5k89 - Revision history

OCA at 09:54, 27 September 2023

OCA — Wed, 27 Sep 2023 09:54:23 GMT

←Older revision		Revision as of 09:54, 27 September 2023
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	<StructureSection load='5k89' size='340' side='right'caption='[[5k89]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='5k89' size='340' side='right'caption='[[5k89]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5K89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K89 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~>, ~~<scene name='pdbligand=TRS:~~2~~-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.249Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~S100A1, S100A ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5k89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k89 OCA], [~~http~~://pdbe.org/5k89 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5k89 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5k89 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5k89 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k89 OCA], [https://pdbe.org/5k89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k89 RCSB], [https://www.ebi.ac.uk/pdbsum/5k89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k89 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.	+	[https://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[S100 ~~protein~~\|S100 ~~protein~~]]	+	*[[S100 proteins 3D structures\|S100 proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aligholizadeh, E]]	+	[[Category: Aligholizadeh E]]
-	[[Category: McKnight~~, L E~~]]	+	[[Category: McKnight LE]]
-	[[Category: Melville, Z]]	+	[[Category: Melville Z]]
-	[[Category: Pozharski, E]]	+	[[Category: Pozharski E]]
-	[[Category: Weber, D]]	+	[[Category: Weber D]]
-	[[Category: Weber~~, D J]]~~	+	[[Category: Weber DJ]]
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: S100]]~~	+
-	~~[[Category: S100a1~~]]	+

OCA at 09:12, 4 December 2019

OCA — Wed, 04 Dec 2019 09:12:56 GMT

←Older revision		Revision as of 09:12, 4 December 2019
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	==Crystal Structure of Human Calcium-Bound S100A1==		==Crystal Structure of Human Calcium-Bound S100A1==
-	<StructureSection load='5k89' size='340' side='right' caption='[[5k89]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='5k89' size='340' side='right'caption='[[5k89]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K89 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K89 FirstGlance]. <br>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aligholizadeh, E]]		[[Category: Aligholizadeh, E]]
	[[Category: McKnight, L E]]		[[Category: McKnight, L E]]

OCA at 05:45, 16 May 2018

OCA — Wed, 16 May 2018 05:45:27 GMT

←Older revision		Revision as of 05:45, 16 May 2018
Line 3:		Line 3:
	<StructureSection load='5k89' size='340' side='right' caption='[[5k89]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='5k89' size='340' side='right' caption='[[5k89]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K89 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S100A1, S100A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k89 OCA], [http://pdbe.org/5k89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k89 RCSB], [http://www.ebi.ac.uk/pdbsum/5k89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k89 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k89 OCA], [http://pdbe.org/5k89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k89 RCSB], [http://www.ebi.ac.uk/pdbsum/5k89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k89 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.		[[http://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S100A1 is a member of the S100 family of Ca(2+)-binding proteins and regulates several cellular processes, including those involved in Ca(2+) signaling and cardiac and skeletal muscle function. In Alzheimer's disease, brain S100A1 is overexpressed and gives rise to disease pathologies, making it a potential therapeutic target. The 2.25 A resolution crystal structure of Ca(2+)-S100A1 is solved here and is compared with the structures of other S100 proteins, most notably S100B, which is a highly homologous S100-family member that is implicated in the progression of malignant melanoma. The observed structural differences in S100A1 versus S100B provide insights regarding target protein-binding specificity and for targeting these two S100 proteins in human diseases using structure-based drug-design approaches.
		+
		+	X-ray crystal structure of human calcium-bound S100A1.,Melville Z, Aligholizadeh E, McKnight LE, Weber DJ, Pozharski E, Weber DJ Acta Crystallogr F Struct Biol Commun. 2017 Apr 1;73(Pt 4):215-221. doi:, 10.1107/S2053230X17003983. Epub 2017 Mar 22. PMID:28368280<ref>PMID:28368280</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5k89" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[S100 protein\|S100 protein]]		*[[S100 protein\|S100 protein]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Aligholizadeh, E]]		[[Category: Aligholizadeh, E]]
	[[Category: McKnight, L E]]		[[Category: McKnight, L E]]

OCA at 07:28, 6 October 2017

OCA — Fri, 06 Oct 2017 07:28:45 GMT

←Older revision		Revision as of 07:28, 6 October 2017
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.		[[http://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
		+
		+	==See Also==
		+	*[[S100 protein\|S100 protein]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:43, 12 April 2017

OCA — Wed, 12 Apr 2017 11:43:44 GMT

←Older revision		Revision as of 11:43, 12 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5k89 ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of Human Calcium-Bound S100A1==
-		+	<StructureSection load='5k89' size='340' side='right' caption='[[5k89]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~Authors~~: ~~Melville, Z~~., ~~Aligholizadeh~~, E., ~~McKnight, L~~.E., ~~Weber~~, D., ~~Pozharski, E~~., ~~Weber, D~~.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5k89]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K89 FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure~~ of ~~Human Calcium~~-~~Bound S100A1~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k89 OCA], [http://pdbe.org/5k89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k89 RCSB], [http://www.ebi.ac.uk/pdbsum/5k89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k89 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/S10A1_HUMAN S10A1_HUMAN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aligholizadeh, E]]
		+	[[Category: McKnight, L E]]
	[[Category: Melville, Z]]		[[Category: Melville, Z]]
	[[Category: Pozharski, E]]		[[Category: Pozharski, E]]
-	[[Category: Mcknight, L.E]]
	[[Category: Weber, D]]		[[Category: Weber, D]]
-	[[Category: Weber, D.J]]	+	[[Category: Weber, D J]]
-	[[Category: ~~Aligholizadeh, E~~]]	+	[[Category: Calcium]]
		+	[[Category: Metal binding protein]]
		+	[[Category: S100]]
		+	[[Category: S100a1]]

OCA at 12:12, 2 January 2017

OCA — Mon, 02 Jan 2017 12:12:46 GMT

←Older revision		Revision as of 12:12, 2 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5k89 is ON HOLD	+	The entry 5k89 is ON HOLD until Paper Publication

	Authors: Melville, Z., Aligholizadeh, E., McKnight, L.E., Weber, D., Pozharski, E., Weber, D.J.		Authors: Melville, Z., Aligholizadeh, E., McKnight, L.E., Weber, D., Pozharski, E., Weber, D.J.

OCA at 17:32, 22 December 2016

OCA — Thu, 22 Dec 2016 17:32:39 GMT

←Older revision		Revision as of 17:32, 22 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5k89 is ON HOLD ~~until Paper Publication~~	+	The entry 5k89 is ON HOLD

	Authors: Melville, Z., Aligholizadeh, E., McKnight, L.E., Weber, D., Pozharski, E., Weber, D.J.		Authors: Melville, Z., Aligholizadeh, E., McKnight, L.E., Weber, D., Pozharski, E., Weber, D.J.

OCA at 13:37, 19 October 2016

OCA — Wed, 19 Oct 2016 13:37:00 GMT

←Older revision		Revision as of 13:37, 19 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5k89 is ON HOLD	+	The entry 5k89 is ON HOLD until Paper Publication

-	Authors: Melville, Z., Aligholizadeh, E, McKnight, L.E., Weber, D, Pozharski, E, Weber, D.J.	+	Authors: Melville, Z., Aligholizadeh, E., McKnight, L.E., Weber, D., Pozharski, E., Weber, D.J.

	Description: Crystal Structure of Human Calcium-Bound S100A1		Description: Crystal Structure of Human Calcium-Bound S100A1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Melville, Z]]		[[Category: Melville, Z]]
-	[[Category: ~~Weber, D,~~ Pozharski, E, Weber, D.J]]	+	[[Category: Pozharski, E]]
-	[[Category: Aligholizadeh, ~~E, Mcknight, L.~~E]]	+	[[Category: Mcknight, L.E]]
		+	[[Category: Weber, D]]
		+	[[Category: Weber, D.J]]
		+	[[Category: Aligholizadeh, E]]

OCA at 10:27, 21 September 2016

OCA — Wed, 21 Sep 2016 10:27:58 GMT

←Older revision		Revision as of 10:27, 21 September 2016
Line 3:		Line 3:
	The entry 5k89 is ON HOLD		The entry 5k89 is ON HOLD

-	Authors: Melville, Z., McKnight, L.E., Weber, D.J.	+	Authors: Melville, Z., Aligholizadeh, E, McKnight, L.E., Weber, D, Pozharski, E, Weber, D.J.

-	Description: Crystal Structure of Calcium-~~loaded Human~~ S100A1	+	Description: Crystal Structure of Human Calcium-Bound S100A1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Melville, Z]]		[[Category: Melville, Z]]
-	[[Category: ~~Mcknight~~, L.E]]	+	[[Category: Weber, D, Pozharski, E, Weber, D.J]]
-	[[Category: ~~Weber~~, D.J]]	+	[[Category: Aligholizadeh, E, Mcknight, L.E]]

OCA: Protected "5k89" [edit=sysop:move=sysop]

OCA — Mon, 20 Jun 2016 13:33:00 GMT

Protected "5k89" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:33, 20 June 2016