5jto - Revision history

OCA at 10:12, 14 June 2023

OCA — Wed, 14 Jun 2023 10:12:09 GMT

←Older revision		Revision as of 10:12, 14 June 2023
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	==The structure of chaperone SecB in complex with unstructured proPhoA binding site d==		==The structure of chaperone SecB in complex with unstructured proPhoA binding site d==
-	<StructureSection load='5jto' size='340' side='right'caption='[[5jto~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5jto' size='340' side='right'caption='[[5jto]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jto]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Eco57 Eco57~~] and [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JTO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JTO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jto]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JTO FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jtl\|5jtl]], [[5jtm\|5jtm]], [[5jtn\|5jtn]], [[5jtq\|5jtq]], [[5jtp\|5jtp]], [[5jtr\|5jtr]]</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jto OCA], [https://pdbe.org/5jto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jto RCSB], [https://www.ebi.ac.uk/pdbsum/5jto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jto ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">secB, Z5036, ECs4487 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57]), phoA, b0383, JW0374 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkaline_phosphatase Alkaline phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.1 3.1.3.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jto OCA], [~~http~~://pdbe.org/5jto PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jto RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jto PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jto ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~SECB_ECO57 SECB_ECO57]~~] One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.	+	[https://www.uniprot.org/uniprot/SECB_ECOLI SECB_ECOLI] One of the proteins required for the normal export of some preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. Its substrates include AmpC, DegP, FhuA, FkpA, GBP, LamB, MalE (MBP), OmpA, OmpF, OmpT, OmpX, OppA, PhoE, TolB, TolC, YbgF, YcgK, YgiW and YncE.[HAMAP-Rule:MF_00821]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alkaline phosphatase~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Eco57]]~~	+	[[Category: Escherichia coli O157:H7]]
-	~~[[Category~~: ~~Ecoli~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang, C]]	+	[[Category: Huang C]]
-	[[Category: Kalodimos~~, C G~~]]	+	[[Category: Kalodimos CG]]
-	[[Category: Rossi, P]]	+	[[Category: Rossi P]]
-	[[Category: Saio, T]]	+	[[Category: Saio T]]
-	~~[[Category: Chaperone-hydrolase complex]]~~	+
-	~~[[Category: Molecular chaperone~~]]	+

OCA at 11:38, 17 June 2020

OCA — Wed, 17 Jun 2020 11:38:42 GMT

←Older revision		Revision as of 11:38, 17 June 2020
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-	~~{{Large structure}}~~	+
	==The structure of chaperone SecB in complex with unstructured proPhoA binding site d==		==The structure of chaperone SecB in complex with unstructured proPhoA binding site d==
-	<StructureSection load='5jto' size='340' side='right' caption='[[5jto]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5jto' size='340' side='right'caption='[[5jto]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jto]] is a 8 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JTO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JTO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jto]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JTO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JTO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jtl\|5jtl]], [[5jtm\|5jtm]], [[5jtn\|5jtn]], [[5jtq\|5jtq]], [[5jtp\|5jtp]], [[5jtr\|5jtr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jtl\|5jtl]], [[5jtm\|5jtm]], [[5jtn\|5jtn]], [[5jtq\|5jtq]], [[5jtp\|5jtp]], [[5jtr\|5jtr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">secB, Z5036, ECs4487 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57]), phoA, b0383, JW0374 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkaline_phosphatase Alkaline phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.1 3.1.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkaline_phosphatase Alkaline phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.1 3.1.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jto OCA], [http://pdbe.org/5jto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jto RCSB], [http://www.ebi.ac.uk/pdbsum/5jto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jto ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jto OCA], [http://pdbe.org/5jto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jto RCSB], [http://www.ebi.ac.uk/pdbsum/5jto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jto ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SECB_ECO57 SECB_ECO57]] One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.		[[http://www.uniprot.org/uniprot/SECB_ECO57 SECB_ECO57]] One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5jto" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jto" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Alkaline phosphatase 3D structures\|Alkaline phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Alkaline phosphatase]]		[[Category: Alkaline phosphatase]]
		+	[[Category: Eco57]]
		+	[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Huang, C]]		[[Category: Huang, C]]
	[[Category: Kalodimos, C G]]		[[Category: Kalodimos, C G]]

OCA at 06:52, 10 September 2016

OCA — Sat, 10 Sep 2016 06:52:57 GMT

←Older revision		Revision as of 06:52, 10 September 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	{{Large structure}}
		+	==The structure of chaperone SecB in complex with unstructured proPhoA binding site d==
		+	<StructureSection load='5jto' size='340' side='right' caption='[[5jto]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jto]] is a 8 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JTO FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jtl\|5jtl]], [[5jtm\|5jtm]], [[5jtn\|5jtn]], [[5jtq\|5jtq]], [[5jtp\|5jtp]], [[5jtr\|5jtr]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkaline_phosphatase Alkaline phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.1 3.1.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jto OCA], [http://pdbe.org/5jto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jto RCSB], [http://www.ebi.ac.uk/pdbsum/5jto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jto ProSAT]</span></td></tr>
		+	</table>
		+	{{Large structure}}
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SECB_ECO57 SECB_ECO57]] One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Molecular chaperones act on non-native proteins in the cell to prevent their aggregation, premature folding or misfolding. Different chaperones often exert distinct effects, such as acceleration or delay of folding, on client proteins via mechanisms that are poorly understood. Here we report the solution structure of SecB, a chaperone that exhibits strong antifolding activity, in complex with alkaline phosphatase and maltose-binding protein captured in their unfolded states. SecB uses long hydrophobic grooves that run around its disk-like shape to recognize and bind to multiple hydrophobic segments across the length of non-native proteins. The multivalent binding mode results in proteins wrapping around SecB. This unique complex architecture alters the kinetics of protein binding to SecB and confers strong antifolding activity on the chaperone. The data show how the different architectures of chaperones result in distinct binding modes with non-native proteins that ultimately define the activity of the chaperone.

-	~~The entry 5jto is ON HOLD until Paper Publication~~	+	Structural basis for the antifolding activity of a molecular chaperone.,Huang C, Rossi P, Saio T, Kalodimos CG Nature. 2016 Aug 8. doi: 10.1038/nature18965. PMID:27501151<ref>PMID:27501151</ref>

-	~~Authors: Huang~~, C.~~, Saio, T~~.~~, Rossi, P., Kalodimos, C.G~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~The structure of chaperone SecB in complex with unstructured proPhoA binding site d~~	+	<div class="pdbe-citations 5jto" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alkaline phosphatase]]
	[[Category: Huang, C]]		[[Category: Huang, C]]
		+	[[Category: Kalodimos, C G]]
	[[Category: Rossi, P]]		[[Category: Rossi, P]]
	[[Category: Saio, T]]		[[Category: Saio, T]]
-	[[Category: ~~Kalodimos, C.G~~]]	+	[[Category: Chaperone-hydrolase complex]]
		+	[[Category: Molecular chaperone]]

OCA at 13:06, 20 June 2016

OCA — Mon, 20 Jun 2016 13:06:32 GMT

←Older revision		Revision as of 13:06, 20 June 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jto is ON HOLD	+	The entry 5jto is ON HOLD until Paper Publication

	Authors: Huang, C., Saio, T., Rossi, P., Kalodimos, C.G.		Authors: Huang, C., Saio, T., Rossi, P., Kalodimos, C.G.

OCA: Protected "5jto" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 13:49:18 GMT

Protected "5jto" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:49, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jto is ON HOLD Authors: Huang, C., Saio, T., Rossi, P., Kalodimos, C.G. Description: The structure of chaperone SecB in complex with unstructured ...

OCA — Wed, 01 Jun 2016 13:49:17 GMT

New page: '''Unreleased structure''' The entry 5jto is ON HOLD Authors: Huang, C., Saio, T., Rossi, P., Kalodimos, C.G. Description: The structure of chaperone SecB in complex with unstructured ...

New page

'''Unreleased structure'''

The entry 5jto is ON HOLD

Authors: Huang, C., Saio, T., Rossi, P., Kalodimos, C.G.

Description: The structure of chaperone SecB in complex with unstructured proPhoA binding site d
[[Category: Unreleased Structures]]
[[Category: Huang, C]]
[[Category: Rossi, P]]
[[Category: Saio, T]]
[[Category: Kalodimos, C.G]]