5jyh - Revision history

OCA at 19:15, 20 September 2023

OCA — Wed, 20 Sep 2023 19:15:14 GMT

←Older revision		Revision as of 19:15, 20 September 2023
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	==Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi==		==Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi==
-	<StructureSection load='5jyh' size='340' side='right'caption='[[5jyh~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5jyh' size='340' side='right'caption='[[5jyh]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jyh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hofge Hofge~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JYH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hadrurus_gertschi Hadrurus gertschi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyh OCA], [~~http~~://pdbe.org/5jyh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jyh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jyh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyh ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyh OCA], [https://pdbe.org/5jyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyh RCSB], [https://www.ebi.ac.uk/pdbsum/5jyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~KBX3_HADGE KBX3_HADGE~~]~~] Hge-scorpine has~~ antibacterial activity against B.subtilis, but not against S.aureus. Also has hemolytic and cytolytic activities.<ref>PMID:18030427</ref> ~~Hge36 peptide blocks~~ Kv1.1/KCNA1 (IC(50)=185 nM) potassium channels. Shows a weak hemolytic activity.<ref>PMID:18030427</ref>	+	[https://www.uniprot.org/uniprot/KBX3_HOFGE KBX3_HOFGE] Has antibacterial activity against B.subtilis, but not against S.aureus. Also has hemolytic and cytolytic activities.<ref>PMID:18030427</ref> Blocks Kv1.1/KCNA1 (IC(50)=185 nM) potassium channels. Shows a weak hemolytic activity.<ref>PMID:18030427</ref> <ref>PMID:27314815</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hofge]]
-	[[Category: Large Structures]]
-	[[Category: Flores-Solis, D]]
-	[[Category: Rio-Portilla, F del]]
-	[[Category: Vega, R Rodriguez De La]]
-	[[Category: Antiparasitic activity]]
	[[Category: Hadrurus gertschi]]		[[Category: Hadrurus gertschi]]
-	[[Category: ~~Scorpine~~-~~like peptide~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Toxin~~]]	+	[[Category: Flores-Solis D]]
		+	[[Category: Rodriguez De La Vega R]]
		+	[[Category: Del Rio-Portilla F]]

OCA at 09:10, 25 June 2020

OCA — Thu, 25 Jun 2020 09:10:56 GMT

←Older revision		Revision as of 09:10, 25 June 2020
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	==Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi==		==Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi==
-	<StructureSection load='5jyh' size='340' side='right' caption='[[5jyh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5jyh' size='340' side='right'caption='[[5jyh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jyh]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JYH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jyh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hofge Hofge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JYH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyh OCA], [http://pdbe.org/5jyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyh RCSB], [http://www.ebi.ac.uk/pdbsum/5jyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyh ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyh OCA], [http://pdbe.org/5jyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyh RCSB], [http://www.ebi.ac.uk/pdbsum/5jyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hofge]]
		+	[[Category: Large Structures]]
	[[Category: Flores-Solis, D]]		[[Category: Flores-Solis, D]]
	[[Category: Rio-Portilla, F del]]		[[Category: Rio-Portilla, F del]]

OCA at 10:28, 13 July 2016

OCA — Wed, 13 Jul 2016 10:28:20 GMT

←Older revision		Revision as of 10:28, 13 July 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5jyh is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi==
		+	<StructureSection load='5jyh' size='340' side='right' caption='[[5jyh]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jyh]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYH FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyh OCA], [http://pdbe.org/5jyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyh RCSB], [http://www.ebi.ac.uk/pdbsum/5jyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KBX3_HADGE KBX3_HADGE]] Hge-scorpine has antibacterial activity against B.subtilis, but not against S.aureus. Also has hemolytic and cytolytic activities.<ref>PMID:18030427</ref> Hge36 peptide blocks Kv1.1/KCNA1 (IC(50)=185 nM) potassium channels. Shows a weak hemolytic activity.<ref>PMID:18030427</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Scorpine-like peptides are two domain peptides found in different scorpion venoms displaying various antimicrobial, cytolytic, and potassium channel-blocking activities. The relative contribution of each domain to their different activities remains to be elucidated. Here, we report the recombinant production, solution structure, and antiparasitic activity of Hge36, first identified as a naturally occurring truncated form of a Scorpine-like peptide from the venom of Hoffmannihadrurus gertschi. We also show that removing the first four residues from Hge36 renders a molecule with enhanced potassium channel-blocking and antiparasitic activities. Our results are important to rationalize the structure-function relationships of a pharmacologically versatile molecular scaffold.

-	~~Authors:~~ Flores-Solis, D., Rodriguez ~~De La Vega~~, R., ~~del~~ Rio-Portilla, F.	+	Solution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschi.,Flores-Solis D, Toledano Y, Rodriguez-Lima O, Cano-Sanchez P, Ramirez-Cordero BE, Landa A, Rodriguez de la Vega RC, Del Rio-Portilla F FEBS Lett. 2016 Jun 17. doi: 10.1002/1873-3468.12255. PMID:27314815<ref>PMID:27314815</ref>

-	~~Description: Solution Structure~~ of ~~Hge36: Scorpine-like Peptide from Hadrurus Gertschi~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Rodriguez De La Vega, R]]~~	+	<div class="pdbe-citations 5jyh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Flores-Solis, D]]		[[Category: Flores-Solis, D]]
-	[[Category: ~~Del~~ Rio-Portilla, F]]	+	[[Category: Rio-Portilla, F del]]
		+	[[Category: Vega, R Rodriguez De La]]
		+	[[Category: Antiparasitic activity]]
		+	[[Category: Hadrurus gertschi]]
		+	[[Category: Scorpine-like peptide]]
		+	[[Category: Toxin]]

OCA: Protected "5jyh" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:03:07 GMT

Protected "5jyh" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:03, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jyh is ON HOLD until Paper Publication Authors: Flores-Solis, D., Rodriguez De La Vega, R., del Rio-Portilla, F. Description: Solution Structure o...

OCA — Wed, 01 Jun 2016 14:03:05 GMT

New page: '''Unreleased structure''' The entry 5jyh is ON HOLD until Paper Publication Authors: Flores-Solis, D., Rodriguez De La Vega, R., del Rio-Portilla, F. Description: Solution Structure o...

New page

'''Unreleased structure'''

The entry 5jyh is ON HOLD until Paper Publication

Authors: Flores-Solis, D., Rodriguez De La Vega, R., del Rio-Portilla, F.

Description: Solution Structure of Hge36: Scorpine-like Peptide from Hadrurus Gertschi
[[Category: Unreleased Structures]]
[[Category: Rodriguez De La Vega, R]]
[[Category: Flores-Solis, D]]
[[Category: Del Rio-Portilla, F]]