5ikq - Revision history

OCA at 13:59, 30 August 2023

OCA — Wed, 30 Aug 2023 13:59:06 GMT

←Older revision		Revision as of 13:59, 30 August 2023
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	<StructureSection load='5ikq' size='340' side='right'caption='[[5ikq]], [[Resolution\|resolution]] 2.41Å' scene=''>		<StructureSection load='5ikq' size='340' side='right'caption='[[5ikq]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ikq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ikq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IKQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=JMS:2-[(2,6-DICHLORO-3-METHYL-PHENYL)AMINO]BENZOIC+ACID'>JMS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.41Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ikt\|5ikt]], [[5ikr\|5ikr]], [[5ikv\|5ikv]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=JMS:2-[(2,6-DICHLORO-3-METHYL-PHENYL)AMINO]BENZOIC+ACID'>JMS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTGS2, COX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ikq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikq OCA], [https://pdbe.org/5ikq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ikq RCSB], [https://www.ebi.ac.uk/pdbsum/5ikq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikq ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ikq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikq OCA], [~~http~~://pdbe.org/5ikq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ikq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ikq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGH2_HUMAN PGH2_HUMAN]] Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<ref>PMID:16373578</ref>	+	[https://www.uniprot.org/uniprot/PGH2_HUMAN PGH2_HUMAN] Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<ref>PMID:16373578</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Prostaglandin-endoperoxide synthase]]~~	+	[[Category: Malkowski MG]]
-	[[Category: Malkowski~~, M G~~]]	+	[[Category: Orlando BJ]]
-	[[Category: Orlando~~, B J]]~~	+
-	~~[[Category: Cox meclofenamic]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 11:49, 25 December 2019

OCA — Wed, 25 Dec 2019 11:49:40 GMT

←Older revision		Revision as of 11:49, 25 December 2019
Line 1:		Line 1:

	==The Structure of Meclofenamic Acid Bound to Human Cyclooxygenase-2==		==The Structure of Meclofenamic Acid Bound to Human Cyclooxygenase-2==
-	<StructureSection load='5ikq' size='340' side='right' caption='[[5ikq]], [[Resolution\|resolution]] 2.41Å' scene=''>	+	<StructureSection load='5ikq' size='340' side='right'caption='[[5ikq]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ikq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ikq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IKQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=JMS:2-[(2,6-DICHLORO-3-METHYL-PHENYL)AMINO]BENZOIC+ACID'>JMS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=JMS:2-[(2,6-DICHLORO-3-METHYL-PHENYL)AMINO]BENZOIC+ACID'>JMS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ikt\|5ikt]], [[5ikr\|5ikr]], [[5ikv\|5ikv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ikt\|5ikt]], [[5ikr\|5ikr]], [[5ikv\|5ikv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTGS2, COX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ikq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikq OCA], [http://pdbe.org/5ikq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ikq RCSB], [http://www.ebi.ac.uk/pdbsum/5ikq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ikq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikq OCA], [http://pdbe.org/5ikq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ikq RCSB], [http://www.ebi.ac.uk/pdbsum/5ikq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikq ProSAT]</span></td></tr>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5ikq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ikq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclooxygenase 3D structures\|Cyclooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Prostaglandin-endoperoxide synthase]]		[[Category: Prostaglandin-endoperoxide synthase]]
	[[Category: Malkowski, M G]]		[[Category: Malkowski, M G]]

OCA at 12:51, 6 November 2017

OCA — Mon, 06 Nov 2017 12:51:28 GMT

←Older revision		Revision as of 12:51, 6 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5ikq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ikq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclooxygenase\|Cyclooxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:37, 27 September 2017

OCA — Wed, 27 Sep 2017 09:37:59 GMT

←Older revision		Revision as of 09:37, 27 September 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5ikq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ikq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclooxygenase\|Cyclooxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:03, 27 July 2016

OCA — Wed, 27 Jul 2016 08:03:00 GMT

←Older revision		Revision as of 08:03, 27 July 2016
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ikt\|5ikt]], [[5ikr\|5ikr]], [[5ikv\|5ikv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ikt\|5ikt]], [[5ikr\|5ikr]], [[5ikv\|5ikv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ikq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikq OCA], [http://pdbe.org/5ikq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ikq RCSB], [http://www.ebi.ac.uk/pdbsum/5ikq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ikq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikq OCA], [http://pdbe.org/5ikq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ikq RCSB], [http://www.ebi.ac.uk/pdbsum/5ikq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:41, 20 June 2016

OCA — Mon, 20 Jun 2016 07:41:17 GMT

←Older revision		Revision as of 07:41, 20 June 2016
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PGH2_HUMAN PGH2_HUMAN]] Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<ref>PMID:16373578</ref>		[[http://www.uniprot.org/uniprot/PGH2_HUMAN PGH2_HUMAN]] Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<ref>PMID:16373578</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid (AA) and endocannabinoid substrates, placing the enzyme at a unique junction between the eicosanoid and endocannabinoid signaling pathways. COX-2 is a sequence homodimer, but the enzyme displays half-of-sites reactivity, such that only one monomer of the dimer is active at a given time. Certain rapid reversible, competitive nonsterroidal anti-inflammatory drugs (NSAIDs) have been shown to inhibit COX-2 in a substrate-selective manner, with the binding of inhibitor to a single monomer sufficient to inhibit the oxygenation of endocannabinoids, but not AA. The underlying mechanism responsible for substrate-selective inhibition has remained elusive. We utilized structural and biophysical methods to evaluate flufenamic acid, meclofenamic acid, mefenamic acid, and tolfenamic acid for their ability to act as substrate-selective inhibitors. Crystal structures of each drug in complex with human COX-2 revealed that the inhibitor binds within the cyclooxygenase channel in an inverted orientation, with the carboxylate group interacting with Tyr-385 and Ser-530 at the top of the channel. Tryptophan fluorescence quenching, continuous-wave electron spin resonance, and UV/Vis spectroscopy demonstrate that flufenamic acid, mefenamic acid, and tolfenamic acid are substrate-selective inhibitors that bind rapidly to COX-2, quench tyrosyl radicals, and reduce higher oxidation states of the heme moiety. Substrate-selective inhibition was attenuated by the addition of the lipid peroxide 15-hydroperoxyeicosatertaenoic acid. Collectively, these studies implicate peroxide tone as an important mechanistic component of substrate-selective inhibition by flufenamic acid, mefenamic acid, and tolfenamic acid.
		+
		+	Substrate Selective Inhibition of Cyclooxygenase-2 by Fenamic Acid Derivatives is Dependent on Peroxide Tone.,Orlando BJ, Malkowski MG J Biol Chem. 2016 May 20. pii: jbc.M116.725713. PMID:27226593<ref>PMID:27226593</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ikq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:00, 1 June 2016

OCA — Wed, 01 Jun 2016 23:00:38 GMT

←Older revision		Revision as of 23:00, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5ikq is ~~ON HOLD~~	+	==The Structure of Meclofenamic Acid Bound to Human Cyclooxygenase-2==
-		+	<StructureSection load='5ikq' size='340' side='right' caption='[[5ikq]], [[Resolution\|resolution]] 2.41Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ikq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IKQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=JMS:2-[(2,6-DICHLORO-3-METHYL-PHENYL)AMINO]BENZOIC+ACID'>JMS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ikt\|5ikt]], [[5ikr\|5ikr]], [[5ikv\|5ikv]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ikq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikq OCA], [http://pdbe.org/5ikq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ikq RCSB], [http://www.ebi.ac.uk/pdbsum/5ikq PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGH2_HUMAN PGH2_HUMAN]] Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<ref>PMID:16373578</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Prostaglandin-endoperoxide synthase]]
		+	[[Category: Malkowski, M G]]
		+	[[Category: Orlando, B J]]
		+	[[Category: Cox meclofenamic]]
		+	[[Category: Oxidoreductase]]

OCA at 14:30, 15 May 2016

OCA — Sun, 15 May 2016 14:30:13 GMT

←Older revision		Revision as of 14:30, 15 May 2016
Line 3:		Line 3:
	The entry 5ikq is ON HOLD		The entry 5ikq is ON HOLD

-	Authors: ~~Orlando, B.J., Malkowski, M.G.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Orlando, B.J]]
-	[[Category: Malkowski, M.G]]

OCA: Protected "5ikq" [edit=sysop:move=sysop]

OCA — Thu, 10 Mar 2016 02:30:49 GMT

Protected "5ikq" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:30, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5ikq is ON HOLD Authors: Orlando, B.J., Malkowski, M.G. Description: Category: Unreleased Structures Category: Orlando, B.J [[Category: Ma...

OCA — Thu, 10 Mar 2016 02:30:47 GMT

New page: '''Unreleased structure''' The entry 5ikq is ON HOLD Authors: Orlando, B.J., Malkowski, M.G. Description: Category: Unreleased Structures Category: Orlando, B.J [[Category: Ma...

New page

'''Unreleased structure'''

The entry 5ikq is ON HOLD

Authors: Orlando, B.J., Malkowski, M.G.

Description:
[[Category: Unreleased Structures]]
[[Category: Orlando, B.J]]
[[Category: Malkowski, M.G]]