5j4o - Revision history

OCA at 10:48, 6 September 2023

OCA — Wed, 06 Sep 2023 10:48:21 GMT

←Older revision		Revision as of 10:48, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='5j4o' size='340' side='right'caption='[[5j4o]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='5j4o' size='340' side='right'caption='[[5j4o]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j4o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5J4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J4O FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.54Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SPTA1, SPTA ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5j4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4o OCA], [~~http~~://pdbe.org/5j4o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5j4o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5j4o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4o OCA], [https://pdbe.org/5j4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j4o RCSB], [https://www.ebi.ac.uk/pdbsum/5j4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SPTA1_HUMAN SPTA1_HUMAN]] Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2) [MIM:[~~http~~://omim.org/entry/130600 130600]]. EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.<ref>PMID:2794061</ref> <ref>PMID:8018926</ref> <ref>PMID:1679439</ref> <ref>PMID:1878597</ref> <ref>PMID:2568862</ref> <ref>PMID:1541680</ref> <ref>PMID:8364215</ref> <ref>PMID:2384601</ref> <ref>PMID:1638030</ref> <ref>PMID:2568861</ref> <ref>PMID:8193371</ref> <ref>PMID:7772539</ref> Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:[~~http~~://omim.org/entry/266140 266140]]. HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.<ref>PMID:1878597</ref> Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3) [MIM:[~~http~~://omim.org/entry/270970 270970]]; also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.	+	[https://www.uniprot.org/uniprot/SPTA1_HUMAN SPTA1_HUMAN] Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2) [MIM:[https://omim.org/entry/130600 130600]. EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.<ref>PMID:2794061</ref> <ref>PMID:8018926</ref> <ref>PMID:1679439</ref> <ref>PMID:1878597</ref> <ref>PMID:2568862</ref> <ref>PMID:1541680</ref> <ref>PMID:8364215</ref> <ref>PMID:2384601</ref> <ref>PMID:1638030</ref> <ref>PMID:2568861</ref> <ref>PMID:8193371</ref> <ref>PMID:7772539</ref> Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:[https://omim.org/entry/266140 266140]. HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.<ref>PMID:1878597</ref> Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3) [MIM:[https://omim.org/entry/270970 270970]; also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SPTA1_HUMAN SPTA1_HUMAN]] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.	+	[https://www.uniprot.org/uniprot/SPTA1_HUMAN SPTA1_HUMAN] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

	==See Also==		==See Also==
-	*[[Spectrin\|Spectrin]]	+	*[[Spectrin 3D structures\|Spectrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cutts~~, E E~~]]	+	[[Category: Cutts EE]]
-	[[Category: Vakonakis, I]]	+	[[Category: Vakonakis I]]
-	~~[[Category: Domain]]~~	+
-	~~[[Category: Erythrocyte]]~~	+
-	~~[[Category: Helical bundle]]~~	+
-	~~[[Category: Spectrin]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 07:29, 10 June 2020

OCA — Wed, 10 Jun 2020 07:29:24 GMT

←Older revision		Revision as of 07:29, 10 June 2020
Line 1:		Line 1:

	==Structure of human erythrocytic Spectrin alpha chain repeats 16-17==		==Structure of human erythrocytic Spectrin alpha chain repeats 16-17==
-	<StructureSection load='5j4o' size='340' side='right' caption='[[5j4o]], [[Resolution\|resolution]] 1.54Å' scene=''>	+	<StructureSection load='5j4o' size='340' side='right'caption='[[5j4o]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j4o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5J4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j4o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J4O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5j4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4o OCA], [http://pdbe.org/5j4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j4o RCSB], [http://www.ebi.ac.uk/pdbsum/5j4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4o ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTA1, SPTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4o OCA], [http://pdbe.org/5j4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j4o RCSB], [http://www.ebi.ac.uk/pdbsum/5j4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SPTA1_HUMAN SPTA1_HUMAN]] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.		[[http://www.uniprot.org/uniprot/SPTA1_HUMAN SPTA1_HUMAN]] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
		+
		+	==See Also==
		+	*[[Spectrin\|Spectrin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cutts, E E]]		[[Category: Cutts, E E]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]

OCA at 11:42, 12 April 2017

OCA — Wed, 12 Apr 2017 11:42:25 GMT

←Older revision		Revision as of 11:42, 12 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5j4o is ~~ON HOLD until Paper Publication~~	+	==Structure of human erythrocytic Spectrin alpha chain repeats 16-17==
-		+	<StructureSection load='5j4o' size='340' side='right' caption='[[5j4o]], [[Resolution\|resolution]] 1.54Å' scene=''>
-	~~Authors~~: ~~Cutts~~, E.E., ~~Vakonakis~~, I.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5j4o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J4O FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~human erythrocytic Spectrin alpha chain repeats 16~~-17	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4o OCA], [http://pdbe.org/5j4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j4o RCSB], [http://www.ebi.ac.uk/pdbsum/5j4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4o ProSAT]</span></td></tr>
-	[[Category: Cutts, E.E]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SPTA1_HUMAN SPTA1_HUMAN]] Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2) [MIM:[http://omim.org/entry/130600 130600]]. EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.<ref>PMID:2794061</ref> <ref>PMID:8018926</ref> <ref>PMID:1679439</ref> <ref>PMID:1878597</ref> <ref>PMID:2568862</ref> <ref>PMID:1541680</ref> <ref>PMID:8364215</ref> <ref>PMID:2384601</ref> <ref>PMID:1638030</ref> <ref>PMID:2568861</ref> <ref>PMID:8193371</ref> <ref>PMID:7772539</ref> Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:[http://omim.org/entry/266140 266140]]. HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.<ref>PMID:1878597</ref> Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3) [MIM:[http://omim.org/entry/270970 270970]]; also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPTA1_HUMAN SPTA1_HUMAN]] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cutts, E E]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]
		+	[[Category: Domain]]
		+	[[Category: Erythrocyte]]
		+	[[Category: Helical bundle]]
		+	[[Category: Spectrin]]
		+	[[Category: Structural protein]]

OCA: Protected "5j4o" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:27:16 GMT

Protected "5j4o" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:27, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5j4o is ON HOLD until Paper Publication Authors: Cutts, E.E., Vakonakis, I. Description: Structure of human erythrocytic Spectrin alpha chain repea...

OCA — Wed, 11 May 2016 01:27:14 GMT

New page: '''Unreleased structure''' The entry 5j4o is ON HOLD until Paper Publication Authors: Cutts, E.E., Vakonakis, I. Description: Structure of human erythrocytic Spectrin alpha chain repea...

New page

'''Unreleased structure'''

The entry 5j4o is ON HOLD until Paper Publication

Authors: Cutts, E.E., Vakonakis, I.

Description: Structure of human erythrocytic Spectrin alpha chain repeats 16-17
[[Category: Unreleased Structures]]
[[Category: Cutts, E.E]]
[[Category: Vakonakis, I]]