5jb1 - Revision history

OCA at 01:23, 28 December 2023

OCA — Thu, 28 Dec 2023 01:23:13 GMT

←Older revision		Revision as of 01:23, 28 December 2023
Line 3:		Line 3:
	<SX load='5jb1' size='340' side='right' viewer='molstar' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>		<SX load='5jb1' size='340' side='right' viewer='molstar' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hpv59 Hpv59~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_59 Human papillomavirus 59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[5j6r\|5j6r]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 6Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">ORF putative L1, L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=37115 HPV59])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [https://pdbe.org/5jb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [https://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [https://pdbe.org/5jb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [https://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]	+	[https://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Hpv59~~]]	+	[[Category: Human papillomavirus 59]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gu, Y]]	+	[[Category: Gu Y]]
-	[[Category: Li~~, S W~~]]	+	[[Category: Li SW]]
-	[[Category: Li~~, Z H~~]]	+	[[Category: Li ZH]]
-	[[Category: Yan~~, X D~~]]	+	[[Category: Yan XD]]
-	[[Category: Yu, H]]	+	[[Category: Yu H]]
-	[[Category: Zheng~~, Q B]]~~	+	[[Category: Zheng QB]]
-	~~[[Category: Capsid]]~~	+
-	~~[[Category: T=7 icosahedral]]~~	+
-	~~[[Category: Virus]]~~	+
-	~~[[Category: Virus-like particle~~]]	+

OCA at 11:27, 23 March 2022

OCA — Wed, 23 Mar 2022 11:27:32 GMT

←Older revision		Revision as of 11:27, 23 March 2022
Line 3:		Line 3:
	<SX load='5jb1' size='340' side='right' viewer='molstar' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>		<SX load='5jb1' size='340' side='right' viewer='molstar' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hpv59 Hpv59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hpv59 Hpv59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5j6r\|5j6r]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5j6r\|5j6r]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF putative L1, L1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37115 HPV59])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF putative L1, L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37115 HPV59])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [~~http~~://pdbe.org/5jb1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [https://pdbe.org/5jb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [https://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]	+	[[https://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~Major capsid protein L1~~\|~~Major capsid protein L1~~]]	+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:21, 10 April 2020

OCA — Fri, 10 Apr 2020 20:21:47 GMT

←Older revision		Revision as of 20:21, 10 April 2020
Line 3:		Line 3:
	<SX load='5jb1' size='340' side='right' viewer='molstar' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>		<SX load='5jb1' size='340' side='right' viewer='molstar' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv59 Hpv59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv59 Hpv59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5j6r\|5j6r]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5j6r\|5j6r]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF putative L1, L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37115 HPV59])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF putative L1, L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37115 HPV59])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [http://pdbe.org/5jb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [http://pdbe.org/5jb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:33, 5 March 2020

OCA — Thu, 05 Mar 2020 04:33:06 GMT

←Older revision		Revision as of 04:33, 5 March 2020
Line 1:		Line 1:

	==Pseudo-atomic structure of Human Papillomavirus Type 59 L1 Virus-like Particle==		==Pseudo-atomic structure of Human Papillomavirus Type 59 L1 Virus-like Particle==
-	<~~StructureSection~~ load='5jb1' size='340' side='right'caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>	+	<SX load='5jb1' size='340' side='right' viewer='molstar' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv59 Hpv59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv59 Hpv59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Hpv59]]		[[Category: Hpv59]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:38, 23 October 2019

OCA — Wed, 23 Oct 2019 07:38:42 GMT

←Older revision		Revision as of 07:38, 23 October 2019
Line 1:		Line 1:

	==Pseudo-atomic structure of Human Papillomavirus Type 59 L1 Virus-like Particle==		==Pseudo-atomic structure of Human Papillomavirus Type 59 L1 Virus-like Particle==
-	<StructureSection load='5jb1' size='340' side='right' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>	+	<StructureSection load='5jb1' size='340' side='right'caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv59 Hpv59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5j6r\|5j6r]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5j6r\|5j6r]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF putative L1, L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37115 HPV59])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [http://pdbe.org/5jb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [http://pdbe.org/5jb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5jb1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jb1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Major capsid protein L1\|Major capsid protein L1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hpv59]]
		+	[[Category: Large Structures]]
	[[Category: Gu, Y]]		[[Category: Gu, Y]]
	[[Category: Li, S W]]		[[Category: Li, S W]]

OCA at 17:42, 12 July 2016

OCA — Tue, 12 Jul 2016 17:42:42 GMT

←Older revision		Revision as of 17:42, 12 July 2016
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5j6r\|5j6r]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5j6r\|5j6r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [http://pdbe.org/5jb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jb1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [http://pdbe.org/5jb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]		[[http://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cervical cancer is the second most prevalent malignant tumor among women worldwide. High-risk human papillomaviruses (HPVs) are believed to be the major causative pathogens of mucosal epithelial cancers including cervical cancer. The HPV capsid is made up of 360 copies of major (L1) and 72 copies of minor (L2) capsid proteins. To date, limited high-resolution structural information about the HPV capsid has hindered attempts to understand details concerning the mechanisms by which HPV assembles and infects cells. In this study, we have constructed a pseudo-atomic model of the HPV59 L1-only capsid and demonstrate that the C-terminal arm of L1 participates in virus-host interactions. Moreover, when conjugated to a scaffold protein, keyhole limpet hemocyanin (KLH), this arm is immunogenic in vivo. These results provide new insights that will help elucidate HPV biology, and hence pave a way for the design of next-generation HPV vaccines.
		+
		+	The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction.,Li Z, Yan X, Yu H, Wang D, Song S, Li Y, He M, Hong Q, Zheng Q, Zhao Q, Gu Y, Zhang J, Janssen ME, Cardone G, Olson NH, Baker TS, Li S, Xia N Structure. 2016 Jun 7;24(6):874-85. doi: 10.1016/j.str.2016.04.008. PMID:27276427<ref>PMID:27276427</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5jb1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:57, 1 June 2016

OCA — Wed, 01 Jun 2016 15:57:49 GMT

←Older revision		Revision as of 15:57, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jb1 is ~~ON HOLD~~	+	==Pseudo-atomic structure of Human Papillomavirus Type 59 L1 Virus-like Particle==
-		+	<StructureSection load='5jb1' size='340' side='right' caption='[[5jb1]], [[Resolution\|resolution]] 6.00Å' scene=''>
-	~~Authors~~: ~~Li, Z~~.H.~~, Yan, X~~.D., ~~Yu, H~~.~~, Zheng, Q~~.B., Gu, Y., ~~Li, S~~.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5jb1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JB1 FirstGlance]. <br>
-	~~Description~~: ~~Pseudo-atomic structure~~ of ~~Human Papillomavirus Type 59~~ L1 ~~Virus-like Particle~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5j6r\|5j6r]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jb1 OCA], [http://pdbe.org/5jb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jb1 PDBsum]</span></td></tr>
-	[[Category: Yan, X.D]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gu, Y]]
		+	[[Category: Li, S W]]
		+	[[Category: Li, Z H]]
		+	[[Category: Yan, X D]]
	[[Category: Yu, H]]		[[Category: Yu, H]]
-	[[Category: Li, ~~Z.H~~]]	+	[[Category: Zheng, Q B]]
-	[[Category: ~~Gu, Y~~]]	+	[[Category: Capsid]]
-	[[Category: ~~Li, S.W~~]]	+	[[Category: T=7 icosahedral]]
-	[[Category: ~~Zheng, Q.B~~]]	+	[[Category: Virus]]
		+	[[Category: Virus-like particle]]

OCA: Protected "5jb1" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:47:05 GMT

Protected "5jb1" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:47, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jb1 is ON HOLD Authors: Li, Z.H., Yan, X.D., Yu, H., Zheng, Q.B., Gu, Y., Li, S.W. Description: Pseudo-atomic structure of Human Papillomavirus Ty...

OCA — Wed, 11 May 2016 01:47:03 GMT

New page: '''Unreleased structure''' The entry 5jb1 is ON HOLD Authors: Li, Z.H., Yan, X.D., Yu, H., Zheng, Q.B., Gu, Y., Li, S.W. Description: Pseudo-atomic structure of Human Papillomavirus Ty...

New page

'''Unreleased structure'''

The entry 5jb1 is ON HOLD

Authors: Li, Z.H., Yan, X.D., Yu, H., Zheng, Q.B., Gu, Y., Li, S.W.

Description: Pseudo-atomic structure of Human Papillomavirus Type 59 L1 Virus-like Particle
[[Category: Unreleased Structures]]
[[Category: Yan, X.D]]
[[Category: Yu, H]]
[[Category: Li, Z.H]]
[[Category: Gu, Y]]
[[Category: Li, S.W]]
[[Category: Zheng, Q.B]]