5iqz - Revision history

OCA at 14:06, 30 August 2023

OCA — Wed, 30 Aug 2023 14:06:35 GMT

←Older revision		Revision as of 14:06, 30 August 2023
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	<StructureSection load='5iqz' size='340' side='right'caption='[[5iqz]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='5iqz' size='340' side='right'caption='[[5iqz]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iqz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iqz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IQZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MAL:MALTOSE'>MAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.334Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~sirt7 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5iqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqz OCA], [~~http~~://pdbe.org/5iqz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iqz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iqz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqz OCA], [https://pdbe.org/5iqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iqz RCSB], [https://www.ebi.ac.uk/pdbsum/5iqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/SIR7_HUMAN SIR7_HUMAN] NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.<ref>PMID:16618798</ref> <ref>PMID:19174463</ref> <ref>PMID:22722849</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Priyanka, A]]	+	[[Category: Priyanka A]]
-	[[Category: Thakur~~, K G]]~~	+	[[Category: Thakur KG]]
-	~~[[Category: Alpha histone deacetylase sirtuin]]~~	+
-	~~[[Category: Fusion protein]]~~	+
-	~~[[Category: Maltose binding]]~~	+
-	~~[[Category: Sirt7]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 07:28, 3 June 2020

OCA — Wed, 03 Jun 2020 07:28:31 GMT

←Older revision		Revision as of 07:28, 3 June 2020
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	==Crystal structure of N-terminal domain of Human SIRT7==		==Crystal structure of N-terminal domain of Human SIRT7==
-	<StructureSection load='5iqz' size='340' side='right' caption='[[5iqz]], [[Resolution\|resolution]] 2.33Å' scene=''>	+	<StructureSection load='5iqz' size='340' side='right'caption='[[5iqz]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iqz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IQZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqz OCA], [http://pdbe.org/5iqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqz RCSB], [http://www.ebi.ac.uk/pdbsum/5iqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqz ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sirt7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqz OCA], [http://pdbe.org/5iqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqz RCSB], [http://www.ebi.ac.uk/pdbsum/5iqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5iqz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iqz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone deacetylase 3D structures\|Histone deacetylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Priyanka, A]]		[[Category: Priyanka, A]]
	[[Category: Thakur, K G]]		[[Category: Thakur, K G]]

OCA at 15:44, 27 July 2016

OCA — Wed, 27 Jul 2016 15:44:06 GMT

←Older revision		Revision as of 15:44, 27 July 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5iqz is ~~ON HOLD~~	+	==Crystal structure of N-terminal domain of Human SIRT7==
		+	<StructureSection load='5iqz' size='340' side='right' caption='[[5iqz]], [[Resolution\|resolution]] 2.33Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5iqz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IQZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqz OCA], [http://pdbe.org/5iqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqz RCSB], [http://www.ebi.ac.uk/pdbsum/5iqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqz ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human SIRT7 is an NAD+ dependent deacetylase which belongs to sirtuin family of proteins. SIRT7, like other sirtuins has conserved catalytic domain and is flanked by N- and C- terminal domains reported to play vital functional roles. Here, we report the crystal structure of the N-terminal domain of human SIRT7 (SIRT7NTD ) at 2.3 A resolution as MBP-SIRT7NTD fusion protein. SIRT7NTD adopts three-helical domain architecture and comparative structural analyses suggest similarities to some DNA binding motifs and transcription regulators. We also report here the importance of N- and C-terminal domains in soluble expression of SIRT7. This article is protected by copyright. All rights reserved.

-	~~Authors~~:	+	Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture.,Priyanka A, Solanki V, Parkesh R, Thakur KG Proteins. 2016 Jun 10. doi: 10.1002/prot.25085. PMID:27287224<ref>PMID:27287224</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5iqz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Priyanka, A]]
		+	[[Category: Thakur, K G]]
		+	[[Category: Alpha histone deacetylase sirtuin]]
		+	[[Category: Fusion protein]]
		+	[[Category: Maltose binding]]
		+	[[Category: Sirt7]]
		+	[[Category: Sugar binding protein]]

OCA at 14:39, 15 May 2016

OCA — Sun, 15 May 2016 14:39:23 GMT

←Older revision		Revision as of 14:39, 15 May 2016
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	The entry 5iqz is ON HOLD		The entry 5iqz is ON HOLD

-	Authors: ~~Thakur, K.G., Priyanka, A.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Priyanka, A]]
-	[[Category: Thakur, K.G]]

OCA: Protected "5iqz" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 00:48:34 GMT

Protected "5iqz" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:48, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5iqz is ON HOLD Authors: Thakur, K.G., Priyanka, A. Description: Category: Unreleased Structures Category: Priyanka, A [[Category: Thakur,...

OCA — Wed, 11 May 2016 00:48:33 GMT

New page: '''Unreleased structure''' The entry 5iqz is ON HOLD Authors: Thakur, K.G., Priyanka, A. Description: Category: Unreleased Structures Category: Priyanka, A [[Category: Thakur,...

New page

'''Unreleased structure'''

The entry 5iqz is ON HOLD

Authors: Thakur, K.G., Priyanka, A.

Description:
[[Category: Unreleased Structures]]
[[Category: Priyanka, A]]
[[Category: Thakur, K.G]]