5iqs - Revision history

OCA at 12:52, 17 January 2024

OCA — Wed, 17 Jan 2024 12:52:09 GMT

←Older revision		Revision as of 12:52, 17 January 2024
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	<StructureSection load='5iqs' size='340' side='right'caption='[[5iqs]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5iqs' size='340' side='right'caption='[[5iqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iqs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hapalosiphon_welwitschii_utex_1830~~ Hapalosiphon welwitschii ~~utex~~ 1830]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iqs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hapalosiphon_welwitschii_UTEX_B_1830 Hapalosiphon welwitschii UTEX B 1830]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IQS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5iqt\|5iqt]], [[5iqu\|5iqu]], [[5iqv\|5iqv]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [https://pdbe.org/5iqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [https://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [https://pdbe.org/5iqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [https://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A067YX61_9CYAN A0A067YX61_9CYAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hapalosiphon welwitschii ~~utex~~ 1830]]	+	[[Category: Hapalosiphon welwitschii UTEX B 1830]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ananth, N]]	+	[[Category: Ananth N]]
-	[[Category: Boal~~, A K~~]]	+	[[Category: Boal AK]]
-	[[Category: Mitchell~~, A J]]~~	+	[[Category: Mitchell AJ]]
-	~~[[Category: Metalloenzyme halogenase 2-oxoglutarate]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:10, 13 April 2022

OCA — Wed, 13 Apr 2022 10:10:52 GMT

←Older revision		Revision as of 10:10, 13 April 2022
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	<StructureSection load='5iqs' size='340' side='right'caption='[[5iqs]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5iqs' size='340' side='right'caption='[[5iqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iqs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iqs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hapalosiphon_welwitschii_utex_1830 Hapalosiphon welwitschii utex 1830]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IQS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iqt\|5iqt]], [[5iqu\|5iqu]], [[5iqv\|5iqv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5iqt\|5iqt]], [[5iqu\|5iqu]], [[5iqv\|5iqv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [~~http~~://pdbe.org/5iqs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [https://pdbe.org/5iqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [https://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hapalosiphon welwitschii utex 1830]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ananth, N]]		[[Category: Ananth, N]]

OCA at 07:28, 3 June 2020

OCA — Wed, 03 Jun 2020 07:28:16 GMT

←Older revision		Revision as of 07:28, 3 June 2020
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	==WelO5 bound to Fe(II), Cl, and 2-oxoglutarate==		==WelO5 bound to Fe(II), Cl, and 2-oxoglutarate==
-	<StructureSection load='5iqs' size='340' side='right' caption='[[5iqs]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5iqs' size='340' side='right'caption='[[5iqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iqs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IQS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iqs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IQS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iqt\|5iqt]], [[5iqu\|5iqu]], [[5iqv\|5iqv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iqt\|5iqt]], [[5iqu\|5iqu]], [[5iqv\|5iqv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [http://pdbe.org/5iqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [http://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [http://pdbe.org/5iqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [http://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ananth, N]]		[[Category: Ananth, N]]
	[[Category: Boal, A K]]		[[Category: Boal, A K]]

OCA at 10:25, 13 July 2016

OCA — Wed, 13 Jul 2016 10:25:26 GMT

←Older revision		Revision as of 10:25, 13 July 2016
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [http://pdbe.org/5iqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [http://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [http://pdbe.org/5iqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [http://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A 2.4-A-resolution X-ray crystal structure of the carrier-protein-independent halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-oxo-iron(IV) (haloferryl) intermediate. Prior study of related halogenases forecasts substrate hydroxylation in this active-site configuration, but X-ray crystallographic verification of C13 halogenation in single crystals mandates that ligand dynamics must reposition the oxygen ligand to enable the observed outcome. S189A WelO5 produces a mixture of halogenation and hydroxylation products, showing that an outer-sphere hydrogen-bonding group orchestrates ligand movements to achieve a configuration that promotes halogen transfer.
		+
		+	Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.,Mitchell AJ, Zhu Q, Maggiolo AO, Ananth NR, Hillwig ML, Liu X, Boal AK Nat Chem Biol. 2016 Jun 27. doi: 10.1038/nchembio.2112. PMID:27348090<ref>PMID:27348090</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5iqs" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 02:57, 13 July 2016

OCA — Wed, 13 Jul 2016 02:57:30 GMT

←Older revision		Revision as of 02:57, 13 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5iqs is ~~ON HOLD until Paper Publication~~	+	==WelO5 bound to Fe(II), Cl, and 2-oxoglutarate==
-		+	<StructureSection load='5iqs' size='340' side='right' caption='[[5iqs]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5iqs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IQS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iqt\|5iqt]], [[5iqu\|5iqu]], [[5iqv\|5iqv]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqs OCA], [http://pdbe.org/5iqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqs RCSB], [http://www.ebi.ac.uk/pdbsum/5iqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqs ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ananth, N]]
		+	[[Category: Boal, A K]]
		+	[[Category: Mitchell, A J]]
		+	[[Category: Metalloenzyme halogenase 2-oxoglutarate]]
		+	[[Category: Oxidoreductase]]

OCA at 14:39, 15 May 2016

OCA — Sun, 15 May 2016 14:39:10 GMT

←Older revision		Revision as of 14:39, 15 May 2016
Line 3:		Line 3:
	The entry 5iqs is ON HOLD until Paper Publication		The entry 5iqs is ON HOLD until Paper Publication

-	Authors: ~~Mitchell, A.J., Ananth, N., Boal, A.K.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Boal, A.K]]
-	[[Category: Ananth, N]]
-	[[Category: Mitchell, A.J]]

OCA: Protected "5iqs" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 00:48:12 GMT

Protected "5iqs" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:48, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5iqs is ON HOLD until Paper Publication Authors: Mitchell, A.J., Ananth, N., Boal, A.K. Description: Category: Unreleased Structures [[Categor...

OCA — Wed, 11 May 2016 00:48:11 GMT

New page: '''Unreleased structure''' The entry 5iqs is ON HOLD until Paper Publication Authors: Mitchell, A.J., Ananth, N., Boal, A.K. Description: Category: Unreleased Structures [[Categor...

New page

'''Unreleased structure'''

The entry 5iqs is ON HOLD until Paper Publication

Authors: Mitchell, A.J., Ananth, N., Boal, A.K.

Description:
[[Category: Unreleased Structures]]
[[Category: Boal, A.K]]
[[Category: Ananth, N]]
[[Category: Mitchell, A.J]]