5izu - Revision history

OCA at 10:40, 6 September 2023

OCA — Wed, 06 Sep 2023 10:40:15 GMT

←Older revision		Revision as of 10:40, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='5izu' size='340' side='right'caption='[[5izu]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='5izu' size='340' side='right'caption='[[5izu]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5izu]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5izu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IZU FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Shank3 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.494Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izu OCA], [~~http~~://pdbe.org/5izu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5izu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5izu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5izu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izu OCA], [https://pdbe.org/5izu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5izu RCSB], [https://www.ebi.ac.uk/pdbsum/5izu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5izu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SHAN3_MOUSE SHAN3_MOUSE]] Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.<ref>PMID:21423165</ref> <ref>PMID:21558424</ref> <ref>PMID:23739967</ref> <ref>PMID:24153177</ref> [[http://www.uniprot.org/uniprot/DLGP3_MOUSE DLGP3_MOUSE]] May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.	+	[https://www.uniprot.org/uniprot/SHAN3_MOUSE SHAN3_MOUSE] Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.<ref>PMID:21423165</ref> <ref>PMID:21558424</ref> <ref>PMID:23739967</ref> <ref>PMID:24153177</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Shang, Y]]	+	[[Category: Shang Y]]
-	[[Category: Zeng, M]]	+	[[Category: Zeng M]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Extension]]~~	+
-	~~[[Category: Pdz]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Sapap]]~~	+
-	~~[[Category: Shank]]~~	+
-	~~[[Category: Specific interaction]]~~	+
-	~~[[Category: Synapse~~]]	+

OCA at 07:22, 10 June 2020

OCA — Wed, 10 Jun 2020 07:22:58 GMT

←Older revision		Revision as of 07:22, 10 June 2020
Line 1:		Line 1:

	==A new binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function==		==A new binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function==
-	<StructureSection load='5izu' size='340' side='right' caption='[[5izu]], [[Resolution\|resolution]] 2.49Å' scene=''>	+	<StructureSection load='5izu' size='340' side='right'caption='[[5izu]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5izu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5izu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IZU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izu OCA], [http://pdbe.org/5izu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5izu RCSB], [http://www.ebi.ac.uk/pdbsum/5izu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5izu ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Shank3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izu OCA], [http://pdbe.org/5izu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5izu RCSB], [http://www.ebi.ac.uk/pdbsum/5izu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5izu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5izu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5izu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Shank protein\|Shank protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Shang, Y]]		[[Category: Shang, Y]]
	[[Category: Zeng, M]]		[[Category: Zeng, M]]

OCA at 05:11, 9 September 2016

OCA — Fri, 09 Sep 2016 05:11:48 GMT

←Older revision		Revision as of 05:11, 9 September 2016
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5izu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IZU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5izu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IZU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izu OCA], [http://pdbe.org/5izu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5izu RCSB], [http://www.ebi.ac.uk/pdbsum/5izu PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izu OCA], [http://pdbe.org/5izu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5izu RCSB], [http://www.ebi.ac.uk/pdbsum/5izu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5izu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:09, 1 June 2016

OCA — Wed, 01 Jun 2016 08:09:06 GMT

←Older revision		Revision as of 08:09, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5izu is ~~ON HOLD~~	+	==A new binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function==
		+	<StructureSection load='5izu' size='340' side='right' caption='[[5izu]], [[Resolution\|resolution]] 2.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5izu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IZU FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5izu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izu OCA], [http://pdbe.org/5izu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5izu RCSB], [http://www.ebi.ac.uk/pdbsum/5izu PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SHAN3_MOUSE SHAN3_MOUSE]] Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.<ref>PMID:21423165</ref> <ref>PMID:21558424</ref> <ref>PMID:23739967</ref> <ref>PMID:24153177</ref> [[http://www.uniprot.org/uniprot/DLGP3_MOUSE DLGP3_MOUSE]] May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Shank and SAPAP (synapse-associated protein 90/postsynaptic density-95-associated protein) are two highly abundant scaffold proteins that directly interact with each other to regulate excitatory synapse development and plasticity. Mutations of SAPAP, but not other reported Shank PDZ domain binders, share a significant overlap on behavioral abnormalities with the mutations of Shank both in patients and in animal models. The molecular mechanism governing the exquisite specificity of the Shank/SAPAP interaction is not clear, however. Here we report that a sequence preceding the canonical PDZ domain of Shank, together with the elongated PDZ BC loop, form another binding site for a sequence upstream of the SAPAP PDZ-binding motif, leading to a several hundred-fold increase in the affinity of the Shank/SAPAP interaction. We provide evidence that the specific interaction afforded by this newly identified site is required for Shank synaptic targeting and the Shank-induced synaptic activity increase. Our study provides a molecular explanation of how Shank and SAPAP dosage changes due to their gene copy number variations can contribute to different psychiatric disorders.

-	~~Authors~~:	+	A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function.,Zeng M, Shang Y, Guo T, He Q, Yung WH, Liu K, Zhang M Proc Natl Acad Sci U S A. 2016 May 16. pii: 201523265. PMID:27185935<ref>PMID:27185935</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5izu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Shang, Y]]
		+	[[Category: Zeng, M]]
		+	[[Category: Zhang, M]]
		+	[[Category: Extension]]
		+	[[Category: Pdz]]
		+	[[Category: Protein binding]]
		+	[[Category: Sapap]]
		+	[[Category: Shank]]
		+	[[Category: Specific interaction]]
		+	[[Category: Synapse]]

OCA at 14:55, 15 May 2016

OCA — Sun, 15 May 2016 14:55:03 GMT

←Older revision		Revision as of 14:55, 15 May 2016
Line 3:		Line 3:
	The entry 5izu is ON HOLD		The entry 5izu is ON HOLD

-	Authors: ~~Shang, Y., Zeng, M., Zhang, M.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Shang, Y]]
-	[[Category: Zeng, M]]
-	[[Category: Zhang, M]]

OCA: Protected "5izu" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:13:42 GMT

Protected "5izu" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:13, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5izu is ON HOLD Authors: Shang, Y., Zeng, M., Zhang, M. Description: Category: Unreleased Structures Category: Shang, Y [[Category: Zeng, ...

OCA — Wed, 11 May 2016 01:13:41 GMT

New page: '''Unreleased structure''' The entry 5izu is ON HOLD Authors: Shang, Y., Zeng, M., Zhang, M. Description: Category: Unreleased Structures Category: Shang, Y [[Category: Zeng, ...

New page

'''Unreleased structure'''

The entry 5izu is ON HOLD

Authors: Shang, Y., Zeng, M., Zhang, M.

Description:
[[Category: Unreleased Structures]]
[[Category: Shang, Y]]
[[Category: Zeng, M]]
[[Category: Zhang, M]]