5jyq - Revision history

OCA at 19:15, 20 September 2023

OCA — Wed, 20 Sep 2023 19:15:37 GMT

←Older revision		Revision as of 19:15, 20 September 2023
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	<StructureSection load='5jyq' size='340' side='right'caption='[[5jyq]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5jyq' size='340' side='right'caption='[[5jyq]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jyq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JYQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyq OCA], [~~http~~://pdbe.org/5jyq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jyq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jyq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyq OCA], [https://pdbe.org/5jyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyq RCSB], [https://www.ebi.ac.uk/pdbsum/5jyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/INS1A_CONGE INS1A_CONGE] This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock (PubMed:25605914, PubMed:27617429). It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor (INSR) and assembly of the hormone's hexameric storage form (PubMed:27617429). Despite lacking this segment, it both binds and activates human insulin receptor (long isoform (HIR-B)) with a high potency (EC(50)=16.28 nM) (PubMed:30747102, PubMed:27617429). In vivo, intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin (PubMed:25605914, PubMed:30747102). In addition, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency (PubMed:25605914). When tested on a mouse model of diabetes, this insulin also lowers blood glucose with a 10-fold lower potency than human insulin (PubMed:30747102).<ref>PMID:25605914</ref> <ref>PMID:27617429</ref> <ref>PMID:30747102</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Conus geographus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lawrence~~, M C~~]]	+	[[Category: Lawrence MC]]
-	[[Category: Menting, J]]	+	[[Category: Menting J]]
-	[[Category: Norton~~, R S~~]]	+	[[Category: Norton RS]]
-	[[Category: Safavi-Hemami, H]]	+	[[Category: Safavi-Hemami H]]
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Venom insulin~~]]	+

OCA at 12:07, 25 December 2019

OCA — Wed, 25 Dec 2019 12:07:12 GMT

←Older revision		Revision as of 12:07, 25 December 2019
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	==Structure of Conus Geographus insulin G1==		==Structure of Conus Geographus insulin G1==
-	<StructureSection load='5jyq' size='340' side='right' caption='[[5jyq]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='5jyq' size='340' side='right'caption='[[5jyq]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jyq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jyq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYQ FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5jyq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jyq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Insulin 3D Structures\|Insulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lawrence, M C]]		[[Category: Lawrence, M C]]
	[[Category: Menting, J]]		[[Category: Menting, J]]

OCA at 09:18, 3 October 2016

OCA — Mon, 03 Oct 2016 09:18:21 GMT

←Older revision		Revision as of 09:18, 3 October 2016
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyq OCA], [http://pdbe.org/5jyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyq RCSB], [http://www.ebi.ac.uk/pdbsum/5jyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyq OCA], [http://pdbe.org/5jyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyq RCSB], [http://www.ebi.ac.uk/pdbsum/5jyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyq ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Insulins in the venom of certain fish-hunting cone snails facilitate prey capture by rapidly inducing hypoglycemic shock. One such insulin, Conus geographus G1 (Con-Ins G1), is the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Removal of this segment (residues B23-B30) in human insulin results in substantial loss of receptor affinity. Here, we found that Con-Ins G1 is monomeric, strongly binds the human insulin receptor and activates receptor signaling. Con-Ins G1 thus is a naturally occurring B-chain-minimized mimetic of human insulin. Our crystal structure of Con-Ins G1 reveals a tertiary structure highly similar to that of human insulin and indicates how Con-Ins G1's lack of an equivalent to the key receptor-engaging residue PheB24 is mitigated. These findings may facilitate efforts to design ultrarapid-acting therapeutic insulins.
		+
		+	A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.,Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC Nat Struct Mol Biol. 2016 Sep 12. doi: 10.1038/nsmb.3292. PMID:27617429<ref>PMID:27617429</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5jyq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:09, 10 September 2016

OCA — Sat, 10 Sep 2016 21:09:45 GMT

←Older revision		Revision as of 21:09, 10 September 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5jyq is ~~ON HOLD until Paper Publication~~	+	==Structure of Conus Geographus insulin G1==
-		+	<StructureSection load='5jyq' size='340' side='right' caption='[[5jyq]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5jyq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyq OCA], [http://pdbe.org/5jyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyq RCSB], [http://www.ebi.ac.uk/pdbsum/5jyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyq ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lawrence, M C]]
		+	[[Category: Menting, J]]
		+	[[Category: Norton, R S]]
		+	[[Category: Safavi-Hemami, H]]
		+	[[Category: Hormone]]
		+	[[Category: Venom insulin]]

OCA at 13:15, 20 June 2016

OCA — Mon, 20 Jun 2016 13:15:47 GMT

←Older revision		Revision as of 13:15, 20 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jyq is ON HOLD	+	The entry 5jyq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5jyq" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:03:47 GMT

Protected "5jyq" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:03, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jyq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Jun 2016 14:03:46 GMT

New page: '''Unreleased structure''' The entry 5jyq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5jyq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]