5k79 - Revision history

OCA at 09:53, 27 September 2023

OCA — Wed, 27 Sep 2023 09:53:01 GMT

←Older revision		Revision as of 09:53, 27 September 2023
Line 3:		Line 3:
	<StructureSection load='5k79' size='340' side='right'caption='[[5k79]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5k79' size='340' side='right'caption='[[5k79]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k79]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cyanothece_pcc_7424 Cyanothece pcc~~ 7424]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K79 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5K79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeothece_citriformis_PCC_7424 Gloeothece citriformis PCC 7424]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K79 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PCC7424_1905 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=65393 Cyanothece PCC 7424]~~)</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [~~http~~://pdbe.org/5k79 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [https://pdbe.org/5k79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [https://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B7KDN5_GLOC7 B7KDN5_GLOC7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cyanothece pcc~~ 7424]]	+	[[Category: Gloeothece citriformis PCC 7424]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aiken, C]]	+	[[Category: Aiken C]]
-	[[Category: Basu, R]]	+	[[Category: Basu R]]
-	[[Category: Calnan, C]]	+	[[Category: Calnan C]]
-	[[Category: Furey, W]]	+	[[Category: Furey W]]
-	[[Category: Gronenborn~~, A M~~]]	+	[[Category: Gronenborn AM]]
-	[[Category: Matei, E]]	+	[[Category: Matei E]]
-	[[Category: Shi, J]]	+	[[Category: Shi J]]
-	~~[[Category: Antiviral protein]]~~	+
-	~~[[Category: Hiv-inactivating]]~~	+
-	~~[[Category: Oligosaccharide]]~~	+
-	~~[[Category: Sugar binding lectin~~]]	+

OCA at 12:08, 25 December 2019

OCA — Wed, 25 Dec 2019 12:08:26 GMT

←Older revision		Revision as of 12:08, 25 December 2019
Line 1:		Line 1:

	==Structure and anti-HIV activity of CYT-CVNH, a new cyanovirin-n homolog==		==Structure and anti-HIV activity of CYT-CVNH, a new cyanovirin-n homolog==
-	<StructureSection load='5k79' size='340' side='right' caption='[[5k79]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5k79' size='340' side='right'caption='[[5k79]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cyap7 Cyap7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyanothece_pcc_7424 Cyanothece pcc 7424]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K79 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7424_1905 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=65393 ~~CYAP7~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7424_1905 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=65393 Cyanothece PCC 7424])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [http://pdbe.org/5k79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [http://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [http://pdbe.org/5k79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [http://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cyap7~~]]	+	[[Category: Cyanothece pcc 7424]]
		+	[[Category: Large Structures]]
	[[Category: Aiken, C]]		[[Category: Aiken, C]]
	[[Category: Basu, R]]		[[Category: Basu, R]]

OCA at 12:58, 6 November 2017

OCA — Mon, 06 Nov 2017 12:58:10 GMT

←Older revision		Revision as of 12:58, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='5k79' size='340' side='right' caption='[[5k79]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5k79' size='340' side='right' caption='[[5k79]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k79]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K79 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k79]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyap7 Cyap7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K79 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCC7424_1905 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=65393 CYAP7])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [http://pdbe.org/5k79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [http://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [http://pdbe.org/5k79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [http://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cyap7]]
	[[Category: Aiken, C]]		[[Category: Aiken, C]]
	[[Category: Basu, R]]		[[Category: Basu, R]]

OCA at 08:11, 27 July 2016

OCA — Wed, 27 Jul 2016 08:11:06 GMT

←Older revision		Revision as of 08:11, 27 July 2016
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [http://pdbe.org/5k79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [http://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [http://pdbe.org/5k79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [http://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The HIV-1 envelope glycoprotein gp120 is heavily glycosylated and bears numerous high-mannose sugars. These sugars can serve as targets for HIV-inactivating compounds, such as antibodies and lectins, which bind to the glycans and interfere with viral entry into the target cell. We determined the 1.6 A X-ray structure of Cyt-CVNH, a recently identified lectin from the cyanobacterium Cyanothece7424, and elucidated its glycan specificity by NMR. The Cyt-CVNH structure and glycan recognition profile are similar to those of other CVNH proteins, with each domain specifically binding to Mana(1-2)Mana units on the D1 and D3 arms of high-mannose glycans. However, in contrast to CV-N, no cross-linking and precipitation of the cross-linked species in solutions was observed upon Man-9 binding, allowing for the first time to investigate the interaction of Man-9 with a member of the CVNH family by NMR. HIV assays showed that Cyt-CVNH is able to inhibit HIV-1 with ~ 4-fold higher potency than CV-NP51G, a stabilized version of wild type CV-N. Therefore, Cyt-CVNH may qualify as a valuable lectin for potential microbicidal use.
		+
		+	Structure and Glycan Binding of a New Cyanovirin-N Homolog.,Matei E, Basu R, Furey W, Shi J, Calnan C, Aiken C, Gronenborn AM J Biol Chem. 2016 Jul 7. pii: jbc.M116.740415. PMID:27402833<ref>PMID:27402833</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5k79" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:38, 26 July 2016

OCA — Tue, 26 Jul 2016 15:38:17 GMT

←Older revision		Revision as of 15:38, 26 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5k79 is ~~ON HOLD until Paper Publication~~	+	==Structure and anti-HIV activity of CYT-CVNH, a new cyanovirin-n homolog==
-		+	<StructureSection load='5k79' size='340' side='right' caption='[[5k79]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5k79]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K79 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k79 OCA], [http://pdbe.org/5k79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k79 RCSB], [http://www.ebi.ac.uk/pdbsum/5k79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k79 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aiken, C]]
		+	[[Category: Basu, R]]
		+	[[Category: Calnan, C]]
		+	[[Category: Furey, W]]
		+	[[Category: Gronenborn, A M]]
		+	[[Category: Matei, E]]
		+	[[Category: Shi, J]]
		+	[[Category: Antiviral protein]]
		+	[[Category: Hiv-inactivating]]
		+	[[Category: Oligosaccharide]]
		+	[[Category: Sugar binding lectin]]

OCA: Protected "5k79" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:25:00 GMT

Protected "5k79" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:25, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5k79 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Jun 2016 14:24:59 GMT

New page: '''Unreleased structure''' The entry 5k79 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5k79 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]