5juf - Revision history

OCA at 19:07, 20 September 2023

OCA — Wed, 20 Sep 2023 19:07:31 GMT

←Older revision		Revision as of 19:07, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='5juf' size='340' side='right'caption='[[5juf]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5juf' size='340' side='right'caption='[[5juf]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5juf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strtd Strtd~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JUF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5juf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus_LMD-9 Streptococcus thermophilus LMD-9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JUF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.946Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BN551_00358 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=322159 STRTD])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juf OCA], [~~http~~://pdbe.org/5juf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5juf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5juf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5juf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juf OCA], [https://pdbe.org/5juf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5juf RCSB], [https://www.ebi.ac.uk/pdbsum/5juf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5juf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1L1QK15_STRTD A0A1L1QK15_STRTD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5juf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5juf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strtd~~]]	+	[[Category: Streptococcus thermophilus LMD-9]]
-	[[Category: Fontaine, L]]	+	[[Category: Fontaine L]]
-	[[Category: Hols, P]]	+	[[Category: Hols P]]
-	[[Category: Ledesma, L]]	+	[[Category: Ledesma L]]
-	[[Category: ~~Nessler, S]]~~	+	[[Category: Li de la Sierra-Gallay I]]
-	~~[[Category:~~ Sierra-Gallay, I ~~Li de la~~]]	+	[[Category: Nessler S]]
-	[[Category: ~~Talagas, A~~]]	+	[[Category: Talagas A]]
-	[[Category: ~~Apo]]~~	+
-	~~[[Category: Competence regulator]]~~	+
-	~~[[Category: Hth]]~~	+
-	~~[[Category: Quorum-sensor]]~~	+
-	~~[[Category: Rnpp]]~~	+
-	~~[[Category: Tpr]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcriptional activator~~]]	+

OCA at 11:40, 17 June 2020

OCA — Wed, 17 Jun 2020 11:40:11 GMT

←Older revision		Revision as of 11:40, 17 June 2020
Line 1:		Line 1:

	==Crystal structure of the apo form of ComR from S. thermophilus.==		==Crystal structure of the apo form of ComR from S. thermophilus.==
-	<StructureSection load='5juf' size='340' side='right' caption='[[5juf]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='5juf' size='340' side='right'caption='[[5juf]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5juf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JUF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5juf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strtd Strtd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JUF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juf OCA], [http://pdbe.org/5juf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5juf RCSB], [http://www.ebi.ac.uk/pdbsum/5juf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5juf ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BN551_00358 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=322159 STRTD])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juf OCA], [http://pdbe.org/5juf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5juf RCSB], [http://www.ebi.ac.uk/pdbsum/5juf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5juf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Strtd]]
	[[Category: Fontaine, L]]		[[Category: Fontaine, L]]
	[[Category: Hols, P]]		[[Category: Hols, P]]

OCA at 11:06, 15 December 2016

OCA — Thu, 15 Dec 2016 11:06:46 GMT

←Older revision		Revision as of 11:06, 15 December 2016
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juf OCA], [http://pdbe.org/5juf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5juf RCSB], [http://www.ebi.ac.uk/pdbsum/5juf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5juf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juf OCA], [http://pdbe.org/5juf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5juf RCSB], [http://www.ebi.ac.uk/pdbsum/5juf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5juf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In Gram-positive bacteria, cell-to-cell communication mainly relies on extracellular signaling peptides, which elicit a response either indirectly, by triggering a two-component phosphorelay, or directly, by binding to cytoplasmic effectors. The latter comprise the RNPP family (Rgg and original regulators Rap, NprR, PrgX and PlcR), whose members regulate important bacterial processes such as sporulation, conjugation, and virulence. RNPP proteins are increasingly considered as interesting targets for the development of new antibacterial agents. These proteins are characterized by a TPR-type peptide-binding domain, and except for Rap proteins, also contain an N-terminal HTH-type DNA-binding domain and display a transcriptional activity. Here, we elucidate the structure-function relationship of the transcription factor ComR, a new member of the RNPP family, which positively controls competence for natural DNA transformation in streptococci. ComR is directly activated by the binding of its associated pheromone XIP, the mature form of the comX/sigX-inducing-peptide ComS. The crystal structure analysis of ComR from Streptococcus thermophilus combined with a mutational analysis and in vivo assays allows us to propose an original molecular mechanism of the ComR regulation mode. XIP-binding induces release of the sequestered HTH domain and ComR dimerization to allow DNA binding. Importantly, we bring evidence that this activation mechanism is conserved and specific to ComR orthologues, demonstrating that ComR is not an Rgg protein as initially proposed, but instead constitutes a new member of the RNPP family. In addition, identification of XIP and ComR residues important for competence activation constitutes a crucial step towards the design of antagonistic strategies to control gene exchanges among streptococci.
		+
		+	Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.,Talagas A, Fontaine L, Ledesma-Garca L, Mignolet J, Li de la Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle MJ, Prehna G, Hols P, Nessler S PLoS Pathog. 2016 Dec 1;12(12):e1005980. doi: 10.1371/journal.ppat.1005980., eCollection 2016 Dec. PMID:27907189<ref>PMID:27907189</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5juf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:46, 26 October 2016

OCA — Wed, 26 Oct 2016 18:46:34 GMT

←Older revision		Revision as of 18:46, 26 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5juf is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the apo form of ComR from S. thermophilus.==
-		+	<StructureSection load='5juf' size='340' side='right' caption='[[5juf]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5juf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JUF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juf OCA], [http://pdbe.org/5juf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5juf RCSB], [http://www.ebi.ac.uk/pdbsum/5juf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5juf ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fontaine, L]]
		+	[[Category: Hols, P]]
		+	[[Category: Ledesma, L]]
		+	[[Category: Nessler, S]]
		+	[[Category: Sierra-Gallay, I Li de la]]
		+	[[Category: Talagas, A]]
		+	[[Category: Apo]]
		+	[[Category: Competence regulator]]
		+	[[Category: Hth]]
		+	[[Category: Quorum-sensor]]
		+	[[Category: Rnpp]]
		+	[[Category: Tpr]]
		+	[[Category: Transcription]]
		+	[[Category: Transcriptional activator]]

OCA at 11:44, 26 July 2016

OCA — Tue, 26 Jul 2016 11:44:27 GMT

←Older revision		Revision as of 11:44, 26 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5juf is ON HOLD	+	The entry 5juf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5juf" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 13:50:56 GMT

Protected "5juf" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:50, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5juf is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Jun 2016 13:50:54 GMT

New page: '''Unreleased structure''' The entry 5juf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5juf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]