5jgt - Revision history

OCA at 18:51, 20 September 2023

OCA — Wed, 20 Sep 2023 18:51:28 GMT

←Older revision		Revision as of 18:51, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='5jgt' size='340' side='right'caption='[[5jgt]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='5jgt' size='340' side='right'caption='[[5jgt]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jgt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JGT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JGT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jgt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JGT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EVI:1,3~~-~~THIAZOLE-2-SULFONAMIDE'>EVI</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EVI:1,3-THIAZOLE-2-SULFONAMIDE'>EVI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jgt OCA], [https://pdbe.org/5jgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jgt RCSB], [https://www.ebi.ac.uk/pdbsum/5jgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jgt ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jgt OCA], [~~http~~://pdbe.org/5jgt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jgt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jgt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jgt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	==See Also==		==See Also==
	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]		*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
		+	*[[Lysin 3D structures\|Lysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fox~~, J M~~]]	+	[[Category: Fox JM]]
-	[[Category: Kang, K]]	+	[[Category: Kang K]]
-	[[Category: Sankaran, B]]	+	[[Category: Sankaran B]]
-	[[Category: Sastry, M]]	+	[[Category: Sastry M]]
-	[[Category: Sherman, W]]	+	[[Category: Sherman W]]
-	[[Category: Whitesides~~, G M~~]]	+	[[Category: Whitesides GM]]
-	[[Category: Zwart~~, P H]]~~	+	[[Category: Zwart PH]]
-	~~[[Category: Anhydrase]]~~	+
-	~~[[Category: Hydrophobic]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Mutant]]~~	+
-	~~[[Category: Water~~]]	+

OCA at 07:48, 10 June 2020

OCA — Wed, 10 Jun 2020 07:48:19 GMT

←Older revision		Revision as of 07:48, 10 June 2020
Line 1:		Line 1:

	==Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide==		==Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide==
-	<StructureSection load='5jgt' size='340' side='right' caption='[[5jgt]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='5jgt' size='340' side='right'caption='[[5jgt]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jgt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JGT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JGT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jgt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JGT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JGT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EVI:1,3-THIAZOLE-2-SULFONAMIDE'>EVI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EVI:1,3-THIAZOLE-2-SULFONAMIDE'>EVI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jgt OCA], [http://pdbe.org/5jgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jgt RCSB], [http://www.ebi.ac.uk/pdbsum/5jgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jgt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jgt OCA], [http://pdbe.org/5jgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jgt RCSB], [http://www.ebi.ac.uk/pdbsum/5jgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jgt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 24:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fox, J M]]		[[Category: Fox, J M]]
	[[Category: Kang, K]]		[[Category: Kang, K]]

OCA at 07:02, 29 March 2017

OCA — Wed, 29 Mar 2017 07:02:15 GMT

←Older revision		Revision as of 07:02, 29 March 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5jgt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jgt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:41, 15 March 2017

OCA — Wed, 15 Mar 2017 13:41:07 GMT

←Older revision		Revision as of 13:41, 15 March 2017
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>		[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This study uses mutants of human carbonic anhydrase (HCAII) to examine how changes in the organization of water within a binding pocket can alter the thermodynamics of protein-ligand association. Results from calorimetric, crystallographic, and theoretical analyses suggest that most mutations strengthen networks of water-mediated hydrogen bonds and reduce binding affinity by increasing the enthalpic cost and, to a lesser extent, the entropic benefit of rearranging those networks during binding. The organization of water within a binding pocket can thus determine whether the hydrophobic interactions in which it engages are enthalpy-driven or entropy-driven. Our findings highlight a possible asymmetry in protein-ligand association by suggesting that, within the confines of the binding pocket of HCAII, binding events associated with enthalpically favorable rearrangements of water are stronger than those associated with entropically favorable ones.
		+
		+	Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase.,Fox JM, Kang K, Sastry M, Sherman W, Sankaran B, Zwart PH, Whitesides GM Angew Chem Int Ed Engl. 2017 Mar 2. doi: 10.1002/anie.201609409. PMID:28252841<ref>PMID:28252841</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5jgt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:28, 18 January 2017

OCA — Wed, 18 Jan 2017 16:28:47 GMT

←Older revision		Revision as of 16:28, 18 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jgt ~~is ON HOLD until Paper Publication~~	+	==Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide==
-		+	<StructureSection load='5jgt' size='340' side='right' caption='[[5jgt]], [[Resolution\|resolution]] 1.10Å' scene=''>
-	~~Authors~~: ~~Fox, J~~.M., ~~Kang~~, K., ~~Sastry~~, M., ~~Sherman~~, W., ~~Sankaran~~, B., ~~Zwart~~, P.H., ~~Whitesides~~, G.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5jgt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JGT FirstGlance]. <br>
-	~~Description~~: ~~Water-restructuring mutations can reverse~~ the ~~thermodynamic signature~~ of ~~protein-ligand association~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EVI:1,3-THIAZOLE-2-SULFONAMIDE'>EVI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jgt OCA], [http://pdbe.org/5jgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jgt RCSB], [http://www.ebi.ac.uk/pdbsum/5jgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jgt ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carbonate dehydratase]]
		+	[[Category: Fox, J M]]
		+	[[Category: Kang, K]]
	[[Category: Sankaran, B]]		[[Category: Sankaran, B]]
		+	[[Category: Sastry, M]]
	[[Category: Sherman, W]]		[[Category: Sherman, W]]
-	[[Category: ~~Sastry~~, M]]	+	[[Category: Whitesides, G M]]
-	[[Category: ~~Kang~~, K]]	+	[[Category: Zwart, P H]]
-	[[Category: ~~Whitesides, G.M~~]]	+	[[Category: Anhydrase]]
-	[[Category: ~~Fox, J.M~~]]	+	[[Category: Hydrophobic]]
-	[[Category: ~~Zwart, P.H~~]]	+	[[Category: Lyase]]
		+	[[Category: Mutant]]
		+	[[Category: Water]]

OCA at 15:24, 15 May 2016

OCA — Sun, 15 May 2016 15:24:13 GMT

←Older revision		Revision as of 15:24, 15 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jgt is ON HOLD	+	The entry 5jgt is ON HOLD until Paper Publication

	Authors: Fox, J.M., Kang, K., Sastry, M., Sherman, W., Sankaran, B., Zwart, P.H., Whitesides, G.M.		Authors: Fox, J.M., Kang, K., Sastry, M., Sherman, W., Sankaran, B., Zwart, P.H., Whitesides, G.M.

OCA: Protected "5jgt" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 02:02:14 GMT

Protected "5jgt" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:02, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jgt is ON HOLD Authors: Fox, J.M., Kang, K., Sastry, M., Sherman, W., Sankaran, B., Zwart, P.H., Whitesides, G.M. Description: Water-restructuring...

OCA — Wed, 11 May 2016 02:02:13 GMT

New page: '''Unreleased structure''' The entry 5jgt is ON HOLD Authors: Fox, J.M., Kang, K., Sastry, M., Sherman, W., Sankaran, B., Zwart, P.H., Whitesides, G.M. Description: Water-restructuring...

New page

'''Unreleased structure'''

The entry 5jgt is ON HOLD

Authors: Fox, J.M., Kang, K., Sastry, M., Sherman, W., Sankaran, B., Zwart, P.H., Whitesides, G.M.

Description: Water-restructuring mutations can reverse the thermodynamic signature of protein-ligand association
[[Category: Unreleased Structures]]
[[Category: Sankaran, B]]
[[Category: Sherman, W]]
[[Category: Sastry, M]]
[[Category: Kang, K]]
[[Category: Whitesides, G.M]]
[[Category: Fox, J.M]]
[[Category: Zwart, P.H]]