5j8v - Revision history

OCA at 10:54, 6 September 2023

OCA — Wed, 06 Sep 2023 10:54:38 GMT

←Older revision		Revision as of 10:54, 6 September 2023
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	<SX load='5j8v' size='340' side='right' viewer='molstar' caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>		<SX load='5j8v' size='340' side='right' viewer='molstar' caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5J8V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J8V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5j8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8v OCA], [~~http~~://pdbe.org/5j8v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5j8v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5j8v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8v ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8v OCA], [https://pdbe.org/5j8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j8v RCSB], [https://www.ebi.ac.uk/pdbsum/5j8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>	+	[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5j8v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5j8v" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ryanodine receptor 3D structures\|Ryanodine receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 24:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Sun, F]]	+	[[Category: Sun F]]
-	[[Category: Wang, X]]	+	[[Category: Wang X]]
-	[[Category: Wei, R]]	+	[[Category: Wei R]]
-	[[Category: Yin, C]]	+	[[Category: Yin C]]
-	~~[[Category: Activated by calcium ion]]~~	+
-	~~[[Category: Endoplasmic reticula]]~~	+
-	~~[[Category: Intracellular calcium ion channel]]~~	+
-	~~[[Category: Skeletal muscle]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 20:21, 10 April 2020

OCA — Fri, 10 Apr 2020 20:21:37 GMT

←Older revision		Revision as of 20:21, 10 April 2020
Line 3:		Line 3:
	<SX load='5j8v' size='340' side='right' viewer='molstar' caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>		<SX load='5j8v' size='340' side='right' viewer='molstar' caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5J8V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J8V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5j8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8v OCA], [http://pdbe.org/5j8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8v RCSB], [http://www.ebi.ac.uk/pdbsum/5j8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8v ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8v OCA], [http://pdbe.org/5j8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8v RCSB], [http://www.ebi.ac.uk/pdbsum/5j8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:37, 6 March 2020

OCA — Fri, 06 Mar 2020 18:37:51 GMT

←Older revision		Revision as of 18:37, 6 March 2020
Line 1:		Line 1:

	==Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion==		==Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion==
-	<~~StructureSection~~ load='5j8v' size='340' side='right'caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>	+	<SX load='5j8v' size='340' side='right' viewer='molstar' caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8V FirstGlance]. <br>		<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8V FirstGlance]. <br>
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Ryanodine receptor\|Ryanodine receptor]]	+	*[[Ryanodine receptor 3D structures\|Ryanodine receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]

OCA at 16:21, 11 December 2019

OCA — Wed, 11 Dec 2019 16:21:47 GMT

←Older revision		Revision as of 16:21, 11 December 2019
Line 1:		Line 1:

	==Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion==		==Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion==
-	<StructureSection load='5j8v' size='340' side='right' caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>	+	<StructureSection load='5j8v' size='340' side='right'caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8V FirstGlance]. <br>		<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8V FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Sun, F]]		[[Category: Sun, F]]

OCA at 07:27, 25 July 2018

OCA — Wed, 25 Jul 2018 07:27:46 GMT

←Older revision		Revision as of 07:27, 25 July 2018
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5j8v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5j8v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ryanodine receptor\|Ryanodine receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:19, 14 September 2016

OCA — Wed, 14 Sep 2016 15:19:38 GMT

←Older revision		Revision as of 15:19, 14 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5j8v is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion==
		+	<StructureSection load='5j8v' size='340' side='right' caption='[[5j8v]], [[Resolution\|resolution]] 4.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8V FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8v OCA], [http://pdbe.org/5j8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8v RCSB], [http://www.ebi.ac.uk/pdbsum/5j8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8v ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ryanodine receptors (RyRs) are a class of giant ion channels with molecular mass over 2.2 mega-Daltons. These channels mediate calcium signaling in a variety of cells. Since more than 80% of the RyR protein is folded into the cytoplasmic assembly and the remaining residues form the transmembrane domain, it has been hypothesized that the activation and regulation of RyR channels occur through an as yet uncharacterized long-range allosteric mechanism. Here we report the characterization of a Ca(2+)-activated open-state RyR1 structure by cryo-electron microscopy. The structure has an overall resolution of 4.9 A and a resolution of 4.2 A for the core region. In comparison with the previously determined apo/closed-state structure, we observed long-range allosteric gating of the channel upon Ca(2+) activation. In-depth structural analyses elucidated a novel channel-gating mechanism and a novel ion selectivity mechanism of RyR1. Our work not only provides structural insights into the molecular mechanisms of channel gating and regulation of RyRs, but also sheds light on structural basis for channel-gating and ion selectivity mechanisms for the six-transmembrane-helix cation channel family.

-	~~Authors: Wang, X~~., Wei, R., ~~Yin~~, C., ~~Sun~~, F.	+	Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1.,Wei R, Wang X, Zhang Y, Mukherjee S, Zhang L, Chen Q, Huang X, Jing S, Liu C, Li S, Wang G, Xu Y, Zhu S, Williams AJ, Sun F, Yin CC Cell Res. 2016 Sep;26(9):977-94. doi: 10.1038/cr.2016.99. Epub 2016 Aug 30. PMID:27573175<ref>PMID:27573175</ref>

-	~~Description: Structure~~ of ~~rabbit ryanodine receptor RyR1 open state activated by calcium ion~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Yin~~, C]]	+	<div class="pdbe-citations 5j8v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Sun, F]]
	[[Category: Wang, X]]		[[Category: Wang, X]]
	[[Category: Wei, R]]		[[Category: Wei, R]]
-	[[Category: ~~Sun~~, F]]	+	[[Category: Yin, C]]
		+	[[Category: Activated by calcium ion]]
		+	[[Category: Endoplasmic reticula]]
		+	[[Category: Intracellular calcium ion channel]]
		+	[[Category: Skeletal muscle]]
		+	[[Category: Transport protein]]

OCA at 13:10, 9 September 2016

OCA — Fri, 09 Sep 2016 13:10:10 GMT

←Older revision		Revision as of 13:10, 9 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5j8v is ON HOLD	+	The entry 5j8v is ON HOLD until Paper Publication

	Authors: Wang, X., Wei, R., Yin, C., Sun, F.		Authors: Wang, X., Wei, R., Yin, C., Sun, F.

OCA at 15:10, 15 May 2016

OCA — Sun, 15 May 2016 15:10:36 GMT

←Older revision		Revision as of 15:10, 15 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5j8v is ON HOLD ~~until sometime in the future~~	+	The entry 5j8v is ON HOLD

	Authors: Wang, X., Wei, R., Yin, C., Sun, F.		Authors: Wang, X., Wei, R., Yin, C., Sun, F.

OCA: Protected "5j8v" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:41:25 GMT

Protected "5j8v" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:41, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5j8v is ON HOLD until sometime in the future Authors: Wang, X., Wei, R., Yin, C., Sun, F. Description: Structure of rabbit ryanodine receptor RyR1 ...

OCA — Wed, 11 May 2016 01:41:24 GMT

New page: '''Unreleased structure''' The entry 5j8v is ON HOLD until sometime in the future Authors: Wang, X., Wei, R., Yin, C., Sun, F. Description: Structure of rabbit ryanodine receptor RyR1 ...

New page

'''Unreleased structure'''

The entry 5j8v is ON HOLD until sometime in the future

Authors: Wang, X., Wei, R., Yin, C., Sun, F.

Description: Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion
[[Category: Unreleased Structures]]
[[Category: Yin, C]]
[[Category: Wang, X]]
[[Category: Wei, R]]
[[Category: Sun, F]]