5iyz - Revision history

OCA at 10:39, 6 September 2023

OCA — Wed, 06 Sep 2023 10:39:28 GMT

←Older revision		Revision as of 10:39, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='5iyz' size='340' side='right'caption='[[5iyz]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5iyz' size='340' side='right'caption='[[5iyz]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iyz]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IYZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IYZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iyz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IYZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4Q5:N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide'>4Q5</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4Q5:N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide'>4Q5</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5iyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iyz OCA], [~~http~~://pdbe.org/5iyz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iyz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iyz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iyz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iyz OCA], [https://pdbe.org/5iyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iyz RCSB], [https://www.ebi.ac.uk/pdbsum/5iyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iyz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).	+	[https://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]		*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]		*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]
-	*[[User:Alisa Cario\|User:Alisa Cario]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: ~~Buffalo rat]]~~	+	[[Category: Gallus gallus]]
-	~~[[Category: Chick~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bargsten, K]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Doronina, S]]	+	[[Category: Bargsten K]]
-	[[Category: Prota~~, A E~~]]	+	[[Category: Doronina S]]
-	[[Category: Steinmetz~~, M O~~]]	+	[[Category: Prota AE]]
-	[[Category: Sussman, D]]	+	[[Category: Steinmetz MO]]
-	[[Category: Waight~~, A B]]~~	+	[[Category: Sussman D]]
-	~~[[Category: Cell cycle]]~~	+	[[Category: Waight AB]]
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Tubulin fold~~]]	+

OCA at 07:22, 10 June 2020

OCA — Wed, 10 Jun 2020 07:22:18 GMT

←Older revision		Revision as of 07:22, 10 June 2020
Line 1:		Line 1:

	==Tubulin-MMAE complex==		==Tubulin-MMAE complex==
-	<StructureSection load='5iyz' size='340' side='right' caption='[[5iyz]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5iyz' size='340' side='right'caption='[[5iyz]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5iyz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IYZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IYZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5iyz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IYZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IYZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4Q5:N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide'>4Q5</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4Q5:N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide'>4Q5</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=5iyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iyz OCA], [http://pdbe.org/5iyz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iyz RCSB], [http://www.ebi.ac.uk/pdbsum/5iyz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iyz ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5iyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iyz OCA], [http://pdbe.org/5iyz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iyz RCSB], [http://www.ebi.ac.uk/pdbsum/5iyz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iyz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[Tubulin\|Tubulin]]	+	*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
		+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]		*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]
		+	*[[User:Alisa Cario\|User:Alisa Cario]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Buffalo rat]]
		+	[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Bargsten, K]]		[[Category: Bargsten, K]]
	[[Category: Doronina, S]]		[[Category: Doronina, S]]

OCA at 09:29, 19 October 2016

OCA — Wed, 19 Oct 2016 09:29:11 GMT

←Older revision		Revision as of 09:29, 19 October 2016
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5iyz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iyz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tubulin\|Tubulin]]
		+	*[[Tubulin tyrosine ligase\|Tubulin tyrosine ligase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:13, 9 September 2016

OCA — Fri, 09 Sep 2016 05:13:48 GMT

←Older revision		Revision as of 05:13, 9 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5iyz is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Tubulin-MMAE complex==
		+	<StructureSection load='5iyz' size='340' side='right' caption='[[5iyz]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5iyz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IYZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IYZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4Q5:N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide'>4Q5</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iyz OCA], [http://pdbe.org/5iyz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iyz RCSB], [http://www.ebi.ac.uk/pdbsum/5iyz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iyz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The auristatin class of microtubule destabilizers are highly potent cytotoxic agents against several cancer cell types when delivered as antibody drug conjugates. Here we describe the high resolution structures of tubulin in complex with both monomethyl auristatin E and F and unambiguously define the trans-configuration of both ligands at the Val-Dil amide bond in their tubulin bound state. Moreover, we illustrate how peptidic vinca-site agents carrying terminal carboxylate residues may exploit an observed extended hydrogen bond network with the M-loop Arg278 to greatly improve the affinity of the corresponding analogs and to maintain the M-loop in an incompatible conformation for productive lateral tubulin-tubulin contacts in microtubules. Our results highlight a potential, previously undescribed molecular mechanism by which peptidic vinca-site agents maintain unparalleled potency as microtubule-destabilizing agents.

-	~~Authors:~~ Waight~~, A.B.~~, Bargsten, K., Doronina, S., Steinmetz~~, M.O.~~, Sussman, D., Prota, ~~A.E~~.	+	Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.,Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE PLoS One. 2016 Aug 12;11(8):e0160890. doi: 10.1371/journal.pone.0160890., eCollection 2016. PMID:27518442<ref>PMID:27518442</ref>

-	~~Description: Tubulin-MMAE complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Prota, A.E~~]]	+	<div class="pdbe-citations 5iyz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
	[[Category: Bargsten, K]]		[[Category: Bargsten, K]]
	[[Category: Doronina, S]]		[[Category: Doronina, S]]
-	[[Category: Steinmetz, M.O]]	+	[[Category: Prota, A E]]
		+	[[Category: Steinmetz, M O]]
	[[Category: Sussman, D]]		[[Category: Sussman, D]]
-	[[Category: Waight, A.B]]	+	[[Category: Waight, A B]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Microtubule]]
		+	[[Category: Tubulin fold]]

OCA at 12:13, 10 August 2016

OCA — Wed, 10 Aug 2016 12:13:03 GMT

←Older revision		Revision as of 12:13, 10 August 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5iyz is ON HOLD	+	The entry 5iyz is ON HOLD until Paper Publication

	Authors: Waight, A.B., Bargsten, K., Doronina, S., Steinmetz, M.O., Sussman, D., Prota, A.E.		Authors: Waight, A.B., Bargsten, K., Doronina, S., Steinmetz, M.O., Sussman, D., Prota, A.E.

OCA: Protected "5iyz" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:11:12 GMT

Protected "5iyz" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:11, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5iyz is ON HOLD Authors: Waight, A.B., Bargsten, K., Doronina, S., Steinmetz, M.O., Sussman, D., Prota, A.E. Description: Tubulin-MMAE complex [[Ca...

OCA — Wed, 11 May 2016 01:11:10 GMT

New page: '''Unreleased structure''' The entry 5iyz is ON HOLD Authors: Waight, A.B., Bargsten, K., Doronina, S., Steinmetz, M.O., Sussman, D., Prota, A.E. Description: Tubulin-MMAE complex [[Ca...

New page

'''Unreleased structure'''

The entry 5iyz is ON HOLD

Authors: Waight, A.B., Bargsten, K., Doronina, S., Steinmetz, M.O., Sussman, D., Prota, A.E.

Description: Tubulin-MMAE complex
[[Category: Unreleased Structures]]
[[Category: Prota, A.E]]
[[Category: Bargsten, K]]
[[Category: Doronina, S]]
[[Category: Steinmetz, M.O]]
[[Category: Sussman, D]]
[[Category: Waight, A.B]]