5jdr - Revision history

OCA at 11:00, 6 September 2023

OCA — Wed, 06 Sep 2023 11:00:29 GMT

←Older revision		Revision as of 11:00, 6 September 2023
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	<StructureSection load='5jdr' size='340' side='right'caption='[[5jdr]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='5jdr' size='340' side='right'caption='[[5jdr]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jdr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JDR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JDR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jdr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JDR FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CD274~~, ~~B7H1, PDCD1L1, PDCD1LG1, PDL1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jdr OCA], [~~http~~://pdbe.org/5jdr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jdr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jdr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jdr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jdr OCA], [https://pdbe.org/5jdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jdr RCSB], [https://www.ebi.ac.uk/pdbsum/5jdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jdr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>	+	[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wei, H]]	+	[[Category: Wei H]]
-	[[Category: Zhou, A]]	+	[[Category: Zhou A]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunosuppression~~]]	+

OCA at 07:44, 10 June 2020

OCA — Wed, 10 Jun 2020 07:44:13 GMT

←Older revision		Revision as of 07:44, 10 June 2020
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	==Structure of PD-L1==		==Structure of PD-L1==
-	<StructureSection load='5jdr' size='340' side='right' caption='[[5jdr]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='5jdr' size='340' side='right'caption='[[5jdr]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jdr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JDR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JDR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jdr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JDR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JDR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jdr OCA], [http://pdbe.org/5jdr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jdr RCSB], [http://www.ebi.ac.uk/pdbsum/5jdr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jdr ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jdr OCA], [http://pdbe.org/5jdr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jdr RCSB], [http://www.ebi.ac.uk/pdbsum/5jdr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jdr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Wei, H]]		[[Category: Wei, H]]
	[[Category: Zhou, A]]		[[Category: Zhou, A]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunosuppression]]		[[Category: Immunosuppression]]

OCA at 11:35, 12 April 2017

OCA — Wed, 12 Apr 2017 11:35:22 GMT

←Older revision		Revision as of 11:35, 12 April 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5jdr is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of PD-L1==
		+	<StructureSection load='5jdr' size='340' side='right' caption='[[5jdr]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jdr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JDR FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jdr OCA], [http://pdbe.org/5jdr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jdr RCSB], [http://www.ebi.ac.uk/pdbsum/5jdr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jdr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The use of antibodies to target immune checkpoints, particularly PD-1/PD-L1, has made a profound impact in the field of cancer immunotherapy. Here, we identified KN035, an anti-PD-L1 nanobody that can strongly induce T-cell responses and inhibit tumor growth. The crystal structures of KN035 complexed with PD-L1 and free PD-L1, solved here at 1.7 and 2.7 A resolution, respectively, show that KN035 competes with PD-1 (programmed death protein 1) for the same flat surface on PD-L1, mainly through a single surface loop of 21 amino acids. This loop forms two short helices and develops key hydrophobic and ionic interactions with PD-L1 residues, such as Ile54, Tyr56 and Arg113, which are also involved in PD-1 binding. The detailed mutagenesis study identified the hotspot residues of the PD-L1 surface and provides an explanation for the stronger (~1 000-fold) binding of KN035 to PD-L1 than PD-1 and its lack of binding to PD-L2. Overall, this study reveals how a single immunoglobulin-variable scaffold of KN035 or PD-1 can bind to a flat protein surface through either a single surface loop or beta-sheet strands; and provides a basis for designing new immune checkpoint blockers and generating bi-specific antibodies for combination therapy.

-	~~Authors~~:	+	Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.,Zhang F, Wei H, Wang X, Bai Y, Wang P, Wu J, Jiang X, Wang Y, Cai H, Xu T, Zhou A Cell Discov. 2017 Mar 7;3:17004. doi: 10.1038/celldisc.2017.4. eCollection 2017. PMID:28280600<ref>PMID:28280600</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5jdr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Wei, H]]
		+	[[Category: Zhou, A]]
		+	[[Category: Immune system]]
		+	[[Category: Immunosuppression]]

OCA at 10:54, 22 March 2017

OCA — Wed, 22 Mar 2017 10:54:07 GMT

←Older revision		Revision as of 10:54, 22 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jdr is ON HOLD	+	The entry 5jdr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 15:18, 15 May 2016

OCA — Sun, 15 May 2016 15:18:55 GMT

←Older revision		Revision as of 15:18, 15 May 2016
Line 3:		Line 3:
	The entry 5jdr is ON HOLD		The entry 5jdr is ON HOLD

-	Authors: ~~Zhou, A., Wei, H.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Zhou, A]]
-	[[Category: Wei, H]]

OCA: Protected "5jdr" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 01:54:20 GMT

Protected "5jdr" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:54, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jdr is ON HOLD Authors: Zhou, A., Wei, H. Description: Category: Unreleased Structures Category: Zhou, A Category: Wei, H

OCA — Wed, 11 May 2016 01:54:19 GMT

New page: '''Unreleased structure''' The entry 5jdr is ON HOLD Authors: Zhou, A., Wei, H. Description: Category: Unreleased Structures Category: Zhou, A Category: Wei, H

New page

'''Unreleased structure'''

The entry 5jdr is ON HOLD

Authors: Zhou, A., Wei, H.

Description:
[[Category: Unreleased Structures]]
[[Category: Zhou, A]]
[[Category: Wei, H]]