5j12 - Revision history

OCA at 10:41, 6 September 2023

OCA — Wed, 06 Sep 2023 10:41:44 GMT

←Older revision		Revision as of 10:41, 6 September 2023
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	==Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha==		==Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha==
-	<StructureSection load='5j12' size='340' side='right' caption='[[5j12]], [[Resolution\|resolution]] 3.55Å' scene=''>	+	<StructureSection load='5j12' size='340' side='right'caption='[[5j12]], [[Resolution\|resolution]] 3.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5J12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J12 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.55Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TSLP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), Il7r ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice]), CRLF2, CRL2, ILXR, TSLPR ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [~~http~~://pdbe.org/5j12 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [https://pdbe.org/5j12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [https://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN]] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref> Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref> [[http://www.uniprot.org/uniprot/CRLF2_HUMAN CRLF2_HUMAN]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also ~~activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.<ref>PMID:11418668</ref>~~ [[~~http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE~~]] ~~Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).~~	+	[https://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref> Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref>
		+
		+	==See Also==
		+	*[[Interleukin receptor 3D structures\|Interleukin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Savvides, S N~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Verstraete, K~~]]	+	[[Category: Savvides SN]]
-	[[Category: ~~Cytokine inflammation tslp signaling complex]]~~	+	[[Category: Verstraete K]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:06, 28 February 2018

OCA — Wed, 28 Feb 2018 07:06:04 GMT

←Older revision		Revision as of 07:06, 28 February 2018
Line 1:		Line 1:

-	==~~Cytokine receptor~~ complex==	+	==Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha==
	<StructureSection load='5j12' size='340' side='right' caption='[[5j12]], [[Resolution\|resolution]] 3.55Å' scene=''>		<StructureSection load='5j12' size='340' side='right' caption='[[5j12]], [[Resolution\|resolution]] 3.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J12 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TSLP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Il7r ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), CRLF2, CRL2, ILXR, TSLPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [http://pdbe.org/5j12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [http://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [http://pdbe.org/5j12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [http://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Savvides, S N]]		[[Category: Savvides, S N]]
	[[Category: Verstraete, K]]		[[Category: Verstraete, K]]
	[[Category: Cytokine inflammation tslp signaling complex]]		[[Category: Cytokine inflammation tslp signaling complex]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 13:26, 5 April 2017

OCA — Wed, 05 Apr 2017 13:26:00 GMT

←Older revision		Revision as of 13:26, 5 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5j12 is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Cytokine receptor complex==
-		+	<StructureSection load='5j12' size='340' side='right' caption='[[5j12]], [[Resolution\|resolution]] 3.55Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5j12]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J12 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j12 OCA], [http://pdbe.org/5j12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j12 RCSB], [http://www.ebi.ac.uk/pdbsum/5j12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j12 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN]] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref> Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref> [[http://www.uniprot.org/uniprot/CRLF2_HUMAN CRLF2_HUMAN]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.<ref>PMID:11418668</ref> [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Savvides, S N]]
		+	[[Category: Verstraete, K]]
		+	[[Category: Cytokine inflammation tslp signaling complex]]
		+	[[Category: Signaling protein]]

OCA at 14:57, 15 May 2016

OCA — Sun, 15 May 2016 14:57:14 GMT

←Older revision		Revision as of 14:57, 15 May 2016
Line 3:		Line 3:
	The entry 5j12 is ON HOLD until Paper Publication		The entry 5j12 is ON HOLD until Paper Publication

-	Authors: ~~Verstraete, K., Savvides, S.N.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Savvides, S.N]]
-	[[Category: Verstraete, K]]

OCA: Protected "5j12" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:17:05 GMT

Protected "5j12" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:17, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5j12 is ON HOLD until Paper Publication Authors: Verstraete, K., Savvides, S.N. Description: Category: Unreleased Structures [[Category: Savvi...

OCA — Wed, 11 May 2016 01:17:03 GMT

New page: '''Unreleased structure''' The entry 5j12 is ON HOLD until Paper Publication Authors: Verstraete, K., Savvides, S.N. Description: Category: Unreleased Structures [[Category: Savvi...

New page

'''Unreleased structure'''

The entry 5j12 is ON HOLD until Paper Publication

Authors: Verstraete, K., Savvides, S.N.

Description:
[[Category: Unreleased Structures]]
[[Category: Savvides, S.N]]
[[Category: Verstraete, K]]