5k01 - Revision history

OCA at 19:16, 20 September 2023

OCA — Wed, 20 Sep 2023 19:16:40 GMT

←Older revision		Revision as of 19:16, 20 September 2023
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	<StructureSection load='5k01' size='340' side='right'caption='[[5k01]], [[Resolution\|resolution]] 1.38Å' scene=''>		<StructureSection load='5k01' size='340' side='right'caption='[[5k01]], [[Resolution\|resolution]] 1.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k01]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K01 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5K01 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K01 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=6OW:2~~,~~7-DIMETHYL-3-(1H-PYRAZOL-5-YL)IMIDAZO~~[1~~,2-A]PYRIDINE'>6OW</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.383Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Comt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10116 Buffalo rat])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OW:2,7-DIMETHYL-3-(1H-PYRAZOL-5-YL)IMIDAZO[1,2-A]PYRIDINE'>6OW</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k01 OCA], [https://pdbe.org/5k01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k01 RCSB], [https://www.ebi.ac.uk/pdbsum/5k01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k01 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5k01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k01 OCA], [~~http~~://pdbe.org/5k01 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5k01 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5k01 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5k01 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.	+	[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

	==See Also==		==See Also==
Line 16:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
-	[[Category: Catechol O-methyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ehler, A~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Rodriguez-Sarmiento, R M~~]]	+	[[Category: Ehler A]]
-	[[Category: ~~Rudolph, M G~~]]	+	[[Category: Rodriguez-Sarmiento RM]]
-	[[Category: ~~Catechol]]~~	+	[[Category: Rudolph MG]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Neurotransmitter degradation]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:59, 12 June 2019

OCA — Wed, 12 Jun 2019 05:59:08 GMT

←Older revision		Revision as of 05:59, 12 June 2019
Line 1:		Line 1:

	==Crystal Structure of COMT in complex with 2,7-dimethyl-3-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridine==		==Crystal Structure of COMT in complex with 2,7-dimethyl-3-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridine==
-	<StructureSection load='5k01' size='340' side='right' caption='[[5k01]], [[Resolution\|resolution]] 1.38Å' scene=''>	+	<StructureSection load='5k01' size='340' side='right'caption='[[5k01]], [[Resolution\|resolution]] 1.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k01]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K01 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k01]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K01 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OW:2,7-DIMETHYL-3-(1H-PYRAZOL-5-YL)IMIDAZO[1,2-A]PYRIDINE'>6OW</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OW:2,7-DIMETHYL-3-(1H-PYRAZOL-5-YL)IMIDAZO[1,2-A]PYRIDINE'>6OW</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Comt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k01 OCA], [http://pdbe.org/5k01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k01 RCSB], [http://www.ebi.ac.uk/pdbsum/5k01 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k01 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k01 OCA], [http://pdbe.org/5k01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k01 RCSB], [http://www.ebi.ac.uk/pdbsum/5k01 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k01 ProSAT]</span></td></tr>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.		[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
		+
		+	==See Also==
		+	*[[Catechol O-methyltransferase 3D structures\|Catechol O-methyltransferase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Catechol O-methyltransferase]]		[[Category: Catechol O-methyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Ehler, A]]		[[Category: Ehler, A]]
-	[[Category: ~~RODRIGUEZ~~-~~SARMIENTO~~, R M]]	+	[[Category: Rodriguez-Sarmiento, R M]]
	[[Category: Rudolph, M G]]		[[Category: Rudolph, M G]]
	[[Category: Catechol]]		[[Category: Catechol]]

OCA at 21:09, 10 September 2016

OCA — Sat, 10 Sep 2016 21:09:48 GMT

←Older revision		Revision as of 21:09, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5k01 is ON HOLD~~	+	==Crystal Structure of COMT in complex with 2,7-dimethyl-3-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridine==
-		+	<StructureSection load='5k01' size='340' side='right' caption='[[5k01]], [[Resolution\|resolution]] 1.38Å' scene=''>
-	~~Authors: Ehler, A., RODRIGUEZ-SARMIENTO, R.M., Rudolph, M.G.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5k01]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K01 FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of COMT in complex with 2,7-dimethyl-3-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridine	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OW:2,7-DIMETHYL-3-(1H-PYRAZOL-5-YL)IMIDAZO[1,2-A]PYRIDINE'>6OW</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k01 OCA], [http://pdbe.org/5k01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k01 RCSB], [http://www.ebi.ac.uk/pdbsum/5k01 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k01 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Catechol O-methyltransferase]]
	[[Category: Ehler, A]]		[[Category: Ehler, A]]
-	[[Category: ~~Rodriguez~~-~~Sarmiento~~, R.M]]	+	[[Category: RODRIGUEZ-SARMIENTO, R M]]
-	[[Category: Rudolph, M.G]]	+	[[Category: Rudolph, M G]]
		+	[[Category: Catechol]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Neurotransmitter degradation]]
		+	[[Category: Transferase]]

OCA: Protected "5k01" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:07:24 GMT

Protected "5k01" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:07, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5k01 is ON HOLD Authors: Ehler, A., RODRIGUEZ-SARMIENTO, R.M., Rudolph, M.G. Description: Crystal Structure of COMT in complex with 2,7-dimethyl-3-...

OCA — Wed, 01 Jun 2016 14:07:22 GMT

New page: '''Unreleased structure''' The entry 5k01 is ON HOLD Authors: Ehler, A., RODRIGUEZ-SARMIENTO, R.M., Rudolph, M.G. Description: Crystal Structure of COMT in complex with 2,7-dimethyl-3-...

New page

'''Unreleased structure'''

The entry 5k01 is ON HOLD

Authors: Ehler, A., RODRIGUEZ-SARMIENTO, R.M., Rudolph, M.G.

Description: Crystal Structure of COMT in complex with 2,7-dimethyl-3-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridine
[[Category: Unreleased Structures]]
[[Category: Ehler, A]]
[[Category: Rodriguez-Sarmiento, R.M]]
[[Category: Rudolph, M.G]]