5j8o - Revision history

OCA at 10:54, 6 September 2023

OCA — Wed, 06 Sep 2023 10:54:27 GMT

←Older revision		Revision as of 10:54, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='5j8o' size='340' side='right'caption='[[5j8o]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5j8o' size='340' side='right'caption='[[5j8o]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j8o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5J8O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J8O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6GZ:(2R)-1-({3-BROMO-4-[(2-METHYL[1,1-BIPHENYL]-3-YL)METHOXY]PHENYL}METHYL)PIPERIDINE-2-CARBOXYLIC+ACID'>6GZ</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6GZ:(2R)-1-({3-BROMO-4-[(2-METHYL[1,1-BIPHENYL]-3-YL)METHOXY]PHENYL}METHYL)PIPERIDINE-2-CARBOXYLIC+ACID'>6GZ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5j8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8o OCA], [~~http~~://pdbe.org/5j8o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5j8o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5j8o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8o OCA], [https://pdbe.org/5j8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j8o RCSB], [https://www.ebi.ac.uk/pdbsum/5j8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>	+	[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Doemling, P]]	+	[[Category: Doemling P]]
-	[[Category: Dubin, G]]	+	[[Category: Dubin G]]
-	[[Category: Grudnik, P]]	+	[[Category: Grudnik P]]
-	[[Category: Guzik, K]]	+	[[Category: Guzik K]]
-	[[Category: Holak~~, T A~~]]	+	[[Category: Holak TA]]
-	[[Category: Musielak, B]]	+	[[Category: Musielak B]]
-	[[Category: Zak~~, K M~~]]	+	[[Category: Zak KM]]
-	[[Category: Zieba~~, B J]]~~	+	[[Category: Zieba BJ]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Pd-l1]]~~	+
-	~~[[Category: Programmed cell death 1 ligand 1~~]]	+

OCA at 07:33, 10 June 2020

OCA — Wed, 10 Jun 2020 07:33:23 GMT

←Older revision		Revision as of 07:33, 10 June 2020
Line 1:		Line 1:

	==Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor==		==Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor==
-	<StructureSection load='5j8o' size='340' side='right' caption='[[5j8o]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5j8o' size='340' side='right'caption='[[5j8o]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j8o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5J8O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j8o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J8O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6GZ:(2R)-1-({3-BROMO-4-[(2-METHYL[1,1-BIPHENYL]-3-YL)METHOXY]PHENYL}METHYL)PIPERIDINE-2-CARBOXYLIC+ACID'>6GZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6GZ:(2R)-1-({3-BROMO-4-[(2-METHYL[1,1-BIPHENYL]-3-YL)METHOXY]PHENYL}METHYL)PIPERIDINE-2-CARBOXYLIC+ACID'>6GZ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5j8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8o OCA], [http://pdbe.org/5j8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8o RCSB], [http://www.ebi.ac.uk/pdbsum/5j8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8o ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8o OCA], [http://pdbe.org/5j8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8o RCSB], [http://www.ebi.ac.uk/pdbsum/5j8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Doemling, P]]		[[Category: Doemling, P]]
	[[Category: Dubin, G]]		[[Category: Dubin, G]]

OCA at 08:26, 14 September 2016

OCA — Wed, 14 Sep 2016 08:26:56 GMT

←Older revision		Revision as of 08:26, 14 September 2016
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[5j8o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8O FirstGlance]. <br>		<table><tr><td colspan='2'>[[5j8o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6GZ:(2R)-1-({3-BROMO-4-[(2-METHYL[1,1-BIPHENYL]-3-YL)METHOXY]PHENYL}METHYL)PIPERIDINE-2-CARBOXYLIC+ACID'>6GZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6GZ:(2R)-1-({3-BROMO-4-[(2-METHYL[1,1-BIPHENYL]-3-YL)METHOXY]PHENYL}METHYL)PIPERIDINE-2-CARBOXYLIC+ACID'>6GZ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8o OCA], [http://pdbe.org/5j8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8o RCSB], [http://www.ebi.ac.uk/pdbsum/5j8o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8o OCA], [http://pdbe.org/5j8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8o RCSB], [http://www.ebi.ac.uk/pdbsum/5j8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA: Protected "5j8o" [edit=sysop:move=sysop]

OCA — Fri, 13 May 2016 12:10:30 GMT

Protected "5j8o" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:10, 13 May 2016

OCA: New page: ==Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor== == Structural highlights ==
<table><tr><td colspan='2'>[[5j8o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6GZ:(2R)-1-({3-BROMO-4-[(2-METHYL[1,1-BIPHENYL]-3-YL)METHOXY]PHENYL}METHYL)PIPERIDINE-2-CARBOXYLIC+ACID'>6GZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8o OCA], [http://pdbe.org/5j8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8o RCSB], [http://www.ebi.ac.uk/pdbsum/5j8o PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has provided unprecedented results in cancer treatment in the recent years. Development of chemical inhibitors for this pathway lags the antibody development because of insufficient structural information. The first nonpeptidic chemical inhibitors that target the PD-1/PD-L1 interaction have only been recently disclosed by Bristol-Myers Squibb. Here, we show that these small-molecule compounds bind directly to PD-L1 and that they potently block PD-1 binding. Structural studies reveal a dimeric protein complex with a single small molecule which stabilizes the dimer thus occluding the PD-1 interaction surface of PD-L1s. The small-molecule interaction "hot spots" on PD-L1 surfaces suggest approaches for the PD-1/PD-L1 antagonist drug discovery.

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).,Zak KM, Grudnik P, Guzik K, Zieba BJ, Musielak B, Domling A, Dubin G, Holak TA Oncotarget. 2016 Apr 13. doi: 10.18632/oncotarget.8730. PMID:27083005<ref>PMID:27083005</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5j8o" style="background-color:#fffaf0;"></div>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Doemling, P]]
[[Category: Dubin, G]]
[[Category: Grudnik, P]]
[[Category: Guzik, K]]
[[Category: Holak, T A]]
[[Category: Musielak, B]]
[[Category: Zak, K M]]
[[Category: Zieba, B J]]
[[Category: Cell cycle]]
[[Category: Immune system]]
[[Category: Pd-l1]]
[[Category: Programmed cell death 1 ligand 1]]