5jqk - Revision history

OCA at 19:02, 20 September 2023

OCA — Wed, 20 Sep 2023 19:02:29 GMT

←Older revision		Revision as of 19:02, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='5jqk' size='340' side='right'caption='[[5jqk]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='5jqk' size='340' side='right'caption='[[5jqk]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jqk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jqk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JQK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MN:MANGANESE+(II)+ION'>MN</scene~~>, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PF14_0517 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=36329 PLAF7])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqk OCA], [~~http~~://pdbe.org/5jqk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jqk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jqk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqk OCA], [https://pdbe.org/5jqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jqk RCSB], [https://www.ebi.ac.uk/pdbsum/5jqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A144A2H0_PLAF7 A0A144A2H0_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Drinkwater, N]]	+	[[Category: Drinkwater N]]
-	[[Category: McGowan, S]]	+	[[Category: McGowan S]]
-	~~[[Category: Aminopeptidase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:07, 8 January 2020

OCA — Wed, 08 Jan 2020 08:07:32 GMT

←Older revision		Revision as of 08:07, 8 January 2020
Line 1:		Line 1:

	==The Xray Crystal Structure of P. falciparum Aminopeptidase P==		==The Xray Crystal Structure of P. falciparum Aminopeptidase P==
-	<StructureSection load='5jqk' size='340' side='right' caption='[[5jqk]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='5jqk' size='340' side='right'caption='[[5jqk]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jqk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jqk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JQK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF14_0517 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqk OCA], [http://pdbe.org/5jqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jqk RCSB], [http://www.ebi.ac.uk/pdbsum/5jqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqk OCA], [http://pdbe.org/5jqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jqk RCSB], [http://www.ebi.ac.uk/pdbsum/5jqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqk ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Plaf7]]
	[[Category: Drinkwater, N]]		[[Category: Drinkwater, N]]
	[[Category: McGowan, S]]		[[Category: McGowan, S]]
	[[Category: Aminopeptidase]]		[[Category: Aminopeptidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 13:56, 10 September 2016

OCA — Sat, 10 Sep 2016 13:56:41 GMT

←Older revision		Revision as of 13:56, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5jqk is ~~ON HOLD until Paper~~ Publication	+	==The Xray Crystal Structure of P. falciparum Aminopeptidase P==
		+	<StructureSection load='5jqk' size='340' side='right' caption='[[5jqk]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jqk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JQK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqk OCA], [http://pdbe.org/5jqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jqk RCSB], [http://www.ebi.ac.uk/pdbsum/5jqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqk ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malaria is one of the world's most prevalent parasitic diseases, with over 200 million cases annually. Alarmingly, the spread of drug-resistant parasites threatens the effectiveness of current antimalarials, and has made the development of novel therapeutic strategies a global health priority. Malaria parasites have a complicated lifecycle involving an asymptomatic 'liver stage' and a symptomatic 'blood stage'. During the blood stage, the parasites utilise a proteolytic cascade to digest host haemoglobin, which produces free amino acids absolutely necessary for parasite growth and reproduction. The enzymes required for haemoglobin digestion are therefore attractive therapeutic targets. The final step of the cascade is catalyzed by several metalloaminopeptidases (MAPs), including aminopeptidase P (APP). We developed a novel platform to examine the substrate fingerprint of APP from P. falciparum ( Pf APP), and show that it can catalyse the removal of any residue immediately prior to a proline. Further, we have determined the crystal structure of Pf APP, and present the first examination of the 3D structure of this essential malarial enzyme. Together, these analyses provide insight into potential mechanisms of inhibition that could be used to develop novel antimalarial therapeutics.

-	~~Authors~~:	+	Structure and Substrate Fingerprint of Aminopeptidase P from Plasmodium falciparum.,Drinkwater N, Kannan Sivaraman K, Bamert RS, Rut W, Mohamed K, Vinh NB, Scammells PJ, Drag M, McGowan S Biochem J. 2016 Jul 26. pii: BCJ20160550. PMID:27462122<ref>PMID:27462122</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5jqk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Drinkwater, N]]
		+	[[Category: McGowan, S]]
		+	[[Category: Aminopeptidase]]
		+	[[Category: Hydrolase]]

OCA at 13:42, 1 June 2016

OCA — Wed, 01 Jun 2016 13:42:11 GMT

←Older revision		Revision as of 13:42, 1 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jqk is ON HOLD	+	The entry 5jqk is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5jqk" [edit=sysop:move=sysop]

OCA — Sun, 15 May 2016 15:46:08 GMT

Protected "5jqk" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:46, 15 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jqk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Sun, 15 May 2016 15:46:07 GMT

New page: '''Unreleased structure''' The entry 5jqk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5jqk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]