5kep - Revision history

OCA at 06:34, 7 April 2023

OCA — Fri, 07 Apr 2023 06:34:21 GMT

←Older revision		Revision as of 06:34, 7 April 2023
Line 3:		Line 3:
	<SX load='5kep' size='340' side='right' viewer='molstar' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>		<SX load='5kep' size='340' side='right' viewer='molstar' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hpv16 Hpv16~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KEP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KEP FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5keq\|5keq]], [[5key\|5key]], [[5kgb\|5kgb]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kep OCA], [https://pdbe.org/5kep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kep RCSB], [https://www.ebi.ac.uk/pdbsum/5kep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kep ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333760 HPV16])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kep OCA], [~~http~~://pdbe.org/5kep PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kep RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kep PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kep ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref>	+	[https://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[~~Major capsid protein L1~~\|~~Major capsid protein L1~~]]	+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Hpv16~~]]	+	[[Category: Human papillomavirus type 16]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ashley~~, R E~~]]	+	[[Category: Ashley RE]]
-	[[Category: Brendle~~, S A~~]]	+	[[Category: Brendle SA]]
-	[[Category: Bywaters~~, S M~~]]	+	[[Category: Bywaters SM]]
-	[[Category: Christensen~~, N D~~]]	+	[[Category: Christensen ND]]
-	[[Category: Conway~~, J F~~]]	+	[[Category: Conway JF]]
-	[[Category: Guan, J]]	+	[[Category: Guan J]]
-	[[Category: Hafenstein, S]]	+	[[Category: Hafenstein S]]
-	[[Category: Makhov~~, A M]]~~	+	[[Category: Makhov AM]]
-	~~[[Category: Asymmetric unit]]~~	+
-	~~[[Category: L1 protein]]~~	+
-	~~[[Category: Virus like particle~~]]	+

OCA at 20:31, 10 April 2020

OCA — Fri, 10 Apr 2020 20:31:01 GMT

←Older revision		Revision as of 20:31, 10 April 2020
Line 3:		Line 3:
	<SX load='5kep' size='340' side='right' viewer='molstar' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>		<SX load='5kep' size='340' side='right' viewer='molstar' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv16 Hpv16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KEP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv16 Hpv16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KEP FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5keq\|5keq]], [[5key\|5key]], [[5kgb\|5kgb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5keq\|5keq]], [[5key\|5key]], [[5kgb\|5kgb]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333760 HPV16])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333760 HPV16])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kep OCA], [http://pdbe.org/5kep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kep RCSB], [http://www.ebi.ac.uk/pdbsum/5kep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kep ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kep OCA], [http://pdbe.org/5kep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kep RCSB], [http://www.ebi.ac.uk/pdbsum/5kep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kep ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:33, 5 March 2020

OCA — Thu, 05 Mar 2020 04:33:13 GMT

←Older revision		Revision as of 04:33, 5 March 2020
Line 1:		Line 1:

	==High resolution cryo-EM maps of Human Papillomavirus 16 reveal L2 location and heparin-induced conformational changes==		==High resolution cryo-EM maps of Human Papillomavirus 16 reveal L2 location and heparin-induced conformational changes==
-	<~~StructureSection~~ load='5kep' size='340' side='right' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>	+	<SX load='5kep' size='340' side='right' viewer='molstar' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv16 Hpv16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KEP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv16 Hpv16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KEP FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5kep" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5kep" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Major capsid protein L1\|Major capsid protein L1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Hpv16]]		[[Category: Hpv16]]
		+	[[Category: Large Structures]]
	[[Category: Ashley, R E]]		[[Category: Ashley, R E]]
	[[Category: Brendle, S A]]		[[Category: Brendle, S A]]

OCA at 07:38, 6 December 2017

OCA — Wed, 06 Dec 2017 07:38:34 GMT

←Older revision		Revision as of 07:38, 6 December 2017
Line 3:		Line 3:
	<StructureSection load='5kep' size='340' side='right' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>		<StructureSection load='5kep' size='340' side='right' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KEP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv16 Hpv16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KEP FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5keq\|5keq]], [[5key\|5key]], [[5kgb\|5kgb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5keq\|5keq]], [[5key\|5key]], [[5kgb\|5kgb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333760 HPV16])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kep OCA], [http://pdbe.org/5kep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kep RCSB], [http://www.ebi.ac.uk/pdbsum/5kep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kep ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kep OCA], [http://pdbe.org/5kep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kep RCSB], [http://www.ebi.ac.uk/pdbsum/5kep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kep ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hpv16]]
	[[Category: Ashley, R E]]		[[Category: Ashley, R E]]
	[[Category: Brendle, S A]]		[[Category: Brendle, S A]]
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	[[Category: Makhov, A M]]		[[Category: Makhov, A M]]
	[[Category: Asymmetric unit]]		[[Category: Asymmetric unit]]
-	[[Category: Hpv16]]
	[[Category: L1 protein]]		[[Category: L1 protein]]
	[[Category: Virus like particle]]		[[Category: Virus like particle]]

OCA at 23:35, 25 January 2017

OCA — Wed, 25 Jan 2017 23:35:09 GMT

←Older revision		Revision as of 23:35, 25 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kep is ~~ON HOLD~~	+	==High resolution cryo-EM maps of Human Papillomavirus 16 reveal L2 location and heparin-induced conformational changes==
		+	<StructureSection load='5kep' size='340' side='right' caption='[[5kep]], [[Resolution\|resolution]] 4.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5kep]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KEP FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5keq\|5keq]], [[5key\|5key]], [[5kgb\|5kgb]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kep OCA], [http://pdbe.org/5kep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kep RCSB], [http://www.ebi.ac.uk/pdbsum/5kep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kep ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. The current commercial vaccines are genotype specific and provide little therapeutic benefit to patients with existing HPV infections. Host entry mechanisms represent an excellent target for alternative therapeutics, but HPV receptor use, the details of cell attachment, and host entry are inadequately understood. Here we present near-atomic resolution structures of the HPV16 capsid and HPV16 in complex with heparin, both determined from cryoelectron micrographs collected with direct electron detection technology. The structures clarify details of capsid architecture for the first time, including variation in L1 major capsid protein conformation and putative location of L2 minor protein. Heparin binds specifically around the capsid icosahedral vertices and may recapitulate the earliest stage of infection, providing a framework for continuing biochemical, genetic, and biophysical studies.

-	~~Authors~~:	+	Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site.,Guan J, Bywaters SM, Brendle SA, Ashley RE, Makhov AM, Conway JF, Christensen ND, Hafenstein S Structure. 2016 Dec 31. pii: S0969-2126(16)30391-4. doi:, 10.1016/j.str.2016.12.001. PMID:28065506<ref>PMID:28065506</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5kep" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ashley, R E]]
		+	[[Category: Brendle, S A]]
		+	[[Category: Bywaters, S M]]
		+	[[Category: Christensen, N D]]
		+	[[Category: Conway, J F]]
		+	[[Category: Guan, J]]
		+	[[Category: Hafenstein, S]]
		+	[[Category: Makhov, A M]]
		+	[[Category: Asymmetric unit]]
		+	[[Category: Hpv16]]
		+	[[Category: L1 protein]]
		+	[[Category: Virus like particle]]

OCA: Protected "5kep" [edit=sysop:move=sysop]

OCA — Thu, 23 Jun 2016 21:31:02 GMT

Protected "5kep" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:31, 23 June 2016

OCA: New page: '''Unreleased structure''' The entry 5kep is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 23 Jun 2016 21:31:00 GMT

New page: '''Unreleased structure''' The entry 5kep is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5kep is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]