5iuv - Revision history

OCA at 10:32, 6 September 2023

OCA — Wed, 06 Sep 2023 10:32:39 GMT

←Older revision		Revision as of 10:32, 6 September 2023
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	<StructureSection load='5iuv' size='340' side='right'caption='[[5iuv]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='5iuv' size='340' side='right'caption='[[5iuv]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iuv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Psesm Psesm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IUV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iuv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato_str._DC3000 Pseudomonas syringae pv. tomato str. DC3000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IUV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.928Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iuu\|5iuu]]~~, [[~~5iuw~~\|~~5iuw~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PSPTO_0092 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=223283 PSESM])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iuv OCA], [https://pdbe.org/5iuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iuv RCSB], [https://www.ebi.ac.uk/pdbsum/5iuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iuv ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iuv OCA], [~~http~~://pdbe.org/5iuv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iuv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iuv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iuv ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q88BC5_PSESM Q88BC5_PSESM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Psesm~~]]	+	[[Category: Pseudomonas syringae pv. tomato str. DC3000]]
-	[[Category: Jez~~, J M~~]]	+	[[Category: Jez JM]]
-	[[Category: Kunkel, B]]	+	[[Category: Kunkel B]]
-	[[Category: Lee~~, S G~~]]	+	[[Category: Lee SG]]
-	[[Category: McClerklin, S]]	+	[[Category: McClerklin S]]
-	~~[[Category: Aldehyde dehydrogenase]]~~	+
-	~~[[Category: Indole-3-acetaldehyde dehydrogenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:38, 27 November 2019

OCA — Wed, 27 Nov 2019 07:38:26 GMT

←Older revision		Revision as of 07:38, 27 November 2019
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	==Crystal Structure of Indole-3-acetaldehyde Dehydrogenase in complexed with NAD+==		==Crystal Structure of Indole-3-acetaldehyde Dehydrogenase in complexed with NAD+==
-	<StructureSection load='5iuv' size='340' side='right' caption='[[5iuv]], [[Resolution\|resolution]] 1.93Å' scene=''>	+	<StructureSection load='5iuv' size='340' side='right'caption='[[5iuv]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5iuv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Psesm Psesm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUV FirstGlance]. <br>		<table><tr><td colspan='2'>[[5iuv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Psesm Psesm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUV FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5iuv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iuv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Psesm]]		[[Category: Psesm]]
	[[Category: Jez, J M]]		[[Category: Jez, J M]]

OCA at 06:38, 7 February 2018

OCA — Wed, 07 Feb 2018 06:38:30 GMT

←Older revision		Revision as of 06:38, 7 February 2018
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	<StructureSection load='5iuv' size='340' side='right' caption='[[5iuv]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='5iuv' size='340' side='right' caption='[[5iuv]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iuv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iuv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Psesm Psesm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iuu\|5iuu]], [[5iuw\|5iuw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iuu\|5iuu]], [[5iuw\|5iuw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSPTO_0092 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223283 PSESM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iuv OCA], [http://pdbe.org/5iuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iuv RCSB], [http://www.ebi.ac.uk/pdbsum/5iuv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iuv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iuv OCA], [http://pdbe.org/5iuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iuv RCSB], [http://www.ebi.ac.uk/pdbsum/5iuv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iuv ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial pathogen Pseudomonas syringae modulates plant hormone signaling to promote infection and disease development. P. syringae uses several strategies to manipulate auxin physiology in Arabidopsis thaliana to promote pathogenesis, including its synthesis of indole-3-acetic acid (IAA), the predominant form of auxin in plants, and production of virulence factors that alter auxin responses in the host; however, the role of pathogen-derived auxin in P. syringae pathogenesis is not well understood. Here we demonstrate that P. syringae strain DC3000 produces IAA via a previously uncharacterized pathway and identify a novel indole-3-acetaldehyde dehydrogenase, AldA, that functions in IAA biosynthesis by catalyzing the NAD-dependent formation of IAA from indole-3-acetaldehyde (IAAld). Biochemical analysis and solving of the 1.9 A resolution x-ray crystal structure reveal key features of AldA for IAA synthesis, including the molecular basis of substrate specificity. Disruption of aldA and a close homolog, aldB, lead to reduced IAA production in culture and reduced virulence on A. thaliana. We use these mutants to explore the mechanism by which pathogen-derived auxin contributes to virulence and show that IAA produced by DC3000 suppresses salicylic acid-mediated defenses in A. thaliana. Thus, auxin is a DC3000 virulence factor that promotes pathogenicity by suppressing host defenses.
		+
		+	Indole-3-acetaldehyde dehydrogenase-dependent auxin synthesis contributes to virulence of Pseudomonas syringae strain DC3000.,McClerklin SA, Lee SG, Harper CP, Nwumeh R, Jez JM, Kunkel BN PLoS Pathog. 2018 Jan 2;14(1):e1006811. doi: 10.1371/journal.ppat.1006811., eCollection 2018 Jan. PMID:29293681<ref>PMID:29293681</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5iuv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Psesm]]
	[[Category: Jez, J M]]		[[Category: Jez, J M]]
	[[Category: Kunkel, B]]		[[Category: Kunkel, B]]

OCA at 07:10, 25 October 2017

OCA — Wed, 25 Oct 2017 07:10:21 GMT

←Older revision		Revision as of 07:10, 25 October 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5iuv is ~~ON HOLD until Oct 25 2018~~	+	==Crystal Structure of Indole-3-acetaldehyde Dehydrogenase in complexed with NAD+==
-		+	<StructureSection load='5iuv' size='340' side='right' caption='[[5iuv]], [[Resolution\|resolution]] 1.93Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5iuv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iuu\|5iuu]], [[5iuw\|5iuw]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iuv OCA], [http://pdbe.org/5iuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iuv RCSB], [http://www.ebi.ac.uk/pdbsum/5iuv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iuv ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jez, J M]]
		+	[[Category: Kunkel, B]]
		+	[[Category: Lee, S G]]
		+	[[Category: McClerklin, S]]
		+	[[Category: Aldehyde dehydrogenase]]
		+	[[Category: Indole-3-acetaldehyde dehydrogenase]]
		+	[[Category: Oxidoreductase]]

OCA at 05:18, 11 October 2017

OCA — Wed, 11 Oct 2017 05:18:24 GMT

←Older revision		Revision as of 05:18, 11 October 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5iuv is ON HOLD until Oct 04 2018	+	The entry 5iuv is ON HOLD until Oct 25 2018

	Authors:		Authors:

OCA at 10:44, 27 September 2017

OCA — Wed, 27 Sep 2017 10:44:54 GMT

←Older revision		Revision as of 10:44, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5iuv is ON HOLD until ~~Sep 20~~ 2018	+	The entry 5iuv is ON HOLD until Oct 04 2018

	Authors:		Authors:

OCA at 10:29, 18 January 2017

OCA — Wed, 18 Jan 2017 10:29:06 GMT

←Older revision		Revision as of 10:29, 18 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5iuv is ON HOLD until ~~Mar 18~~ 2018	+	The entry 5iuv is ON HOLD until Sep 20 2018

	Authors:		Authors:

OCA at 14:46, 15 May 2016

OCA — Sun, 15 May 2016 14:46:07 GMT

←Older revision		Revision as of 14:46, 15 May 2016
Line 3:		Line 3:
	The entry 5iuv is ON HOLD until Mar 18 2018		The entry 5iuv is ON HOLD until Mar 18 2018

-	Authors: ~~Lee, S.G, McClerklin, S., Kunkel, B., Jez, J.M.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Kunkel, B]]
-	[[Category: Jez, J.M]]
-	[[Category: Lee, S.G, Mcclerklin, S]]

OCA: Protected "5iuv" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 00:59:45 GMT

Protected "5iuv" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:59, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5iuv is ON HOLD until Mar 18 2018 Authors: Lee, S.G, McClerklin, S., Kunkel, B., Jez, J.M. Description: Category: Unreleased Structures [[Cate...

OCA — Wed, 11 May 2016 00:59:43 GMT

New page: '''Unreleased structure''' The entry 5iuv is ON HOLD until Mar 18 2018 Authors: Lee, S.G, McClerklin, S., Kunkel, B., Jez, J.M. Description: Category: Unreleased Structures [[Cate...

New page

'''Unreleased structure'''

The entry 5iuv is ON HOLD until Mar 18 2018

Authors: Lee, S.G, McClerklin, S., Kunkel, B., Jez, J.M.

Description:
[[Category: Unreleased Structures]]
[[Category: Kunkel, B]]
[[Category: Jez, J.M]]
[[Category: Lee, S.G, Mcclerklin, S]]