5jhg - Revision history

OCA at 09:17, 20 March 2024

OCA — Wed, 20 Mar 2024 09:17:31 GMT

←Older revision		Revision as of 09:17, 20 March 2024
Line 13:		Line 13:
	==See Also==		==See Also==
	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]		*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
		+	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:52, 20 September 2023

OCA — Wed, 20 Sep 2023 18:52:15 GMT

←Older revision		Revision as of 18:52, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='5jhg' size='340' side='right'caption='[[5jhg]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5jhg' size='340' side='right'caption='[[5jhg]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jhg]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JHG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jhg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JHG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5jhh\|5jhh]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">ARHGEF11, KIAA0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhg OCA], [https://pdbe.org/5jhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jhg RCSB], [https://www.ebi.ac.uk/pdbsum/5jhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhg OCA], [~~http~~://pdbe.org/5jhg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jhg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jhg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>	+	[https://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.

	==See Also==		==See Also==
	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]		*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
-	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Q]]	+	[[Category: Chen Q]]
-	[[Category: Li, J]]	+	[[Category: Li J]]
-	[[Category: Miao, L]]	+	[[Category: Miao L]]
-	[[Category: Wang, F]]	+	[[Category: Wang F]]
-	[[Category: Wang, R]]	+	[[Category: Wang R]]
-	[[Category: Yan, Z]]	+	[[Category: Yan Z]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Rhoa-arhrhogef11 complex]]~~	+
-	~~[[Category: Signaling protein-transcription complex]]~~	+
-	~~[[Category: Target-based pharmaceutical design~~]]	+

OCA at 07:49, 10 June 2020

OCA — Wed, 10 Jun 2020 07:49:12 GMT

←Older revision		Revision as of 07:49, 10 June 2020
Line 1:		Line 1:

	==Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11==		==Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11==
-	<StructureSection load='5jhg' size='340' side='right' caption='[[5jhg]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5jhg' size='340' side='right'caption='[[5jhg]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jhg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JHG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jhg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JHG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jhh\|5jhh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jhh\|5jhh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhg OCA], [http://pdbe.org/5jhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhg RCSB], [http://www.ebi.ac.uk/pdbsum/5jhg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhg ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARHGEF11, KIAA0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhg OCA], [http://pdbe.org/5jhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhg RCSB], [http://www.ebi.ac.uk/pdbsum/5jhg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>		[[http://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
		+
		+	==See Also==
		+	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
		+	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Q]]		[[Category: Chen, Q]]
	[[Category: Li, J]]		[[Category: Li, J]]

OCA at 13:57, 27 April 2017

OCA — Thu, 27 Apr 2017 13:57:42 GMT

←Older revision		Revision as of 13:57, 27 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jhg is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11==
-		+	<StructureSection load='5jhg' size='340' side='right' caption='[[5jhg]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~: ~~Wang, R~~.~~, Chen, Q~~., ~~Zhang, H~~., ~~Yan, Z~~., ~~Li, J~~., ~~Miao, L~~., ~~Wang, F~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5jhg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHG FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of~~ the ~~complex between the human~~ RhoA and ~~the DH/PH domain of human ARHGEF11~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jhh\|5jhh]]</td></tr>
-	[[Category: ~~Zhang~~, H]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhg OCA], [http://pdbe.org/5jhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhg RCSB], [http://www.ebi.ac.uk/pdbsum/5jhg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, Q]]
	[[Category: Li, J]]		[[Category: Li, J]]
	[[Category: Miao, L]]		[[Category: Miao, L]]
		+	[[Category: Wang, F]]
	[[Category: Wang, R]]		[[Category: Wang, R]]
-	[[Category: Wang, F]]
-	[[Category: Chen, Q]]
	[[Category: Yan, Z]]		[[Category: Yan, Z]]
		+	[[Category: Zhang, H]]
		+	[[Category: Rhoa-arhrhogef11 complex]]
		+	[[Category: Signaling protein-transcription complex]]
		+	[[Category: Target-based pharmaceutical design]]

OCA at 15:25, 15 May 2016

OCA — Sun, 15 May 2016 15:25:31 GMT

←Older revision		Revision as of 15:25, 15 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jhg is ON HOLD	+	The entry 5jhg is ON HOLD until Paper Publication

	Authors: Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F.		Authors: Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F.

OCA: Protected "5jhg" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 02:04:34 GMT

Protected "5jhg" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:04, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jhg is ON HOLD Authors: Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F. Description: Crystal structure of the complex between t...

OCA — Wed, 11 May 2016 02:04:33 GMT

New page: '''Unreleased structure''' The entry 5jhg is ON HOLD Authors: Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F. Description: Crystal structure of the complex between t...

New page

'''Unreleased structure'''

The entry 5jhg is ON HOLD

Authors: Wang, R., Chen, Q., Zhang, H., Yan, Z., Li, J., Miao, L., Wang, F.

Description: Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11
[[Category: Unreleased Structures]]
[[Category: Zhang, H]]
[[Category: Li, J]]
[[Category: Miao, L]]
[[Category: Wang, R]]
[[Category: Wang, F]]
[[Category: Chen, Q]]
[[Category: Yan, Z]]