5iv8 - Revision history

OCA at 10:33, 6 September 2023

OCA — Wed, 06 Sep 2023 10:33:08 GMT

←Older revision		Revision as of 10:33, 6 September 2023
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	<StructureSection load='5iv8' size='340' side='right'caption='[[5iv8]], [[Resolution\|resolution]] 2.94Å' scene=''>		<StructureSection load='5iv8' size='340' side='right'caption='[[5iv8]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iv8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus~~ pneumoniae~~" (schroeter 1886) flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IV8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IV8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iv8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IV8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.938Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iva\|5iva]]~~, [[~~5iv9~~\|~~5iv9~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>AU361_02400 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~573~~ "~~Bacillus pneumoniae~~" ~~(Schroeter 1886) Flugge 1886]), lptE, APU20_03225, SM74_00486, SM87_01358 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=573 "Bacillus pneumoniae"~~ (~~Schroeter 1886~~) ~~Flugge 1886]~~)</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv8 OCA], [https://pdbe.org/5iv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iv8 RCSB], [https://www.ebi.ac.uk/pdbsum/5iv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iv8 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5iv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv8 OCA], [~~http~~://pdbe.org/5iv8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iv8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iv8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iv8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~A0A0J4W1Y0_KLEPN A0A0J4W1Y0_KLEPN]~~] Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.[HAMAP-Rule:MF_01186~~][SAAS:SAAS00074338~~]	+	[https://www.uniprot.org/uniprot/A0A0J4W1Y0_KLEVA A0A0J4W1Y0_KLEVA] Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.[HAMAP-Rule:MF_01186]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Botos, I]]	+	[[Category: Botos I]]
-	[[Category: Buchanan~~, S K~~]]	+	[[Category: Buchanan SK]]
-	[[Category: McCarthy~~, J G]]~~	+	[[Category: McCarthy JG]]
-	~~[[Category: Lipopolysaccharide]]~~	+
-	~~[[Category: Lptd]]~~	+
-	~~[[Category: Lpte]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Transporter~~]]	+

OCA at 07:33, 3 June 2020

OCA — Wed, 03 Jun 2020 07:33:04 GMT

←Older revision		Revision as of 07:33, 3 June 2020
Line 1:		Line 1:

	==The LPS Transporter LptDE from Klebsiella pneumoniae, core complex==		==The LPS Transporter LptDE from Klebsiella pneumoniae, core complex==
-	<StructureSection load='5iv8' size='340' side='right' caption='[[5iv8]], [[Resolution\|resolution]] 2.94Å' scene=''>	+	<StructureSection load='5iv8' size='340' side='right'caption='[[5iv8]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iv8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IV8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IV8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iv8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IV8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IV8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iva\|5iva]], [[5iv9\|5iv9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iva\|5iva]], [[5iv9\|5iv9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv8 OCA], [http://pdbe.org/5iv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iv8 RCSB], [http://www.ebi.ac.uk/pdbsum/5iv8 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AU361_02400 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886]), lptE, APU20_03225, SM74_00486, SM87_01358 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv8 OCA], [http://pdbe.org/5iv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iv8 RCSB], [http://www.ebi.ac.uk/pdbsum/5iv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iv8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Botos, I]]		[[Category: Botos, I]]
	[[Category: Buchanan, S K]]		[[Category: Buchanan, S K]]

OCA at 08:04, 1 June 2016

OCA — Wed, 01 Jun 2016 08:04:38 GMT

←Older revision		Revision as of 08:04, 1 June 2016
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-	'''Unreleased structure'''

-	The ~~entry~~ 5iv8 is ~~ON HOLD until Paper~~ Publication	+	==The LPS Transporter LptDE from Klebsiella pneumoniae, core complex==
		+	<StructureSection load='5iv8' size='340' side='right' caption='[[5iv8]], [[Resolution\|resolution]] 2.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5iv8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IV8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iva\|5iva]], [[5iv9\|5iv9]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iv8 OCA], [http://pdbe.org/5iv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iv8 RCSB], [http://www.ebi.ac.uk/pdbsum/5iv8 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A0J4W1Y0_KLEPN A0A0J4W1Y0_KLEPN]] Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.[HAMAP-Rule:MF_01186][SAAS:SAAS00074338]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Incorporation of lipopolysaccharide (LPS) into the outer membrane of Gram-negative bacteria is essential for viability, and is accomplished by a two-protein complex called LptDE. We solved crystal structures of the core LptDE complexes from Yersinia pestis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and a full-length structure of the K. pneumoniae LptDE complex. Our structures adopt the same plug and 26-strand beta-barrel architecture found recently for the Shigella flexneri and Salmonella typhimurium LptDE structures, illustrating a conserved fold across the family. A comparison of the only two full-length structures, SfLptDE and our KpLptDE, reveals a 21 degrees rotation of the LptD N-terminal domain that may impart flexibility on the trans-envelope LptCAD scaffold. Utilizing mutagenesis coupled to an in vivo functional assay and molecular dynamics simulations, we demonstrate the critical role of Pro231 and Pro246 in the function of the LptD lateral gate that allows partitioning of LPS into the outer membrane.

-	~~Authors: Botos~~, I., McCarthy, J.G., ~~Buchanan, S~~.K.	+	Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens.,Botos I, Majdalani N, Mayclin SJ, McCarthy JG, Lundquist K, Wojtowicz D, Barnard TJ, Gumbart JC, Buchanan SK Structure. 2016 May 3. pii: S0969-2126(16)30043-0. doi:, 10.1016/j.str.2016.03.026. PMID:27161977<ref>PMID:27161977</ref>

-	~~Description: The LPS Transporter LptDE from Klebsiella pneumoniae~~, ~~core complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Buchanan, S.K]]~~	+	<div class="pdbe-citations 5iv8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Botos, I]]		[[Category: Botos, I]]
-	[[Category: ~~Mccarthy~~, J.G]]	+	[[Category: Buchanan, S K]]
		+	[[Category: McCarthy, J G]]
		+	[[Category: Lipopolysaccharide]]
		+	[[Category: Lptd]]
		+	[[Category: Lpte]]
		+	[[Category: Transport protein]]
		+	[[Category: Transporter]]

OCA: Protected "5iv8" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:00:57 GMT

Protected "5iv8" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:00, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5iv8 is ON HOLD until Paper Publication Authors: Botos, I., McCarthy, J.G., Buchanan, S.K. Description: The LPS Transporter LptDE from Klebsiella p...

OCA — Wed, 11 May 2016 01:00:55 GMT

New page: '''Unreleased structure''' The entry 5iv8 is ON HOLD until Paper Publication Authors: Botos, I., McCarthy, J.G., Buchanan, S.K. Description: The LPS Transporter LptDE from Klebsiella p...

New page

'''Unreleased structure'''

The entry 5iv8 is ON HOLD until Paper Publication

Authors: Botos, I., McCarthy, J.G., Buchanan, S.K.

Description: The LPS Transporter LptDE from Klebsiella pneumoniae, core complex
[[Category: Unreleased Structures]]
[[Category: Buchanan, S.K]]
[[Category: Botos, I]]
[[Category: Mccarthy, J.G]]