5iqp - Revision history

OCA at 14:06, 30 August 2023

OCA — Wed, 30 Aug 2023 14:06:26 GMT

←Older revision		Revision as of 14:06, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='5iqp' size='340' side='right'caption='[[5iqp]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5iqp' size='340' side='right'caption='[[5iqp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iqp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iqp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IQP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.602Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~YWHAQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5iqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqp OCA], [~~http~~://pdbe.org/5iqp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iqp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iqp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqp OCA], [https://pdbe.org/5iqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iqp RCSB], [https://www.ebi.ac.uk/pdbsum/5iqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/1433T_HUMAN 1433T_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.<ref>PMID:12177059</ref>	+	[https://www.uniprot.org/uniprot/1433T_HUMAN 1433T_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.<ref>PMID:12177059</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gamblin~~, S J~~]]	+	[[Category: Gamblin SJ]]
-	[[Category: Smerdon~~, S J~~]]	+	[[Category: Smerdon SJ]]
-	[[Category: Xiao, B]]	+	[[Category: Xiao B]]
-	~~[[Category: Binding to kinase]]~~	+
-	~~[[Category: Multiple signalling pathway]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:28, 3 June 2020

OCA — Wed, 03 Jun 2020 07:28:13 GMT

←Older revision		Revision as of 07:28, 3 June 2020
Line 1:		Line 1:

	==14-3-3 PROTEIN TAU ISOFORM==		==14-3-3 PROTEIN TAU ISOFORM==
-	<StructureSection load='5iqp' size='340' side='right' caption='[[5iqp]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5iqp' size='340' side='right'caption='[[5iqp]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iqp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iqp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IQP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqp OCA], [http://pdbe.org/5iqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqp RCSB], [http://www.ebi.ac.uk/pdbsum/5iqp PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YWHAQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqp OCA], [http://pdbe.org/5iqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqp RCSB], [http://www.ebi.ac.uk/pdbsum/5iqp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5iqp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iqp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]
	[[Category: Smerdon, S J]]		[[Category: Smerdon, S J]]

OCA: Protected "5iqp" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 13:08:31 GMT

Protected "5iqp" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:08, 11 May 2016

OCA: New page: ==14-3-3 PROTEIN TAU ISOFORM== == Structural highlights ==
OCA — Wed, 11 May 2016 13:08:26 GMT

New page: ==14-3-3 PROTEIN TAU ISOFORM== <StructureSection load='5iqp' size='340' side='right' caption='5iqp, resolution 2.60Å' scene=''> == Structural highlights == <table...

New page

==14-3-3 PROTEIN TAU ISOFORM==
<StructureSection load='5iqp' size='340' side='right' caption='[[5iqp]], [[Resolution|resolution]] 2.60Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5iqp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IQP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqp OCA], [http://pdbe.org/5iqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqp RCSB], [http://www.ebi.ac.uk/pdbsum/5iqp PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/1433T_HUMAN 1433T_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.<ref>PMID:12177059</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A broad range of organisms and tissues contain 14-3-3 proteins, which have been associated with many diverse functions including critical roles in signal transduction pathways, exocytosis and cell cycle regulation. We report here the crystal structure of the human T-cell 14-3-3 isoform (tau) dimer at 2.6 A resolution. Each monomer (Mr 28K) is composed of an unusual arrangement of nine antiparallel alpha-helices organized as two structural domains. The dimer creates a large, negatively charged channel approximately 35 A broad, 35 A wide and 20 A deep. Overall, invariant residues line the interior of this channel whereas the more variable residues are distributed on the outer surface. At the base of this channel is a 16-residue segment of 14-3-3 which has been implicated in the binding of 14-3-3 to protein kinase C.

Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways.,Xiao B, Smerdon SJ, Jones DH, Dodson GG, Soneji Y, Aitken A, Gamblin SJ Nature. 1995 Jul 13;376(6536):188-91. PMID:7603573<ref>PMID:7603573</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5iqp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Gamblin, S J]]
[[Category: Smerdon, S J]]
[[Category: Xiao, B]]
[[Category: Binding to kinase]]
[[Category: Multiple signalling pathway]]
[[Category: Phosphorylation]]
[[Category: Signaling protein]]