5ivk - Revision history

OCA at 10:33, 6 September 2023

OCA — Wed, 06 Sep 2023 10:33:27 GMT

←Older revision		Revision as of 10:33, 6 September 2023
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	<StructureSection load='5ivk' size='340' side='right'caption='[[5ivk]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='5ivk' size='340' side='right'caption='[[5ivk]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ivk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Australian_sheep_blowfly Australian sheep blowfly~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IVK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ivk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lucilia_cuprina Lucilia cuprina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IVK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.53Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5ivh\|5ivh]], [[5ivi\|5ivi]], [[5ivd\|5ivd]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">LcaE7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7375 Australian sheep blowfly])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivk OCA], [https://pdbe.org/5ivk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ivk RCSB], [https://www.ebi.ac.uk/pdbsum/5ivk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivk OCA], [~~http~~://pdbe.org/5ivk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ivk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ivk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivk ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q25252_LUCCU Q25252_LUCCU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Australian sheep blowfly]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Correy, G J~~]]	+	[[Category: Lucilia cuprina]]
-	[[Category: ~~Jackson, C J~~]]	+	[[Category: Correy GJ]]
-	[[Category: ~~Acetylcholinesterase]]~~	+	[[Category: Jackson CJ]]
-	~~[[Category: Carboxylesterase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Organophosphate]]~~	+
-	~~[[Category: Protein dynamic~~]]	+

OCA at 07:19, 10 June 2020

OCA — Wed, 10 Jun 2020 07:19:22 GMT

←Older revision		Revision as of 07:19, 10 June 2020
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-	~~{{Large structure}}~~	+
	==The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: phosphorylated-enzyme ensemble refinement==		==The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: phosphorylated-enzyme ensemble refinement==
-	<StructureSection load='5ivk' size='340' side='right' caption='[[5ivk]], [[Resolution\|resolution]] 1.53Å' scene=''>	+	<StructureSection load='5ivk' size='340' side='right'caption='[[5ivk]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ivk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IVK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ivk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Australian_sheep_blowfly Australian sheep blowfly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IVK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivh\|5ivh]], [[5ivi\|5ivi]], [[5ivd\|5ivd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivh\|5ivh]], [[5ivi\|5ivi]], [[5ivd\|5ivd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivk OCA], [http://pdbe.org/5ivk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivk RCSB], [http://www.ebi.ac.uk/pdbsum/5ivk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivk ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LcaE7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7375 Australian sheep blowfly])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivk OCA], [http://pdbe.org/5ivk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivk RCSB], [http://www.ebi.ac.uk/pdbsum/5ivk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivk ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5ivk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ivk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carboxylesterase 3D structures\|Carboxylesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Australian sheep blowfly]]
		+	[[Category: Large Structures]]
	[[Category: Correy, G J]]		[[Category: Correy, G J]]
	[[Category: Jackson, C J]]		[[Category: Jackson, C J]]

OCA at 02:27, 13 July 2016

OCA — Wed, 13 Jul 2016 02:27:53 GMT

←Older revision		Revision as of 02:27, 13 July 2016
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivh\|5ivh]], [[5ivi\|5ivi]], [[5ivd\|5ivd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivh\|5ivh]], [[5ivi\|5ivi]], [[5ivd\|5ivd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivk OCA], [http://pdbe.org/5ivk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivk RCSB], [http://www.ebi.ac.uk/pdbsum/5ivk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivk OCA], [http://pdbe.org/5ivk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivk RCSB], [http://www.ebi.ac.uk/pdbsum/5ivk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivk ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}

OCA at 23:11, 23 June 2016

OCA — Thu, 23 Jun 2016 23:11:17 GMT

←Older revision		Revision as of 23:11, 23 June 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	{{Large structure}}
		+	==The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: phosphorylated-enzyme ensemble refinement==
		+	<StructureSection load='5ivk' size='340' side='right' caption='[[5ivk]], [[Resolution\|resolution]] 1.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ivk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IVK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPF:DIETHYL+HYDROGEN+PHOSPHATE'>DPF</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivh\|5ivh]], [[5ivi\|5ivi]], [[5ivd\|5ivd]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ivk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivk OCA], [http://pdbe.org/5ivk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivk RCSB], [http://www.ebi.ac.uk/pdbsum/5ivk PDBsum]</span></td></tr>
		+	</table>
		+	{{Large structure}}
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The proper function of enzymes often depends upon their efficient interconversion between particular conformational sub-states on a free-energy landscape. Experimentally characterizing these sub-states is challenging, which has limited our understanding of the role of protein dynamics in many enzymes. Here, we have used a combination of kinetic crystallography and detailed analysis of crystallographic protein ensembles to map the accessible conformational landscape of an insect carboxylesterase (LcalphaE7) as it traverses all steps in its catalytic cycle. LcalphaE7 is of special interest because of its evolving role in organophosphate insecticide resistance. Our results reveal that a dynamically coupled network of residues extends from the substrate-binding site to a surface loop. Interestingly, the coupling of this network that is apparent in the apoenzyme appears to be reduced in the phosphorylated enzyme intermediate. Altogether, the results of this work highlight the importance of protein dynamics to enzyme function and the evolution of new activity.

-	~~The entry 5ivk is ON HOLD~~	+	Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography.,Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ Structure. 2016 Jun 7;24(6):977-87. doi: 10.1016/j.str.2016.04.009. Epub 2016 May, 19. PMID:27210287<ref>PMID:27210287</ref>

-	~~Authors: Correy~~, G.J.~~, Jackson, C.J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: The alpha~~-~~esterase~~-~~7 carboxylesterase, E3, from the blowfly Lucilia cuprina~~: ~~phosphorylated-enzyme ensemble refinement~~	+	<div class="pdbe-citations 5ivk" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: Jackson, C.J]]	+	<references/>
-	[[Category: ~~Correy, G.J~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Correy, G J]]
		+	[[Category: Jackson, C J]]
		+	[[Category: Acetylcholinesterase]]
		+	[[Category: Carboxylesterase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Organophosphate]]
		+	[[Category: Protein dynamic]]

OCA at 12:53, 1 June 2016

OCA — Wed, 01 Jun 2016 12:53:40 GMT

←Older revision		Revision as of 12:53, 1 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ivk is ON HOLD ~~until Paper Publication~~	+	The entry 5ivk is ON HOLD

	Authors: Correy, G.J., Jackson, C.J.		Authors: Correy, G.J., Jackson, C.J.

OCA: Protected "5ivk" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:01:38 GMT

Protected "5ivk" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:01, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5ivk is ON HOLD until Paper Publication Authors: Correy, G.J., Jackson, C.J. Description: The alpha-esterase-7 carboxylesterase, E3, from the blowf...

OCA — Wed, 11 May 2016 01:01:37 GMT

New page: '''Unreleased structure''' The entry 5ivk is ON HOLD until Paper Publication Authors: Correy, G.J., Jackson, C.J. Description: The alpha-esterase-7 carboxylesterase, E3, from the blowf...

New page

'''Unreleased structure'''

The entry 5ivk is ON HOLD until Paper Publication

Authors: Correy, G.J., Jackson, C.J.

Description: The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: phosphorylated-enzyme ensemble refinement
[[Category: Unreleased Structures]]
[[Category: Jackson, C.J]]
[[Category: Correy, G.J]]