5jhi - Revision history

OCA at 10:11, 14 June 2023

OCA — Wed, 14 Jun 2023 10:11:28 GMT

←Older revision		Revision as of 10:11, 14 June 2023
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	==Solution structure of the de novo mini protein gEHE_06==		==Solution structure of the de novo mini protein gEHE_06==
-	<StructureSection load='5jhi' size='340' side='right'caption='[[5jhi~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5jhi' size='340' side='right'caption='[[5jhi]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jhi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jhi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JHI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhi OCA], [~~http~~://pdbe.org/5jhi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jhi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jhi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhi ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhi OCA], [https://pdbe.org/5jhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jhi RCSB], [https://www.ebi.ac.uk/pdbsum/5jhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Synthetic construct ~~sequences~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Bahl~~, C D~~]]	+	[[Category: Bahl CD]]
-	[[Category: Baker, D]]	+	[[Category: Baker D]]
-	[[Category: Buchko~~, G W~~]]	+	[[Category: Buchko GW]]
-	[[Category: Gilmore~~, J M~~]]	+	[[Category: Gilmore JM]]
-	[[Category: Pulavarti~~, S V~~]]	+	[[Category: Pulavarti SV]]
-	[[Category: Szyperski, T]]	+	[[Category: Szyperski T]]
-	~~[[Category: De novo protein~~]]	+

OCA at 07:49, 10 June 2020

OCA — Wed, 10 Jun 2020 07:49:06 GMT

←Older revision		Revision as of 07:49, 10 June 2020
Line 1:		Line 1:

	==Solution structure of the de novo mini protein gEHE_06==		==Solution structure of the de novo mini protein gEHE_06==
-	<StructureSection load='5jhi' size='340' side='right' caption='[[5jhi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5jhi' size='340' side='right'caption='[[5jhi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jhi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jhi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JHI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhi OCA], [http://pdbe.org/5jhi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhi RCSB], [http://www.ebi.ac.uk/pdbsum/5jhi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhi ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhi OCA], [http://pdbe.org/5jhi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhi RCSB], [http://www.ebi.ac.uk/pdbsum/5jhi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Synthetic construct sequences]]		[[Category: Synthetic construct sequences]]
	[[Category: Bahl, C D]]		[[Category: Bahl, C D]]

OCA at 12:54, 6 November 2017

OCA — Mon, 06 Nov 2017 12:54:28 GMT

←Older revision		Revision as of 12:54, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='5jhi' size='340' side='right' caption='[[5jhi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='5jhi' size='340' side='right' caption='[[5jhi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jhi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jhi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHI FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhi OCA], [http://pdbe.org/5jhi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhi RCSB], [http://www.ebi.ac.uk/pdbsum/5jhi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhi ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhi OCA], [http://pdbe.org/5jhi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhi RCSB], [http://www.ebi.ac.uk/pdbsum/5jhi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhi ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Synthetic construct sequences]]
	[[Category: Bahl, C D]]		[[Category: Bahl, C D]]
	[[Category: Baker, D]]		[[Category: Baker, D]]

OCA at 16:54, 3 October 2016

OCA — Mon, 03 Oct 2016 16:54:58 GMT

←Older revision		Revision as of 16:54, 3 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jhi is ~~ON HOLD until Paper~~ Publication	+	==Solution structure of the de novo mini protein gEHE_06==
		+	<StructureSection load='5jhi' size='340' side='right' caption='[[5jhi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jhi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHI FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhi OCA], [http://pdbe.org/5jhi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhi RCSB], [http://www.ebi.ac.uk/pdbsum/5jhi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhi ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks generally have shapes that have evolved to fit precisely into binding pockets on their targets. Such peptides can have excellent pharmaceutical properties, combining the stability and tissue penetration of small-molecule drugs with the specificity of much larger protein therapeutics. The ability to design constrained peptides with precisely specified tertiary structures would enable the design of shape-complementary inhibitors of arbitrary targets. Here we describe the development of computational methods for accurate de novo design of conformationally restricted peptides, and the use of these methods to design 18-47 residue, disulfide-crosslinked peptides, a subset of which are heterochiral and/or N-C backbone-cyclized. Both genetically encodable and non-canonical peptides are exceptionally stable to thermal and chemical denaturation, and 12 experimentally determined X-ray and NMR structures are nearly identical to the computational design models. The computational design methods and stable scaffolds presented here provide the basis for development of a new generation of peptide-based drugs.

-	~~Authors: Buchko~~, G~~.W.~~, Gilmore, ~~J.M.~~, ~~Bahl~~, C.B.	+	Accurate de novo design of hyperstable constrained peptides.,Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D Nature. 2016 Sep 14. doi: 10.1038/nature19791. PMID:27626386<ref>PMID:27626386</ref>

-	~~Description: Solution structure~~ of the ~~de novo miniprotein EHE_06~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Bahl~~, ~~C.B~~]]	+	<div class="pdbe-citations 5jhi" style="background-color:#fffaf0;"></div>
-	[[Category: Gilmore, J.M]]	+	== References ==
-	[[Category: ~~Buchko~~, ~~G.W~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bahl, C D]]
		+	[[Category: Baker, D]]
		+	[[Category: Buchko, G W]]
		+	[[Category: Gilmore, J M]]
		+	[[Category: Pulavarti, S V]]
		+	[[Category: Szyperski, T]]
		+	[[Category: De novo protein]]

OCA at 13:25, 1 June 2016

OCA — Wed, 01 Jun 2016 13:25:59 GMT

←Older revision		Revision as of 13:25, 1 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jhi is ON HOLD	+	The entry 5jhi is ON HOLD until Paper Publication

	Authors: Buchko, G.W., Gilmore, J.M., Bahl, C.B.		Authors: Buchko, G.W., Gilmore, J.M., Bahl, C.B.

OCA: Protected "5jhi" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 02:04:44 GMT

Protected "5jhi" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:04, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jhi is ON HOLD Authors: Buchko, G.W., Gilmore, J.M., Bahl, C.B. Description: Solution structure of the de novo miniprotein EHE_06 [[Category: Unre...

OCA — Wed, 11 May 2016 02:04:43 GMT

New page: '''Unreleased structure''' The entry 5jhi is ON HOLD Authors: Buchko, G.W., Gilmore, J.M., Bahl, C.B. Description: Solution structure of the de novo miniprotein EHE_06 [[Category: Unre...

New page

'''Unreleased structure'''

The entry 5jhi is ON HOLD

Authors: Buchko, G.W., Gilmore, J.M., Bahl, C.B.

Description: Solution structure of the de novo miniprotein EHE_06
[[Category: Unreleased Structures]]
[[Category: Bahl, C.B]]
[[Category: Gilmore, J.M]]
[[Category: Buchko, G.W]]