5jyt - Revision history

OCA at 10:12, 14 June 2023

OCA — Wed, 14 Jun 2023 10:12:25 GMT

←Older revision		Revision as of 10:12, 14 June 2023
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	==NMR structure of foldswitch-stablized KaiB from Thermosynechococcus elongatus==		==NMR structure of foldswitch-stablized KaiB from Thermosynechococcus elongatus==
-	<StructureSection load='5jyt' size='340' side='right'caption='[[5jyt~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5jyt' size='340' side='right'caption='[[5jyt]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jyt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Theeb Theeb~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus_BP-1 Thermosynechococcus vestitus BP-1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYT FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jyv\|5jyv]], [[5jyu\|5jyu]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyt OCA], [https://pdbe.org/5jyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyt RCSB], [https://www.ebi.ac.uk/pdbsum/5jyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyt ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kaiB, tlr0482 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197221 THEEB])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyt OCA], [~~http~~://pdbe.org/5jyt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jyt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jyt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~KAIB_THEEB KAIB_THEEB~~]~~] Component~~ of the KaiABC ~~clock protein~~ complex, which constitutes the main circadian regulator in cyanobacteria. ~~The KaiABC complex may act as a promoter~~-~~non~~-~~specific transcription regulator that represses transcription, possibly by acting on the state~~ of ~~chromosome compaction. In~~ the complex, ~~it decreases~~ the ~~phosphorylation status of~~ KaiC. ~~It has no effect on~~ KaiC ~~by itself~~, ~~but instead needs~~ the ~~presence of both~~ KaiA ~~and~~ KaiC, ~~suggesting that it acts by antagonizing~~ the ~~interaction~~ between KaiA and KaiC.[HAMAP-Rule:MF_01835]	+	[https://www.uniprot.org/uniprot/KAIB_THEVB KAIB_THEVB] Key component of the KaiABC oscillator complex, which constitutes the main circadian regulator in cyanobacteria (PubMed:24112939, PubMed:16227211, PubMed:28302851). Its composition changes during the circadian cycle to control KaiC phosphorylation. KaiA stimulates KaiC autophosphorylation, while KaiB sequesters KaiA, leading to KaiC autodephosphorylation. KaiA binding to KaiC yields KaiA(2-4):KaiC(6) complexes which stimulate KaiC autophosphorylation. Phospho-Ser-431 KaiC accumulation triggers binding of KaiB to form the KaiB(6):KaiC(6) complex, leading to changes in the output regulators CikA and SasA (PubMed:28302851). KaiB switches to a thioredoxin-like fold (KaiB(fs)) in complex with KaiC (PubMed:26113641, PubMed:28302851). KaiB(6):KaiC(6) formation exposes a site for KaiA binding that sequesters KaiA from the CII domain, making the KaiC(6):KaiB(6):KaiA(12) complex that results in KaiC autodephosphorylation. Complete dephosphorylation of KaiC leads to dissociation of KaiA(2):KaiB(1), completing 1 cycle of the Kai oscillator (PubMed:28302851).<ref>PMID:16227211</ref> <ref>PMID:24112939</ref> <ref>PMID:26113641</ref> <ref>PMID:28302851</ref> A metamorphic protein which reversibly switches between an inactive tetrameric fold and a rare, thioredoxin-like monomeric fold (KaiB(fs)). KaiB(fs) binds phospho-KaiC, KaiA and CikA. KaiA and CikA compete for binding to KaiB(fs), and KaiB(fs) and SasA compete for binding to KaiC, thus the clock oscillator and output signal pathway are tightly coupled.[HAMAP-Rule:MF_01835]<ref>PMID:26113641</ref> <ref>PMID:28302851</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Theeb~~]]	+	[[Category: Thermosynechococcus vestitus BP-1]]
-	[[Category: LiWang~~, A L~~]]	+	[[Category: LiWang AL]]
-	[[Category: Tseng~~, R D]]~~	+	[[Category: Tseng RD]]
-	~~[[Category: Circadian clock]]~~	+
-	~~[[Category: Metamorphic protein]]~~	+
-	~~[[Category: Sigaling protein~~]]	+

OCA at 12:07, 25 December 2019

OCA — Wed, 25 Dec 2019 12:07:27 GMT

←Older revision		Revision as of 12:07, 25 December 2019
Line 1:		Line 1:

	==NMR structure of foldswitch-stablized KaiB from Thermosynechococcus elongatus==		==NMR structure of foldswitch-stablized KaiB from Thermosynechococcus elongatus==
-	<StructureSection load='5jyt' size='340' side='right' caption='[[5jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5jyt' size='340' side='right'caption='[[5jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYT FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5jyt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jyt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Circadian clock protein 3D structures\|Circadian clock protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Theeb]]		[[Category: Theeb]]
	[[Category: LiWang, A L]]		[[Category: LiWang, A L]]

OCA at 18:05, 15 November 2017

OCA — Wed, 15 Nov 2017 18:05:56 GMT

←Older revision		Revision as of 18:05, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5jyt' size='340' side='right' caption='[[5jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='5jyt' size='340' side='right' caption='[[5jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jyt]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theeb Theeb]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jyv\|5jyv]], [[5jyu\|5jyu]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jyv\|5jyv]], [[5jyu\|5jyu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kaiB, tlr0482 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197221 THEEB])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyt OCA], [http://pdbe.org/5jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyt RCSB], [http://www.ebi.ac.uk/pdbsum/5jyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyt OCA], [http://pdbe.org/5jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyt RCSB], [http://www.ebi.ac.uk/pdbsum/5jyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyt ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theeb]]
	[[Category: LiWang, A L]]		[[Category: LiWang, A L]]
	[[Category: Tseng, R D]]		[[Category: Tseng, R D]]

OCA at 13:45, 29 March 2017

OCA — Wed, 29 Mar 2017 13:45:59 GMT

←Older revision		Revision as of 13:45, 29 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jyt is ~~ON HOLD until Paper~~ Publication	+	==NMR structure of foldswitch-stablized KaiB from Thermosynechococcus elongatus==
		+	<StructureSection load='5jyt' size='340' side='right' caption='[[5jyt]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jyt]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYT FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jyv\|5jyv]], [[5jyu\|5jyu]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyt OCA], [http://pdbe.org/5jyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyt RCSB], [http://www.ebi.ac.uk/pdbsum/5jyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyt ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAIB_THEEB KAIB_THEEB]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC.[HAMAP-Rule:MF_01835]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Circadian clocks are ubiquitous timing systems that induce rhythms of biological activities in synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational clock consisting of KaiA, KaiB, and KaiC proteins and a set of output signaling proteins, SasA and CikA, which transduce this rhythm to control gene expression. Here, we describe crystal and nuclear magnetic resonance structures of KaiB-KaiC,KaiA-KaiB-KaiC, and CikA-KaiB complexes. They reveal how the metamorphic properties of KaiB, a protein that adopts two distinct folds, and the post-adenosine triphosphate hydrolysis state of KaiC create a hub around which nighttime signaling events revolve, including inactivation of KaiA and reciprocal regulation of the mutually antagonistic signaling proteins, SasA and CikA.

-	~~Authors~~:	+	Structural basis of the day-night transition in a bacterial circadian clock.,Tseng R, Goularte NF, Chavan A, Luu J, Cohen SE, Chang YG, Heisler J, Li S, Michael AK, Tripathi S, Golden SS, LiWang A, Partch CL Science. 2017 Mar 17;355(6330):1174-1180. doi: 10.1126/science.aag2516. Epub 2017, Mar 16. PMID:28302851<ref>PMID:28302851</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5jyt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: LiWang, A L]]
		+	[[Category: Tseng, R D]]
		+	[[Category: Circadian clock]]
		+	[[Category: Metamorphic protein]]
		+	[[Category: Sigaling protein]]

OCA: Protected "5jyt" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:04:02 GMT

Protected "5jyt" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:04, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jyt is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Jun 2016 14:04:01 GMT

New page: '''Unreleased structure''' The entry 5jyt is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5jyt is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]