5k18 - Revision history

OCA at 14:32, 29 November 2023

OCA — Wed, 29 Nov 2023 14:32:22 GMT

←Older revision		Revision as of 14:32, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5k18]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_WO-1 Candida albicans WO-1] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K18 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5k18]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_WO-1 Candida albicans WO-1] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K18 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.73Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k18 OCA], [https://pdbe.org/5k18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k18 RCSB], [https://www.ebi.ac.uk/pdbsum/5k18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k18 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k18 OCA], [https://pdbe.org/5k18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k18 RCSB], [https://www.ebi.ac.uk/pdbsum/5k18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k18 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:34, 7 April 2023

OCA — Fri, 07 Apr 2023 06:34:15 GMT

←Older revision		Revision as of 06:34, 7 April 2023
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	<StructureSection load='5k18' size='340' side='right'caption='[[5k18]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='5k18' size='340' side='right'caption='[[5k18]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k18]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Canaw Canaw~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K18 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5K18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k18]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_WO-1 Candida albicans WO-1] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K18 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~ACY~~:~~ACETIC~~+~~ACID~~'>~~ACY~~</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5k04\|5k04]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k18 OCA], [https://pdbe.org/5k18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k18 RCSB], [https://www.ebi.ac.uk/pdbsum/5k18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k18 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAWG_01335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294748 CANAW]), CAWG_00748 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294748 CANAW])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k18 OCA], [~~http~~://pdbe.org/5k18 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5k18 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5k18 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5k18 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C4YFL7_CANAW C4YFL7_CANAW]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canaw~~]]	+	[[Category: Candida albicans WO-1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cai, Y]]	+	[[Category: Synthetic construct]]
-	[[Category: Han, A]]	+	[[Category: Cai Y]]
-	[[Category: Hong, H]]	+	[[Category: Han A]]
-	[[Category: Zhang, S]]	+	[[Category: Hong H]]
-	~~[[Category: N-terminal acetyltransferase complex]]~~	+	[[Category: Zhang S]]
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 12:07, 25 December 2019

OCA — Wed, 25 Dec 2019 12:07:50 GMT

←Older revision		Revision as of 12:07, 25 December 2019
Line 1:		Line 1:

	==The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor==		==The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor==
-	<StructureSection load='5k18' size='340' side='right' caption='[[5k18]], [[Resolution\|resolution]] 2.73Å' scene=''>	+	<StructureSection load='5k18' size='340' side='right'caption='[[5k18]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k18]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k18]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canaw Canaw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K18 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5k04\|5k04]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5k04\|5k04]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAWG_01335 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294748 CANAW]), CAWG_00748 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294748 CANAW])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k18 OCA], [http://pdbe.org/5k18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k18 RCSB], [http://www.ebi.ac.uk/pdbsum/5k18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k18 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k18 OCA], [http://pdbe.org/5k18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k18 RCSB], [http://www.ebi.ac.uk/pdbsum/5k18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k18 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Canaw]]
		+	[[Category: Large Structures]]
	[[Category: Cai, Y]]		[[Category: Cai, Y]]
	[[Category: Han, A]]		[[Category: Han, A]]

OCA at 12:59, 19 April 2017

OCA — Wed, 19 Apr 2017 12:59:04 GMT

←Older revision		Revision as of 12:59, 19 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5k18 is ~~ON HOLD until Paper~~ Publication	+	==The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor==
		+	<StructureSection load='5k18' size='340' side='right' caption='[[5k18]], [[Resolution\|resolution]] 2.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5k18]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K18 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5k04\|5k04]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k18 OCA], [http://pdbe.org/5k18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k18 RCSB], [http://www.ebi.ac.uk/pdbsum/5k18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k18 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The NatB N-terminal acetyltransferase specifically acetylates the N-terminal group of substrate protein peptides starting with Met-Asp/Glu/Asn/Gln. How NatB recognizes and acetylates these substrates remains unknown. Here, we report crystal structures of a NatB holoenzyme from Candida albicans in the presence of its co-factor CoA and substrate peptides. The auxiliary subunit Naa25 of NatB forms a horseshoe-like deck to hold specifically its catalytic subunit Naa20. The first two amino acids Met and Asp of a substrate peptide mediate the major interactions with the active site in the Naa20 subunit. The hydrogen bonds between the substrate Asp and pocket residues of Naa20 are essential to determine the NatB substrate specificity. Moreover, a hydrogen bond between the amino group of the substrate Met and a carbonyl group in the Naa20 active site directly anchors the substrate toward acetyl-CoA. Together, these structures define a unique molecular mechanism of specific N-terminal acetylation acted by NatB.

-	~~Authors: Hong~~, H., Cai, Y., Zhang, S., ~~Han~~, A.	+	Molecular Basis of Substrate Specific Acetylation by N-Terminal Acetyltransferase NatB.,Hong H, Cai Y, Zhang S, Ding H, Wang H, Han A Structure. 2017 Apr 4;25(4):641-649.e3. doi: 10.1016/j.str.2017.03.003. PMID:28380339<ref>PMID:28380339</ref>

-	~~Description: The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Han, A]]~~	+	<div class="pdbe-citations 5k18" style="background-color:#fffaf0;"></div>
-	~~[[Category: Zhang, S]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Cai, Y]]		[[Category: Cai, Y]]
		+	[[Category: Han, A]]
	[[Category: Hong, H]]		[[Category: Hong, H]]
		+	[[Category: Zhang, S]]
		+	[[Category: N-terminal acetyltransferase complex]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 10:07, 9 March 2017

OCA — Thu, 09 Mar 2017 10:07:29 GMT

←Older revision		Revision as of 10:07, 9 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5k18 is ON HOLD	+	The entry 5k18 is ON HOLD until Paper Publication

	Authors: Hong, H., Cai, Y., Zhang, S., Han, A.		Authors: Hong, H., Cai, Y., Zhang, S., Han, A.
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	Description: The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor		Description: The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Han, A]]
	[[Category: Zhang, S]]		[[Category: Zhang, S]]
	[[Category: Cai, Y]]		[[Category: Cai, Y]]
-	[[Category: Han, A]]
	[[Category: Hong, H]]		[[Category: Hong, H]]

OCA: Protected "5k18" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:10:42 GMT

Protected "5k18" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:10, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5k18 is ON HOLD Authors: Hong, H., Cai, Y., Zhang, S., Han, A. Description: The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor [[Cat...

OCA — Wed, 01 Jun 2016 14:10:41 GMT

New page: '''Unreleased structure''' The entry 5k18 is ON HOLD Authors: Hong, H., Cai, Y., Zhang, S., Han, A. Description: The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor [[Cat...

New page

'''Unreleased structure'''

The entry 5k18 is ON HOLD

Authors: Hong, H., Cai, Y., Zhang, S., Han, A.

Description: The NatB Acetyltransferase Complex Bound To bisubstrate inhibitor
[[Category: Unreleased Structures]]
[[Category: Zhang, S]]
[[Category: Cai, Y]]
[[Category: Han, A]]
[[Category: Hong, H]]