5j8r - Revision history

OCA at 10:54, 6 September 2023

OCA — Wed, 06 Sep 2023 10:54:31 GMT

←Older revision		Revision as of 10:54, 6 September 2023
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	<StructureSection load='5j8r' size='340' side='right'caption='[[5j8r]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='5j8r' size='340' side='right'caption='[[5j8r]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j8r]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5J8R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j8r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J8R FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PTPN12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.043Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein~~-~~tyrosine-phosphatase Protein-tyrosine-phosphatase]~~, ~~with EC number~~ [~~http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8r OCA], [https://pdbe.org/5j8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j8r RCSB], [https://www.ebi.ac.uk/pdbsum/5j8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8r ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5j8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8r OCA], [~~http~~://pdbe.org/5j8r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5j8r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5j8r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8r ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTN12_HUMAN PTN12_HUMAN]] Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.<ref>PMID:17329398</ref>	+	[https://www.uniprot.org/uniprot/PTN12_HUMAN PTN12_HUMAN] Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.<ref>PMID:17329398</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Li H]]
-	[[Category: Li, H]]	+	[[Category: Sun JP]]
-	[[Category: Sun~~, J P~~]]	+	[[Category: Wang WJ]]
-	[[Category: Wang~~, W J~~]]	+	[[Category: Xiao P]]
-	[[Category: Xiao, P]]	+	[[Category: Xu YF]]
-	[[Category: Xu~~, Y F~~]]	+	[[Category: Yang F]]
-	[[Category: Yang, F]]	+	[[Category: Yu X]]
-	[[Category: Yu, X]]	+
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Tyrosine phosphorylation~~]]	+

OCA at 07:33, 10 June 2020

OCA — Wed, 10 Jun 2020 07:33:41 GMT

←Older revision		Revision as of 07:33, 10 June 2020
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	==Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant==		==Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant==
-	<StructureSection load='5j8r' size='340' side='right' caption='[[5j8r]], [[Resolution\|resolution]] 2.04Å' scene=''>	+	<StructureSection load='5j8r' size='340' side='right'caption='[[5j8r]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j8r]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8R OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5J8R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j8r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J8R FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5j8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8r OCA], [http://pdbe.org/5j8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8r RCSB], [http://www.ebi.ac.uk/pdbsum/5j8r PDBsum]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8r OCA], [http://pdbe.org/5j8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8r RCSB], [http://www.ebi.ac.uk/pdbsum/5j8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5j8r" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5j8r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA at 08:30, 1 June 2016

OCA — Wed, 01 Jun 2016 08:30:11 GMT

←Older revision		Revision as of 08:30, 1 June 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PTN12_HUMAN PTN12_HUMAN]] Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.<ref>PMID:17329398</ref>		[[http://www.uniprot.org/uniprot/PTN12_HUMAN PTN12_HUMAN]] Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.<ref>PMID:17329398</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PTPN12 is an important tumor suppressor that plays critical roles in various physiological processes. However, the molecular basis underlying the substrate specificity of PTPN12 remains uncertain. Here, enzymological and crystallographic studies have enabled us to identify two distinct structural features that are crucial determinants of PTPN12 substrate specificity: the pY+1 site binding pocket and specific basic charged residues along its surface loops. Key structurally plastic regions and specific residues in PTPN12 enabled recognition of different HER2 phosphorylation sites and regulated specific PTPN12 functions. In addition, the structure of PTPN12 revealed a CDK2 phosphorylation site in a specific PTPN12 loop. Taken together, our results not only provide the working mechanisms of PTPN12 for desphosphorylation of its substrates but will also help in designing specific inhibitors of PTPN12.
		+
		+	Crystal Structure and Substrate Specificity of PTPN12.,Li H, Yang F, Liu C, Xiao P, Xu Y, Liang Z, Liu C, Wang H, Wang W, Zheng W, Zhang W, Ma X, He D, Song X, Cui F, Xu Z, Yi F, Sun JP, Yu X Cell Rep. 2016 May 10;15(6):1345-58. doi: 10.1016/j.celrep.2016.04.016. Epub 2016, Apr 28. PMID:27134172<ref>PMID:27134172</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5j8r" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA: Protected "5j8r" [edit=sysop:move=sysop]

OCA — Fri, 13 May 2016 12:10:39 GMT

Protected "5j8r" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:10, 13 May 2016

OCA: New page: ==Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant== == Structural highlights ==
<table><tr><td colspan='2'>[[5j8r]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8R OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8R FirstGlance]. 
</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8r OCA], [http://pdbe.org/5j8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8r RCSB], [http://www.ebi.ac.uk/pdbsum/5j8r PDBsum]</td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PTN12_HUMAN PTN12_HUMAN]] Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.<ref>PMID:17329398</ref>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Li, H]]
[[Category: Sun, J P]]
[[Category: Wang, W J]]
[[Category: Xiao, P]]
[[Category: Xu, Y F]]
[[Category: Yang, F]]
[[Category: Yu, X]]
[[Category: Cancer]]
[[Category: Hydrolase]]
[[Category: Tyrosine phosphorylation]]