystroglycan.,Briggs DC, Yoshida-Moriguchi T, Zheng T, Venzke D, Anderson ME, Strazzulli A, Moracci M, Yu L, Hohenester E, Campbell KP Nat Chem Biol. 2016 Aug 15. doi: 10.1038/nchembio.2146. PMID:27526028<ref>PMID:27526028</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ik5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:26, 10 August 2016

OCA — Wed, 10 Aug 2016 16:26:33 GMT

←Older revision		Revision as of 16:26, 10 August 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ik5 is ~~ON HOLD until Paper Publication~~	+	==Laminin A2LG45 C-form, G6/7 bound.==
-		+	<StructureSection load='5ik5' size='340' side='right' caption='[[5ik5]], [[Resolution\|resolution]] 1.39Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ik5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IK5 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4MU:7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE'>4MU</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ik4\|5ik4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ik5 OCA], [http://pdbe.org/5ik5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ik5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ik5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ik5 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE]] Note=Defects in Lama2 are a cause of murine muscular dystrophy (dy2J).
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LAMA2_MOUSE LAMA2_MOUSE]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Briggs, D C]]
		+	[[Category: Campbell, K P]]
		+	[[Category: Hohenester, E]]
		+	[[Category: Extracellular matrix]]
		+	[[Category: Lg domain]]
		+	[[Category: Ligand binding]]
		+	[[Category: Structural protein]]

OCA at 14:29, 15 May 2016

OCA — Sun, 15 May 2016 14:29:22 GMT

←Older revision		Revision as of 14:29, 15 May 2016
Line 3:		Line 3:
	The entry 5ik5 is ON HOLD until Paper Publication		The entry 5ik5 is ON HOLD until Paper Publication

-	Authors: ~~Briggs, D.C., Hohenester, E., Campbell, K.P.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Hohenester, E]]
-	[[Category: Campbell, K.P]]
-	[[Category: Briggs, D.C]]

OCA at 00:34, 11 May 2016

OCA — Wed, 11 May 2016 00:34:16 GMT

←Older revision		Revision as of 00:34, 11 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ik5 is ON HOLD	+	The entry 5ik5 is ON HOLD until Paper Publication

	Authors: Briggs, D.C., Hohenester, E., Campbell, K.P.		Authors: Briggs, D.C., Hohenester, E., Campbell, K.P.

OCA: Protected "5ik5" [edit=sysop:move=sysop]

OCA — Thu, 10 Mar 2016 02:28:51 GMT

Protected "5ik5" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:28, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5ik5 is ON HOLD Authors: Briggs, D.C., Hohenester, E., Campbell, K.P. Description: Category: Unreleased Structures Category: Hohenester, E...

OCA — Thu, 10 Mar 2016 02:28:49 GMT

New page: '''Unreleased structure''' The entry 5ik5 is ON HOLD Authors: Briggs, D.C., Hohenester, E., Campbell, K.P. Description: Category: Unreleased Structures Category: Hohenester, E...

New page

'''Unreleased structure'''

The entry 5ik5 is ON HOLD

Authors: Briggs, D.C., Hohenester, E., Campbell, K.P.

Description:
[[Category: Unreleased Structures]]
[[Category: Hohenester, E]]
[[Category: Campbell, K.P]]
[[Category: Briggs, D.C]]