5k19 - Revision history

OCA at 19:17, 20 September 2023

OCA — Wed, 20 Sep 2023 19:17:45 GMT

←Older revision		Revision as of 19:17, 20 September 2023
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	<StructureSection load='5k19' size='340' side='right'caption='[[5k19]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5k19' size='340' side='right'caption='[[5k19]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k19]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K19 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5K19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k19]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K19 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.602Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5k1c\|5k1c]], [[5k1a\|5k1a]], [[5k1b\|5k1b]], [[5k16\|5k16]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">WDR20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k19 OCA], [https://pdbe.org/5k19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k19 RCSB], [https://www.ebi.ac.uk/pdbsum/5k19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k19 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k19 OCA], [~~http~~://pdbe.org/5k19 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5k19 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5k19 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5k19 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/WDR20_HUMAN WDR20_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[WD ~~repeat~~-~~containing~~ protein\|WD ~~repeat~~-~~containing~~ protein]]	+	*[[WD-repeat protein 3D structures\|WD-repeat protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andrea~~, A D.D~~]]	+	[[Category: D'Andrea AD]]
-	[[Category: Li, H]]	+	[[Category: Li H]]
-	[[Category: Zheng, N]]	+	[[Category: Zheng N]]
-	~~[[Category: Unknown function]]~~	+
-	~~[[Category: Wdr20~~]]	+

OCA at 16:24, 20 November 2019

OCA — Wed, 20 Nov 2019 16:24:10 GMT

←Older revision		Revision as of 16:24, 20 November 2019
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	==Crystal structure of WD repeat-containing protein 20==		==Crystal structure of WD repeat-containing protein 20==
-	<StructureSection load='5k19' size='340' side='right' caption='[[5k19]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5k19' size='340' side='right'caption='[[5k19]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5k19]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5k19]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K19 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5k19" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5k19" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[WD repeat-containing protein\|WD repeat-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Andrea, A D.D]]		[[Category: Andrea, A D.D]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA at 18:07, 15 November 2017

OCA — Wed, 15 Nov 2017 18:07:05 GMT

←Older revision		Revision as of 18:07, 15 November 2017
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	<StructureSection load='5k19' size='340' side='right' caption='[[5k19]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5k19' size='340' side='right' caption='[[5k19]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k19]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k19]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K19 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5k1c\|5k1c]], [[5k1a\|5k1a]], [[5k1b\|5k1b]], [[5k16\|5k16]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5k1c\|5k1c]], [[5k1a\|5k1a]], [[5k1b\|5k1b]], [[5k16\|5k16]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">WDR20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k19 OCA], [http://pdbe.org/5k19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k19 RCSB], [http://www.ebi.ac.uk/pdbsum/5k19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k19 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k19 OCA], [http://pdbe.org/5k19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k19 RCSB], [http://www.ebi.ac.uk/pdbsum/5k19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k19 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Andrea, A D.D]]		[[Category: Andrea, A D.D]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA at 15:14, 26 July 2016

OCA — Tue, 26 Jul 2016 15:14:20 GMT

←Older revision		Revision as of 15:14, 26 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5k19 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of WD repeat-containing protein 20==
		+	<StructureSection load='5k19' size='340' side='right' caption='[[5k19]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5k19]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K19 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5k1c\|5k1c]], [[5k1a\|5k1a]], [[5k1b\|5k1b]], [[5k16\|5k16]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k19 OCA], [http://pdbe.org/5k19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k19 RCSB], [http://www.ebi.ac.uk/pdbsum/5k19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k19 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ubiquitin-specific proteases (USPs) constitute the largest family of deubiquitinating enzymes, whose catalytic competency is often modulated by their binding partners through unknown mechanisms. Here we report on a series of crystallographic and biochemical analyses of an evolutionarily conserved deubiquitinase, USP12, which is activated by two beta-propeller proteins, UAF1 and WDR20. Our structures reveal that UAF1 and WDR20 interact with USP12 at two distinct sites far from its catalytic center. Without increasing the substrate affinity of USP12, the two beta-propeller proteins potentiate the enzyme through different allosteric mechanisms. UAF1 docks at the distal end of the USP12 Fingers domain and induces a cascade of structural changes that reach a critical ubiquitin-contacting loop adjacent to the catalytic cleft. By contrast, WDR20 anchors at the base of this loop and remotely modulates the catalytic center of the enzyme. Our results provide a mechanistic example for allosteric activation of USPs by their regulatory partners.

-	~~Authors:~~ Li, H., D'Andrea, A.D., ~~Zheng, N~~.	+	Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.,Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D'Andrea AD, Zheng N Mol Cell. 2016 Jul 21;63(2):249-60. doi: 10.1016/j.molcel.2016.05.031. Epub 2016 , Jun 30. PMID:27373336<ref>PMID:27373336</ref>

-	~~Description: Crystal structure~~ of ~~WD repeat-containing protein 20~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: D'Andrea, A.D]]	+	<div class="pdbe-citations 5k19" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Andrea, A D.D]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Zheng, N]]		[[Category: Zheng, N]]
		+	[[Category: Unknown function]]
		+	[[Category: Wdr20]]

OCA at 13:20, 20 June 2016

OCA — Mon, 20 Jun 2016 13:20:09 GMT

←Older revision		Revision as of 13:20, 20 June 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5k19 is ON HOLD	+	The entry 5k19 is ON HOLD until Paper Publication

	Authors: Li, H., D'Andrea, A.D., Zheng, N.		Authors: Li, H., D'Andrea, A.D., Zheng, N.

OCA: Protected "5k19" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:10:45 GMT

Protected "5k19" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:10, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5k19 is ON HOLD Authors: Li, H., D'Andrea, A.D., Zheng, N. Description: Crystal structure of WD repeat-containing protein 20 [[Category: Unreleased...

OCA — Wed, 01 Jun 2016 14:10:43 GMT

New page: '''Unreleased structure''' The entry 5k19 is ON HOLD Authors: Li, H., D'Andrea, A.D., Zheng, N. Description: Crystal structure of WD repeat-containing protein 20 [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 5k19 is ON HOLD

Authors: Li, H., D'Andrea, A.D., Zheng, N.

Description: Crystal structure of WD repeat-containing protein 20
[[Category: Unreleased Structures]]
[[Category: D'Andrea, A.D]]
[[Category: Li, H]]
[[Category: Zheng, N]]