5jw5 - Revision history

OCA at 19:12, 20 September 2023

OCA — Wed, 20 Sep 2023 19:12:18 GMT

←Older revision		Revision as of 19:12, 20 September 2023
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	<StructureSection load='5jw5' size='340' side='right'caption='[[5jw5]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5jw5' size='340' side='right'caption='[[5jw5]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jw5]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JW5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jw5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JW5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw5 OCA], [~~http~~://pdbe.org/5jw5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jw5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jw5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw5 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw5 OCA], [https://pdbe.org/5jw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jw5 RCSB], [https://www.ebi.ac.uk/pdbsum/5jw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Collins~~, P J~~]]	+	[[Category: Collins PJ]]
-	[[Category: Gamblin~~, S J~~]]	+	[[Category: Gamblin SJ]]
-	[[Category: Martin~~, S R~~]]	+	[[Category: Martin SR]]
-	[[Category: Neu, U]]	+	[[Category: Neu U]]
-	[[Category: Ogrodowicz~~, R W~~]]	+	[[Category: Ogrodowicz RW]]
-	[[Category: Skehel~~, J J~~]]	+	[[Category: Skehel JJ]]
-	[[Category: Vorlaender~~, M K~~]]	+	[[Category: Vorlaender MK]]
-	[[Category: Walker~~, P A]]~~	+	[[Category: Walker PA]]
-	~~[[Category: Antibody influenza]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 07:58, 3 April 2019

OCA — Wed, 03 Apr 2019 07:58:57 GMT

←Older revision		Revision as of 07:58, 3 April 2019
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	==Structure of MEDI8852 Fab Fragment==		==Structure of MEDI8852 Fab Fragment==
-	<StructureSection load='5jw5' size='340' side='right' caption='[[5jw5]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5jw5' size='340' side='right'caption='[[5jw5]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jw5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jw5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw5 OCA], [http://pdbe.org/5jw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw5 OCA], [http://pdbe.org/5jw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw5 ProSAT]</span></td></tr>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 04:03, 4 August 2016

OCA — Thu, 04 Aug 2016 04:03:57 GMT

←Older revision		Revision as of 04:03, 4 August 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jw5 is ~~ON HOLD until Paper~~ Publication	+	==Structure of MEDI8852 Fab Fragment==
		+	<StructureSection load='5jw5' size='340' side='right' caption='[[5jw5]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jw5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw5 OCA], [http://pdbe.org/5jw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw5 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when compared to other anti-stem antibodies. MEDI8852 is effective in mice and ferrets with a therapeutic window superior to that of oseltamivir. Crystallographic analysis of Fab alone or in complex with H5 or H7 HA proteins reveals that MEDI8852 binds through a coordinated movement of CDRs to a highly conserved epitope encompassing a hydrophobic groove in the fusion domain and a large portion of the fusion peptide, distinguishing it from other structurally characterized cross-reactive antibodies. The unprecedented breadth and potency of neutralization by MEDI8852 support its development as immunotherapy for influenza virus-infected humans.

-	~~Authors~~:	+	Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.,Kallewaard NL, Corti D, Collins PJ, Neu U, McAuliffe JM, Benjamin E, Wachter-Rosati L, Palmer-Hill FJ, Yuan AQ, Walker PA, Vorlaender MK, Bianchi S, Guarino B, De Marco A, Vanzetta F, Agatic G, Foglierini M, Pinna D, Fernandez-Rodriguez B, Fruehwirth A, Silacci C, Ogrodowicz RW, Martin SR, Sallusto F, Suzich JA, Lanzavecchia A, Zhu Q, Gamblin SJ, Skehel JJ Cell. 2016 Jul 28;166(3):596-608. doi: 10.1016/j.cell.2016.05.073. Epub 2016 Jul , 21. PMID:27453466<ref>PMID:27453466</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5jw5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Collins, P J]]
		+	[[Category: Gamblin, S J]]
		+	[[Category: Martin, S R]]
		+	[[Category: Neu, U]]
		+	[[Category: Ogrodowicz, R W]]
		+	[[Category: Skehel, J J]]
		+	[[Category: Vorlaender, M K]]
		+	[[Category: Walker, P A]]
		+	[[Category: Antibody influenza]]
		+	[[Category: Immune system]]

OCA: Protected "5jw5" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 13:55:58 GMT

Protected "5jw5" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:55, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jw5 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Jun 2016 13:55:56 GMT

New page: '''Unreleased structure''' The entry 5jw5 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5jw5 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]