5ke2 - Revision history

OCA at 09:59, 27 September 2023

OCA — Wed, 27 Sep 2023 09:59:02 GMT

←Older revision		Revision as of 09:59, 27 September 2023
Line 3:		Line 3:
	<StructureSection load='5ke2' size='340' side='right'caption='[[5ke2]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='5ke2' size='340' side='right'caption='[[5ke2]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ke2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KE2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KE2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ke2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KE2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6S4:(3~{S})-~{N}-~{TERT}-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE'>6S4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.56Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SETDB1, KIAA0067, KMT1E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6S4:(3~{S})-~{N}-~{TERT}-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE'>6S4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ke2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ke2 OCA], [~~http~~://pdbe.org/5ke2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ke2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ke2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ke2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ke2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ke2 OCA], [https://pdbe.org/5ke2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ke2 RCSB], [https://www.ebi.ac.uk/pdbsum/5ke2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ke2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>	+	[https://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Brown~~, P J~~]]	+	[[Category: Brown PJ]]
-	[[Category: Dobrovetsky, E]]	+	[[Category: Dobrovetsky E]]
-	[[Category: Dong, A]]	+	[[Category: Dong A]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: Iqbal, A]]	+	[[Category: Iqbal A]]
-	[[Category: Mader, P]]	+	[[Category: Mader P]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Walker JR]]
-	[[Category: Walker~~, J R]]~~	+
-	~~[[Category: Setdb1]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Tudor domain~~]]	+

OCA at 15:23, 8 July 2020

OCA — Wed, 08 Jul 2020 15:23:43 GMT

←Older revision		Revision as of 15:23, 8 July 2020
Line 1:		Line 1:

	==Crystal structure of SETDB1 Tudor domain in complex with inhibitor XST06472A==		==Crystal structure of SETDB1 Tudor domain in complex with inhibitor XST06472A==
-	<StructureSection load='5ke2' size='340' side='right' caption='[[5ke2]], [[Resolution\|resolution]] 1.56Å' scene=''>	+	<StructureSection load='5ke2' size='340' side='right'caption='[[5ke2]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ke2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KE2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KE2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ke2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KE2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KE2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6S4:(3~{S})-~{N}-~{TERT}-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE'>6S4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6S4:(3~{S})-~{N}-~{TERT}-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE'>6S4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ke2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ke2 OCA], [http://pdbe.org/5ke2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ke2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ke2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ke2 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SETDB1, KIAA0067, KMT1E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ke2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ke2 OCA], [http://pdbe.org/5ke2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ke2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ke2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ke2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>		[[http://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
		+
		+	==See Also==
		+	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 11:50, 14 July 2016

OCA — Thu, 14 Jul 2016 11:50:21 GMT

←Older revision		Revision as of 11:50, 14 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ke2 ~~is ON HOLD~~	+	==Crystal structure of SETDB1 Tudor domain in complex with inhibitor XST06472A==
-		+	<StructureSection load='5ke2' size='340' side='right' caption='[[5ke2]], [[Resolution\|resolution]] 1.56Å' scene=''>
-	~~Authors~~: ~~Dong, A~~.~~, Iqbal, A~~., ~~Mader~~, P., ~~Dobrovetsky~~, E., ~~Twalker~~, J.R.~~, Bountra, C~~., ~~Arrowsmith, C~~.H., ~~Edwards~~, A.M., ~~Brown, P~~.J., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ke2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KE2 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~SETDB1 Tudor domain~~ in complex with ~~fragment MRT0181a~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6S4:(3~{S})-~{N}-~{TERT}-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE'>6S4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ke2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ke2 OCA], [http://pdbe.org/5ke2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ke2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ke2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ke2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Brown, P J]]
		+	[[Category: Dobrovetsky, E]]
	[[Category: Dong, A]]		[[Category: Dong, A]]
-	[[Category: ~~Dobrovetsky~~, E]]	+	[[Category: Edwards, A M]]
-	[[Category: ~~Twalker~~, ~~J.R~~]]	+	[[Category: Iqbal, A]]
	[[Category: Mader, P]]		[[Category: Mader, P]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Structural genomic]]
-	[[Category: ~~Arrowsmith~~, ~~C.H~~]]	+	[[Category: Walker, J R]]
-	[[Category: ~~Iqbal, A~~]]	+	[[Category: Setdb1]]
-	[[Category: ~~Brown, P.J~~]]	+	[[Category: Sgc]]
-	[[Category: ~~Edwards, A.M~~]]	+	[[Category: Transcription]]
-	[[Category: ~~Structural Genomics Consortium (Sgc)~~]]	+	[[Category: Tudor domain]]

OCA at 21:28, 23 June 2016

OCA — Thu, 23 Jun 2016 21:28:17 GMT

←Older revision		Revision as of 21:28, 23 June 2016
Line 3:		Line 3:
	The entry 5ke2 is ON HOLD		The entry 5ke2 is ON HOLD

-	Authors: ~~DONG~~, A., ~~IQBAL~~, A., ~~MADER~~, P., ~~DOBROVETSKY~~, E., ~~TWALKER~~, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., ~~BROWN~~, P.J., Structural Genomics Consortium (SGC)	+	Authors: Dong, A., Iqbal, A., Mader, P., Dobrovetsky, E., Twalker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)

	Description: Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a		Description: Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a

OCA: Protected "5ke2" [edit=sysop:move=sysop]

OCA — Mon, 20 Jun 2016 13:48:49 GMT

Protected "5ke2" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:48, 20 June 2016

OCA: New page: '''Unreleased structure''' The entry 5ke2 is ON HOLD Authors: DONG, A., IQBAL, A., MADER, P., DOBROVETSKY, E., TWALKER, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., ...

OCA — Mon, 20 Jun 2016 13:48:48 GMT

New page: '''Unreleased structure''' The entry 5ke2 is ON HOLD Authors: DONG, A., IQBAL, A., MADER, P., DOBROVETSKY, E., TWALKER, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., ...

New page

'''Unreleased structure'''

The entry 5ke2 is ON HOLD

Authors: DONG, A., IQBAL, A., MADER, P., DOBROVETSKY, E., TWALKER, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., Structural Genomics Consortium (SGC)

Description: Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a
[[Category: Unreleased Structures]]
[[Category: Dong, A]]
[[Category: Dobrovetsky, E]]
[[Category: Twalker, J.R]]
[[Category: Mader, P]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Iqbal, A]]
[[Category: Brown, P.J]]
[[Category: Edwards, A.M]]
[[Category: Structural Genomics Consortium (Sgc)]]