5j31 - Revision history

OCA at 10:43, 6 September 2023

OCA — Wed, 06 Sep 2023 10:43:35 GMT

←Older revision		Revision as of 10:43, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='5j31' size='340' side='right'caption='[[5j31]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5j31' size='340' side='right'caption='[[5j31]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j31]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J31 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5J31 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j31]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J31 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=ZS8:(2S)-2-AMINO-2-METHYLDEC-8-YNOIC+ACID'>ZS8</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=ZS8:(2S)-2-AMINO-2-METHYLDEC-8-YNOIC+ACID'>ZS8</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n7g\|4n7g]], [[4n7y\|4n7y]], [[4n84\|4n84]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j31 OCA], [https://pdbe.org/5j31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j31 RCSB], [https://www.ebi.ac.uk/pdbsum/5j31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j31 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YWHAZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5j31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j31 OCA], [~~http~~://pdbe.org/5j31 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5j31 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5j31 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5j31 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref>	+	[https://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bier, D]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: Cromm, P]]	+	[[Category: Bier D]]
-	[[Category: Glas, A]]	+	[[Category: Cromm P]]
-	[[Category: Grossmann, T]]	+	[[Category: Glas A]]
-	[[Category: Wallraven, K]]	+	[[Category: Grossmann T]]
-	~~[[Category: 14-3-3 protein zeta]]~~	+	[[Category: Wallraven K]]
-	~~[[Category: Alkyne cross-link]]~~	+
-	~~[[Category: Constrained peptide]]~~	+
-	~~[[Category: Protein-protein-interaction]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:26, 10 June 2020

OCA — Wed, 10 Jun 2020 07:26:48 GMT

←Older revision		Revision as of 07:26, 10 June 2020
Line 1:		Line 1:

	==Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS==		==Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS==
-	<StructureSection load='5j31' size='340' side='right' caption='[[5j31]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5j31' size='340' side='right'caption='[[5j31]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j31]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J31 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5J31 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j31]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J31 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J31 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=ZS8:(2S)-2-AMINO-2-METHYLDEC-8-YNOIC+ACID'>ZS8</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=ZS8:(2S)-2-AMINO-2-METHYLDEC-8-YNOIC+ACID'>ZS8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n7g\|4n7g]], [[4n7y\|4n7y]], [[4n84\|4n84]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n7g\|4n7g]], [[4n7y\|4n7y]], [[4n84\|4n84]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5j31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j31 OCA], [http://pdbe.org/5j31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j31 RCSB], [http://www.ebi.ac.uk/pdbsum/5j31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j31 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">YWHAZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j31 OCA], [http://pdbe.org/5j31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j31 RCSB], [http://www.ebi.ac.uk/pdbsum/5j31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j31 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5j31" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5j31" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bier, D]]		[[Category: Bier, D]]
	[[Category: Cromm, P]]		[[Category: Cromm, P]]

OCA at 17:28, 19 October 2016

OCA — Wed, 19 Oct 2016 17:28:12 GMT

←Older revision		Revision as of 17:28, 19 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5j31 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS==
		+	<StructureSection load='5j31' size='340' side='right' caption='[[5j31]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5j31]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J31 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=ZS8:(2S)-2-AMINO-2-METHYLDEC-8-YNOIC+ACID'>ZS8</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n7g\|4n7g]], [[4n7y\|4n7y]], [[4n84\|4n84]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j31 OCA], [http://pdbe.org/5j31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j31 RCSB], [http://www.ebi.ac.uk/pdbsum/5j31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j31 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Macrocyclization can be used to constrain peptides in their bioactive conformations, thereby supporting target affinity and bioactivity. In particular, for the targeting of challenging protein-protein interactions, macrocyclic peptides have proven to be very useful. Available approaches focus on the stabilization of alpha-helices, which limits their general applicability. Here we report for the first time on the use of ring-closing alkyne metathesis for the stabilization of an irregular peptide secondary structure. A small library of alkyne-crosslinked peptides provided a number of derivatives with improved target affinity relative to the linear parent peptide. In addition, we report the crystal structure of the highest-affinity derivative in a complex with its protein target 14-3-3zeta. It can be expected that the alkyne-based macrocyclization of irregular binding epitopes should give rise to new scaffolds suitable for targeting of currently intractable proteins.

-	~~Authors~~:	+	Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis.,Cromm PM, Wallraven K, Glas A, Bier D, Furstner A, Ottmann C, Grossmann TN Chembiochem. 2016 Sep 6. doi: 10.1002/cbic.201600362. PMID:27596722<ref>PMID:27596722</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5j31" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bier, D]]
		+	[[Category: Cromm, P]]
		+	[[Category: Glas, A]]
		+	[[Category: Grossmann, T]]
		+	[[Category: Wallraven, K]]
		+	[[Category: 14-3-3 protein zeta]]
		+	[[Category: Alkyne cross-link]]
		+	[[Category: Constrained peptide]]
		+	[[Category: Protein-protein-interaction]]
		+	[[Category: Signaling protein]]

OCA at 15:00, 15 May 2016

OCA — Sun, 15 May 2016 15:00:31 GMT

←Older revision		Revision as of 15:00, 15 May 2016
Line 3:		Line 3:
	The entry 5j31 is ON HOLD until Paper Publication		The entry 5j31 is ON HOLD until Paper Publication

-	Authors: ~~Wallraven, K., Cromm, P., Bier, D., Glas, A., Grossmann, T.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Wallraven, K]]
-	[[Category: Bier, D]]
-	[[Category: Cromm, P]]
-	[[Category: Grossmann, T]]
-	[[Category: Glas, A]]

OCA: Protected "5j31" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:22:25 GMT

Protected "5j31" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:22, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5j31 is ON HOLD until Paper Publication Authors: Wallraven, K., Cromm, P., Bier, D., Glas, A., Grossmann, T. Description: [[Category: Unreleased S...

OCA — Wed, 11 May 2016 01:22:24 GMT

New page: '''Unreleased structure''' The entry 5j31 is ON HOLD until Paper Publication Authors: Wallraven, K., Cromm, P., Bier, D., Glas, A., Grossmann, T. Description: [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 5j31 is ON HOLD until Paper Publication

Authors: Wallraven, K., Cromm, P., Bier, D., Glas, A., Grossmann, T.

Description:
[[Category: Unreleased Structures]]
[[Category: Wallraven, K]]
[[Category: Bier, D]]
[[Category: Cromm, P]]
[[Category: Grossmann, T]]
[[Category: Glas, A]]