5jzh - Revision history

OCA at 19:16, 20 September 2023

OCA — Wed, 20 Sep 2023 19:16:09 GMT

←Older revision		Revision as of 19:16, 20 September 2023
Line 3:		Line 3:
	<SX load='5jzh' size='340' side='right' viewer='molstar' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>		<SX load='5jzh' size='340' side='right' viewer='molstar' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JZH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JZH FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>aerA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~644~~ "~~Aeromonas liquefaciens~~" ~~Kluyver and van Niel 1936~~])</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [~~http~~://pdbe.org/5jzh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [https://pdbe.org/5jzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [https://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AERA_AERHY AERA_AERHY]] Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximately 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis.	+	[https://www.uniprot.org/uniprot/AERA_AERHY AERA_AERHY] Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximately 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Aeromonas ~~liquefaciens kluyver and van niel 1936~~]]	+	[[Category: Aeromonas hydrophila]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Iacovache, I]]	+	[[Category: Iacovache I]]
-	[[Category: Zuber, B]]	+	[[Category: Zuber B]]
-	~~[[Category: Aerolysin]]~~	+
-	~~[[Category: Concentric beta-barrel]]~~	+
-	~~[[Category: Pore forming toxin]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 20:26, 10 April 2020

OCA — Fri, 10 Apr 2020 20:26:31 GMT

←Older revision		Revision as of 20:26, 10 April 2020
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	<SX load='5jzh' size='340' side='right' viewer='molstar' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>		<SX load='5jzh' size='340' side='right' viewer='molstar' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JZH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JZH FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aerA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aerA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [http://pdbe.org/5jzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [http://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [http://pdbe.org/5jzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [http://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:45, 6 March 2020

OCA — Fri, 06 Mar 2020 18:45:06 GMT

←Older revision		Revision as of 18:45, 6 March 2020
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Cryo-EM structure of aerolysin prepore==		==Cryo-EM structure of aerolysin prepore==
-	<~~StructureSection~~ load='5jzh' size='340' side='right' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<SX load='5jzh' size='340' side='right' viewer='molstar' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JZH FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JZH FirstGlance]. <br>
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [http://pdbe.org/5jzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [http://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [http://pdbe.org/5jzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [http://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/AERA_AERHY AERA_AERHY]] Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximately 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis.		[[http://www.uniprot.org/uniprot/AERA_AERHY AERA_AERHY]] Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximately 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis.
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Aerolysin\|Aerolysin]]	+	*[[Aerolysin 3D structures\|Aerolysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Aeromonas liquefaciens kluyver and van niel 1936]]		[[Category: Aeromonas liquefaciens kluyver and van niel 1936]]
		+	[[Category: Large Structures]]
	[[Category: Iacovache, I]]		[[Category: Iacovache, I]]
	[[Category: Zuber, B]]		[[Category: Zuber, B]]

OCA at 08:23, 3 October 2018

OCA — Wed, 03 Oct 2018 08:23:49 GMT

←Older revision		Revision as of 08:23, 3 October 2018
Line 3:		Line 3:
	<StructureSection load='5jzh' size='340' side='right' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='5jzh' size='340' side='right' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JZH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JZH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [http://pdbe.org/5jzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [http://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aerA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [http://pdbe.org/5jzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [http://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aeromonas liquefaciens kluyver and van niel 1936]]
	[[Category: Iacovache, I]]		[[Category: Iacovache, I]]
	[[Category: Zuber, B]]		[[Category: Zuber, B]]

OCA at 03:58, 30 August 2017

OCA — Wed, 30 Aug 2017 03:58:45 GMT

←Older revision		Revision as of 03:58, 30 August 2017
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	</div>		</div>
	<div class="pdbe-citations 5jzh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jzh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aerolysin\|Aerolysin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:58, 27 July 2016

OCA — Wed, 27 Jul 2016 07:58:23 GMT

←Older revision		Revision as of 07:58, 27 July 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/AERA_AERHY AERA_AERHY]] Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximately 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis.		[[http://www.uniprot.org/uniprot/AERA_AERHY AERA_AERHY]] Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximately 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Owing to their pathogenical role and unique ability to exist both as soluble proteins and transmembrane complexes, pore-forming toxins (PFTs) have been a focus of microbiologists and structural biologists for decades. PFTs are generally secreted as water-soluble monomers and subsequently bind the membrane of target cells. Then, they assemble into circular oligomers, which undergo conformational changes that allow membrane insertion leading to pore formation and potentially cell death. Aerolysin, produced by the human pathogen Aeromonas hydrophila, is the founding member of a major PFT family found throughout all kingdoms of life. We report cryo-electron microscopy structures of three conformational intermediates and of the final aerolysin pore, jointly providing insight into the conformational changes that allow pore formation. Moreover, the structures reveal a protein fold consisting of two concentric beta-barrels, tightly kept together by hydrophobic interactions. This fold suggests a basis for the prion-like ultrastability of aerolysin pore and its stoichiometry.
		+
		+	Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process.,Iacovache I, De Carlo S, Cirauqui N, Dal Peraro M, van der Goot FG, Zuber B Nat Commun. 2016 Jul 13;7:12062. doi: 10.1038/ncomms12062. PMID:27405240<ref>PMID:27405240</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5jzh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:48, 14 July 2016

OCA — Thu, 14 Jul 2016 11:48:43 GMT

←Older revision		Revision as of 11:48, 14 July 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	{{Large structure}}
-		+	==Cryo-EM structure of aerolysin prepore==
-	~~The entry~~ 5jzh is ~~ON HOLD~~	+	<StructureSection load='5jzh' size='340' side='right' caption='[[5jzh]], [[Resolution\|resolution]] 3.90Å' scene=''>
-		+	== Structural highlights ==
-	~~Authors~~:	+	<table><tr><td colspan='2'>[[5jzh]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JZH FirstGlance]. <br>
-		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jzh OCA], [http://pdbe.org/5jzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jzh RCSB], [http://www.ebi.ac.uk/pdbsum/5jzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jzh ProSAT]</span></td></tr>
-	~~Description~~:	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	{{Large structure}}
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AERA_AERHY AERA_AERHY]] Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximately 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Iacovache, I]]
		+	[[Category: Zuber, B]]
		+	[[Category: Aerolysin]]
		+	[[Category: Concentric beta-barrel]]
		+	[[Category: Pore forming toxin]]
		+	[[Category: Toxin]]

OCA: Protected "5jzh" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:06:04 GMT

Protected "5jzh" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:06, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jzh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Jun 2016 14:06:03 GMT

New page: '''Unreleased structure''' The entry 5jzh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5jzh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]