5ixc - Revision history

OCA at 10:36, 6 September 2023

OCA — Wed, 06 Sep 2023 10:36:38 GMT

←Older revision		Revision as of 10:36, 6 September 2023
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	<StructureSection load='5ixc' size='340' side='right'caption='[[5ixc]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='5ixc' size='340' side='right'caption='[[5ixc]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ixc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IXC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ixc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IXC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=7FA:METHYL+(R)~~-~~(6Z~~,~~9Z,12Z)-OCTADECA-6,9,12-TRIEN-1-YLPHOSPHONOFLUORIDATE'>7FA</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:]]</b></td><td class="sblockDat">[[5iz5\|5iz5~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7FA:METHYL+(R)-(6Z,9Z,12Z)-OCTADECA-6,9,12-TRIEN-1-YLPHOSPHONOFLUORIDATE'>7FA</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PLA2G4D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [https://pdbe.org/5ixc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [https://www.ebi.ac.uk/pdbsum/5ixc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixc ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [~~http~~://pdbe.org/5ixc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ixc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PA24D_HUMAN PA24D_HUMAN]] Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.<ref>PMID:14709560</ref>	+	[https://www.uniprot.org/uniprot/PA24D_HUMAN PA24D_HUMAN] Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.<ref>PMID:14709560</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Klein~~, M G~~]]	+	[[Category: Klein MG]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	~~[[Category: Alpha/beta hydrolase]]~~	+
-	~~[[Category: C2 domain]]~~	+
-	~~[[Category: Calcium binding]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Phospholipase]]~~	+
-	~~[[Category: Signal transduction~~]]	+

OCA at 07:20, 10 June 2020

OCA — Wed, 10 Jun 2020 07:20:52 GMT

←Older revision		Revision as of 07:20, 10 June 2020
Line 1:		Line 1:

	==Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate==		==Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate==
-	<StructureSection load='5ixc' size='340' side='right' caption='[[5ixc]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='5ixc' size='340' side='right'caption='[[5ixc]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ixc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IXC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ixc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IXC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7FA:METHYL+(R)-(6Z,9Z,12Z)-OCTADECA-6,9,12-TRIEN-1-YLPHOSPHONOFLUORIDATE'>7FA</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7FA:METHYL+(R)-(6Z,9Z,12Z)-OCTADECA-6,9,12-TRIEN-1-YLPHOSPHONOFLUORIDATE'>7FA</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iz5\|5iz5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iz5\|5iz5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G4D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [http://pdbe.org/5ixc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [http://www.ebi.ac.uk/pdbsum/5ixc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [http://pdbe.org/5ixc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [http://www.ebi.ac.uk/pdbsum/5ixc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5ixc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ixc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Klein, M G]]		[[Category: Klein, M G]]
	[[Category: Wang, H]]		[[Category: Wang, H]]

OCA at 02:39, 13 July 2016

OCA — Wed, 13 Jul 2016 02:39:38 GMT

←Older revision		Revision as of 02:39, 13 July 2016
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iz5\|5iz5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iz5\|5iz5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [http://pdbe.org/5ixc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [http://www.ebi.ac.uk/pdbsum/5ixc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [http://pdbe.org/5ixc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [http://www.ebi.ac.uk/pdbsum/5ixc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:27, 20 June 2016

OCA — Mon, 20 Jun 2016 15:27:13 GMT

←Older revision		Revision as of 15:27, 20 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ixc is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate==
		+	<StructureSection load='5ixc' size='340' side='right' caption='[[5ixc]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ixc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IXC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7FA:METHYL+(R)-(6Z,9Z,12Z)-OCTADECA-6,9,12-TRIEN-1-YLPHOSPHONOFLUORIDATE'>7FA</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5iz5\|5iz5]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [http://pdbe.org/5ixc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [http://www.ebi.ac.uk/pdbsum/5ixc PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PA24D_HUMAN PA24D_HUMAN]] Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.<ref>PMID:14709560</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytosolic phospholipases A2 (cPLA2s) consist of a family of calcium-sensitive enzymes that function to generate lipid second messengers through hydrolysis of membrane-associated glycerophospholipids. The GIVD cPLA2 (cPLA2delta) is a potential drug target for developing a selective therapeutic agent for the treatment of psoriasis. Here, we present two X-ray structures of human cPLA2delta, capturing an apo state, and in complex with a substrate-like inhibitor. Comparison of the apo and inhibitor-bound structures reveals conformational changes in a flexible cap that allows the substrate to access the relatively buried active site, providing new insight into the mechanism for substrate recognition. The cPLA2delta structure reveals an unexpected second C2 domain that was previously unrecognized from sequence alignments, placing cPLA2delta into the class of membrane-associated proteins that contain a tandem pair of C2 domains. Furthermore, our structures elucidate novel inter-domain interactions and define three potential calcium-binding sites that are likely important for regulation and activation of enzymatic activity. These findings provide novel insights into the molecular mechanisms governing cPLA2's function in signal transduction.

-	~~Authors~~:	+	Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.,Wang H, Klein MG, Snell G, Lane W, Zou H, Levin I, Li K, Sang BC J Mol Biol. 2016 Jul 3;428(13):2769-79. doi: 10.1016/j.jmb.2016.05.012. Epub 2016, May 21. PMID:27220631<ref>PMID:27220631</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ixc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Klein, M G]]
		+	[[Category: Wang, H]]
		+	[[Category: Alpha/beta hydrolase]]
		+	[[Category: C2 domain]]
		+	[[Category: Calcium binding]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Phospholipase]]
		+	[[Category: Signal transduction]]

OCA at 12:56, 1 June 2016

OCA — Wed, 01 Jun 2016 12:56:17 GMT

←Older revision		Revision as of 12:56, 1 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ixc is ON HOLD	+	The entry 5ixc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 14:50, 15 May 2016

OCA — Sun, 15 May 2016 14:50:48 GMT

←Older revision		Revision as of 14:50, 15 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ixc is ON HOLD ~~until Paper Publication~~	+	The entry 5ixc is ON HOLD

-	Authors: ~~Wang, H., Klein, M.G.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Klein, M.G]]
-	[[Category: Wang, H]]

OCA: Protected "5ixc" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:07:22 GMT

Protected "5ixc" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:07, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5ixc is ON HOLD until Paper Publication Authors: Wang, H., Klein, M.G. Description: Category: Unreleased Structures Category: Klein, M.G [...

OCA — Wed, 11 May 2016 01:07:21 GMT

New page: '''Unreleased structure''' The entry 5ixc is ON HOLD until Paper Publication Authors: Wang, H., Klein, M.G. Description: Category: Unreleased Structures Category: Klein, M.G [...

New page

'''Unreleased structure'''

The entry 5ixc is ON HOLD until Paper Publication

Authors: Wang, H., Klein, M.G.

Description:
[[Category: Unreleased Structures]]
[[Category: Klein, M.G]]
[[Category: Wang, H]]