5jnr - Revision history

OCA at 18:59, 20 September 2023

OCA — Wed, 20 Sep 2023 18:59:56 GMT

←Older revision		Revision as of 18:59, 20 September 2023
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	<StructureSection load='5jnr' size='340' side='right'caption='[[5jnr]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5jnr' size='340' side='right'caption='[[5jnr]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jnr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JNR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jnr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JNR FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5jns\|5jns]], [[5jnt\|5jnt]], [[5jnu\|5jnu]], [[5jnv\|5jnv]], [[5jnw\|5jnw]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnr OCA], [https://pdbe.org/5jnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jnr RCSB], [https://www.ebi.ac.uk/pdbsum/5jnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnr ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnr OCA], [~~http~~://pdbe.org/5jnr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jnr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jnr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnr ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.	+	[https://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Aleshin AE]]
-	[[Category: Aleshin~~, A E~~]]	+	[[Category: Bankston L]]
-	[[Category: Bankston, L]]	+	[[Category: Bottini N]]
-	[[Category: Bottini, N]]	+	[[Category: Cadwell G]]
-	[[Category: Cadwell, G]]	+	[[Category: Liddington RC]]
-	[[Category: Liddington~~, R C~~]]	+	[[Category: Stanford SM]]
-	[[Category: Stanford~~, S M]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lmptp]]~~	+
-	~~[[Category: Lmw-ptp]]~~	+
-	~~[[Category: Protein tyrosine phosphatase~~]]	+

OCA at 12:04, 25 December 2019

OCA — Wed, 25 Dec 2019 12:04:33 GMT

←Older revision		Revision as of 12:04, 25 December 2019
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	==Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A==		==Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A==
-	<StructureSection load='5jnr' size='340' side='right' caption='[[5jnr]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5jnr' size='340' side='right'caption='[[5jnr]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jnr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNR FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jnr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNR FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Aleshin, A E]]		[[Category: Aleshin, A E]]

OCA at 18:00, 15 November 2017

OCA — Wed, 15 Nov 2017 18:00:31 GMT

←Older revision		Revision as of 18:00, 15 November 2017
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	<StructureSection load='5jnr' size='340' side='right' caption='[[5jnr]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5jnr' size='340' side='right' caption='[[5jnr]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jnr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jnr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jns\|5jns]], [[5jnt\|5jnt]], [[5jnu\|5jnu]], [[5jnv\|5jnv]], [[5jnw\|5jnw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jns\|5jns]], [[5jnt\|5jnt]], [[5jnu\|5jnu]], [[5jnv\|5jnv]], [[5jnw\|5jnw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnr OCA], [http://pdbe.org/5jnr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jnr RCSB], [http://www.ebi.ac.uk/pdbsum/5jnr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnr OCA], [http://pdbe.org/5jnr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jnr RCSB], [http://www.ebi.ac.uk/pdbsum/5jnr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnr ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Aleshin, A E]]		[[Category: Aleshin, A E]]

OCA at 04:50, 12 April 2017

OCA — Wed, 12 Apr 2017 04:50:02 GMT

←Older revision		Revision as of 04:50, 12 April 2017
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.		[[http://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMPTP) is a proposed IR phosphatase, yet its role in insulin signaling in vivo has not been defined. Here we show that global and liver-specific LMPTP deletion protects mice from high-fat diet-induced diabetes without affecting body weight. To examine the role of the catalytic activity of LMPTP, we developed a small-molecule inhibitor with a novel uncompetitive mechanism, a unique binding site at the opening of the catalytic pocket, and an exquisite selectivity over other phosphatases. This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes. Our findings suggest that LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes.
		+
		+	Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.,Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TD, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N Nat Chem Biol. 2017 Mar 27. doi: 10.1038/nchembio.2344. PMID:28346406<ref>PMID:28346406</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5jnr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:45, 29 March 2017

OCA — Wed, 29 Mar 2017 13:45:27 GMT

←Older revision		Revision as of 13:45, 29 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jnr is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A==
-		+	<StructureSection load='5jnr' size='340' side='right' caption='[[5jnr]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~: ~~Aleshin~~, A.E., ~~Liddington, R~~.C., ~~Bankston~~, L., ~~Cadwell~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5jnr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNR FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of human Low Molecular Weight~~ Protein ~~Tyrosine Phosphatase type A (LMPTP~~-A)	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jns\|5jns]], [[5jnt\|5jnt]], [[5jnu\|5jnu]], [[5jnv\|5jnv]], [[5jnw\|5jnw]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	[[Category: ~~Liddington~~, ~~R.C~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnr OCA], [http://pdbe.org/5jnr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jnr RCSB], [http://www.ebi.ac.uk/pdbsum/5jnr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: Aleshin, A E]]
		+	[[Category: Bankston, L]]
		+	[[Category: Bottini, N]]
	[[Category: Cadwell, G]]		[[Category: Cadwell, G]]
-	[[Category: ~~Aleshin~~, ~~A.E~~]]	+	[[Category: Liddington, R C]]
-	[[Category: ~~Bankston~~, L]]	+	[[Category: Stanford, S M]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lmptp]]
		+	[[Category: Lmw-ptp]]
		+	[[Category: Protein tyrosine phosphatase]]

OCA at 09:58, 9 March 2017

OCA — Thu, 09 Mar 2017 09:58:04 GMT

←Older revision		Revision as of 09:58, 9 March 2017
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	[[Category: Liddington, R.C]]		[[Category: Liddington, R.C]]
	[[Category: Cadwell, G]]		[[Category: Cadwell, G]]
-	[[Category: Bankston, L]]
	[[Category: Aleshin, A.E]]		[[Category: Aleshin, A.E]]
		+	[[Category: Bankston, L]]

OCA at 10:55, 18 January 2017

OCA — Wed, 18 Jan 2017 10:55:20 GMT

←Older revision		Revision as of 10:55, 18 January 2017
Line 5:		Line 5:
	Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.		Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.

-	Description: Crystal Structure of ~~Human~~ Low Molecular Weight ~~Phosphotyrosine~~ Phosphatase	+	Description: Crystal Structure of human Low Molecular Weight Protein Tyrosine Phosphatase type A (LMPTP-A)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Liddington, R.C]]		[[Category: Liddington, R.C]]

OCA at 23:30, 12 July 2016

OCA — Tue, 12 Jul 2016 23:30:30 GMT

←Older revision		Revision as of 23:30, 12 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jnr is ON HOLD	+	The entry 5jnr is ON HOLD until Paper Publication

	Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.		Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.

OCA: Protected "5jnr" [edit=sysop:move=sysop]

OCA — Sun, 15 May 2016 15:38:25 GMT

Protected "5jnr" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:38, 15 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jnr is ON HOLD Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G. Description: Crystal Structure of Human Low Molecular Weight Ph...

OCA — Sun, 15 May 2016 15:38:23 GMT

New page: '''Unreleased structure''' The entry 5jnr is ON HOLD Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G. Description: Crystal Structure of Human Low Molecular Weight Ph...

New page

'''Unreleased structure'''

The entry 5jnr is ON HOLD

Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.

Description: Crystal Structure of Human Low Molecular Weight Phosphotyrosine Phosphatase
[[Category: Unreleased Structures]]
[[Category: Liddington, R.C]]
[[Category: Cadwell, G]]
[[Category: Bankston, L]]
[[Category: Aleshin, A.E]]