5jps - Revision history

OCA at 19:01, 20 September 2023

OCA — Wed, 20 Sep 2023 19:01:49 GMT

←Older revision		Revision as of 19:01, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='5jps' size='340' side='right'caption='[[5jps]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='5jps' size='340' side='right'caption='[[5jps]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jps]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Zikv Zikv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JPS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JPS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jps]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JPS FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~http://en.wikipedia.org/wiki/RNA_helicase RNA helicase~~]~~, with EC number [http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jps OCA], [~~http~~://pdbe.org/5jps PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jps RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jps PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jps ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jps OCA], [https://pdbe.org/5jps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jps RCSB], [https://www.ebi.ac.uk/pdbsum/5jps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV]] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]	+	[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]

	==See Also==		==See Also==
	*[[Helicase 3D structures\|Helicase 3D structures]]		*[[Helicase 3D structures\|Helicase 3D structures]]
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: RNA helicase]]
-	[[Category: Zikv]]
-	[[Category: Jia, Z]]
-	[[Category: Wang, J]]
-	[[Category: Hydrolase]]
-	[[Category: Ns3 helicase]]
	[[Category: Zika virus]]		[[Category: Zika virus]]
		+	[[Category: Jia Z]]
		+	[[Category: Wang J]]

OCA at 11:33, 17 June 2020

OCA — Wed, 17 Jun 2020 11:33:20 GMT

←Older revision		Revision as of 11:33, 17 June 2020
Line 1:		Line 1:

	==Structure of the Zika Virus NS3 Helicase Domain==		==Structure of the Zika Virus NS3 Helicase Domain==
-	<StructureSection load='5jps' size='340' side='right' caption='[[5jps]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='5jps' size='340' side='right'caption='[[5jps]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jps]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JPS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JPS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jps]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zikv Zikv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JPS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JPS FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jps OCA], [http://pdbe.org/5jps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jps RCSB], [http://www.ebi.ac.uk/pdbsum/5jps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jps ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jps OCA], [http://pdbe.org/5jps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jps RCSB], [http://www.ebi.ac.uk/pdbsum/5jps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV]] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]		[[http://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV]] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
		+
		+	==See Also==
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: RNA helicase]]		[[Category: RNA helicase]]
		+	[[Category: Zikv]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]
	[[Category: Wang, J]]		[[Category: Wang, J]]

OCA at 15:46, 17 May 2017

OCA — Wed, 17 May 2017 15:46:35 GMT

←Older revision		Revision as of 15:46, 17 May 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jps is ~~ON HOLD until Paper Publication~~	+	==Structure of the Zika Virus NS3 Helicase Domain==
-		+	<StructureSection load='5jps' size='340' side='right' caption='[[5jps]], [[Resolution\|resolution]] 1.78Å' scene=''>
-	~~Authors~~: ~~Jia~~, Z., ~~Wang~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5jps]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JPS FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of the ~~Zika Virus~~ NS3 ~~Helicase Domain~~	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jps OCA], [http://pdbe.org/5jps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jps RCSB], [http://www.ebi.ac.uk/pdbsum/5jps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jps ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV]] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: RNA helicase]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ns3 helicase]]
		+	[[Category: Zika virus]]

OCA at 09:59, 9 March 2017

OCA — Thu, 09 Mar 2017 09:59:33 GMT

←Older revision		Revision as of 09:59, 9 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jps is ON HOLD	+	The entry 5jps is ON HOLD until Paper Publication

	Authors: Jia, Z., Wang, J.		Authors: Jia, Z., Wang, J.

OCA at 13:40, 1 June 2016

OCA — Wed, 01 Jun 2016 13:40:45 GMT

←Older revision		Revision as of 13:40, 1 June 2016
Line 3:		Line 3:
	The entry 5jps is ON HOLD		The entry 5jps is ON HOLD

-	Authors: ~~Zhihui~~ Jia, ~~Jin~~ Wang	+	Authors: Jia, Z., Wang, J.

	Description: Structure of the Zika Virus NS3 Helicase Domain		Description: Structure of the Zika Virus NS3 Helicase Domain
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Zhihui~~ Jia, ~~Jin~~ Wang]]	+	[[Category: Jia, Z]]
		+	[[Category: Wang, J]]

OCA: Protected "5jps" [edit=sysop:move=sysop]

OCA — Sun, 15 May 2016 15:43:36 GMT

Protected "5jps" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:43, 15 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jps is ON HOLD Authors: Zhihui Jia, Jin Wang Description: Structure of the Zika Virus NS3 Helicase Domain Category: Unreleased Structures [[Ca...

OCA — Sun, 15 May 2016 15:43:34 GMT

New page: '''Unreleased structure''' The entry 5jps is ON HOLD Authors: Zhihui Jia, Jin Wang Description: Structure of the Zika Virus NS3 Helicase Domain Category: Unreleased Structures [[Ca...

New page

'''Unreleased structure'''

The entry 5jps is ON HOLD

Authors: Zhihui Jia, Jin Wang

Description: Structure of the Zika Virus NS3 Helicase Domain
[[Category: Unreleased Structures]]
[[Category: Zhihui Jia, Jin Wang]]