5iwn - Revision history

OCA at 10:35, 6 September 2023

OCA — Wed, 06 Sep 2023 10:35:24 GMT

←Older revision		Revision as of 10:35, 6 September 2023
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	<StructureSection load='5iwn' size='340' side='right'caption='[[5iwn]], [[Resolution\|resolution]] 3.75Å' scene=''>		<StructureSection load='5iwn' size='340' side='right'caption='[[5iwn]], [[Resolution\|resolution]] 3.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iwn]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_baa-1101 Atcc baa-1101~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hkt 5hkt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IWN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iwn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alkalilimnicola_ehrlichii Alkalilimnicola ehrlichii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hkt 5hkt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IWN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5hj8\|5hj8]], [[5hk6\|5hk6]], [[5hk7\|5hk7]], [[5hkd\|5hkd]], [[5iwo\|5iwo]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Mlg_0322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=351052 ATCC BAA-1101])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iwn OCA], [https://pdbe.org/5iwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iwn RCSB], [https://www.ebi.ac.uk/pdbsum/5iwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iwn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5iwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iwn OCA], [~~http~~://pdbe.org/5iwn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iwn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iwn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iwn ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q0ABW0_ALKEH Q0ABW0_ALKEH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5iwn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iwn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc baa-1101~~]]	+	[[Category: Alkalilimnicola ehrlichii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Findeisen, F]]	+	[[Category: Findeisen F]]
-	[[Category: Minor~~, D L~~]]	+	[[Category: Minor DL]]
-	[[Category: Rohaim, A]]	+	[[Category: Rohaim A]]
-	[[Category: Shaya, D]]	+	[[Category: Shaya D]]
-	~~[[Category: Bacterial sodium channel]]~~	+
-	~~[[Category: Low br]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:20, 10 June 2020

OCA — Wed, 10 Jun 2020 07:20:13 GMT

←Older revision		Revision as of 07:20, 10 June 2020
Line 1:		Line 1:

	==Bacterial sodium channel pore domain, high bromide==		==Bacterial sodium channel pore domain, high bromide==
-	<StructureSection load='5iwn' size='340' side='right' caption='[[5iwn]], [[Resolution\|resolution]] 3.75Å' scene=''>	+	<StructureSection load='5iwn' size='340' side='right'caption='[[5iwn]], [[Resolution\|resolution]] 3.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iwn]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hkt 5hkt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IWN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iwn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_baa-1101 Atcc baa-1101]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hkt 5hkt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IWN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IWN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hj8\|5hj8]], [[5hk6\|5hk6]], [[5hk7\|5hk7]], [[5hkd\|5hkd]], [[5iwo\|5iwo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hj8\|5hj8]], [[5hk6\|5hk6]], [[5hk7\|5hk7]], [[5hkd\|5hkd]], [[5iwo\|5iwo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iwn OCA], [http://pdbe.org/5iwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iwn RCSB], [http://www.ebi.ac.uk/pdbsum/5iwn PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mlg_0322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=351052 ATCC BAA-1101])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iwn OCA], [http://pdbe.org/5iwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iwn RCSB], [http://www.ebi.ac.uk/pdbsum/5iwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iwn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc baa-1101]]
		+	[[Category: Large Structures]]
	[[Category: Findeisen, F]]		[[Category: Findeisen, F]]
	[[Category: Minor, D L]]		[[Category: Minor, D L]]

OCA: Protected "5iwn" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 03:24:25 GMT

Protected "5iwn" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:24, 11 May 2016

OCA: New page: ==Bacterial sodium channel pore domain, high bromide== == Structu...

OCA — Wed, 11 May 2016 03:24:23 GMT

New page: ==Bacterial sodium channel pore domain, high bromide== <StructureSection load='5iwn' size='340' side='right' caption='5iwn, resolution 3.75Å' scene=''> == Structu...

New page

==Bacterial sodium channel pore domain, high bromide==
<StructureSection load='5iwn' size='340' side='right' caption='[[5iwn]], [[Resolution|resolution]] 3.75Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5iwn]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hkt 5hkt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IWN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hj8|5hj8]], [[5hk6|5hk6]], [[5hk7|5hk7]], [[5hkd|5hkd]], [[5iwo|5iwo]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iwn OCA], [http://pdbe.org/5iwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iwn RCSB], [http://www.ebi.ac.uk/pdbsum/5iwn PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Voltage-gated ion channels (VGICs) are outfitted with diverse cytoplasmic domains that impact function. To examine how such elements may affect VGIC behavior, we addressed how the bacterial voltage-gated sodium channel (BacNaV) C-terminal cytoplasmic domain (CTD) affects function. Our studies show that the BacNaV CTD exerts a profound influence on gating through a temperature-dependent unfolding transition in a discrete cytoplasmic domain, the neck domain, proximal to the pore. Structural and functional studies establish that the BacNaV CTD comprises a bi-partite four-helix bundle that bears an unusual hydrophilic core whose integrity is central to the unfolding mechanism and that couples directly to the channel activation gate. Together, our findings define a general principle for how the widespread four-helix bundle cytoplasmic domain architecture can control VGIC responses, uncover a mechanism underlying the diverse BacNaV voltage dependencies, and demonstrate that a discrete domain can encode the temperature-dependent response of a channel.

Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.,Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL Jr Cell. 2016 Feb 25;164(5):922-36. doi: 10.1016/j.cell.2016.02.001. PMID:26919429<ref>PMID:26919429</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5iwn" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Findeisen, F]]
[[Category: Minor, D L]]
[[Category: Rohaim, A]]
[[Category: Shaya, D]]
[[Category: Bacterial sodium channel]]
[[Category: Low br]]
[[Category: Transport protein]]